EHMT2 and NAA10

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		EHMT2	NAA10
Gene Name		euchromatic histone-lysine N-methyltransferase 2	N(alpha)-acetyltransferase 10, NatA catalytic subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton	Intracellular Nucleus Nucleolus Cytoplasm Membrane Cytosolic Ribosome NatA Complex
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding	Peptide Alpha-N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity Acetyltransferase Activity Ribosome Binding Peptide-serine-N-acetyltransferase Activity Peptide-glutamate-N-acetyltransferase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Replication DNA Methylation Chromatin Organization Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Histone H3-K9 Methylation Histone H3-K27 Methylation	DNA Packaging N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation N-terminal Peptidyl-serine Acetylation N-terminal Peptidyl-glutamic Acid Acetylation
Pathways		Chromatin modifying enzymes Chromatin organization RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation PKMTs methylate histone lysines RNA Polymerase I Promoter Clearance Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS		Chronic hepatitis B infection ( 23760081) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239)
Protein-Protein Interactions		42 interactors: C10orf12 CACNA1A CBX1 CCDC33 CHCHD2 CUX1 DNMT3A E4F1 ESR1 FAM161A H3F3B HGS HIST1H1A HIST1H1B HIST1H3A HIST2H3A HIST2H3C HIST3H3 ITGB5 KLF12 KLF3 KLF6 LIMS1 LMO2 LNX1 MX2 NAA10 NAPRT PLOD3 PRRC2B PSMA1 RD3 RELB RERE RUVBL2 THAP7 TP53 WIZ XAGE2 ZBTB38 ZNF512B ZNF785	24 interactors: BCOR CALCOCO2 CDC25A CEP44 EHMT2 FIP1L1 HIF1A KIFAP3 KRTAP10-3 KRTAP10-5 KRTAP10-7 MEOX2 NAA15 NAA16 NAA50 NAT1 NAT2 PDE4DIP PSME2 RAB3IP RBCK1 RPL26 SSX2IP ZBTB14
Entrez ID		10919	8260
HPRD ID		06854	02056
Ensembl ID		ENSG00000204371
Uniprot IDs		A2ABF8 A2ABF9 Q96KQ7	B4DKJ7 B7Z9N2 P41227
PDB IDs		2O8J 3DM1 3K5K 3RJW
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Silencing Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Silencing At RDNA DNA Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Conformation Change Regulation Of Metabolic Process Chromosome Organization DNA Modification DNA Packaging Transcription, DNA-templated Gene Silencing RNA Biosynthetic Process Chromatin Organization Chromatin Assembly Chromatin Assembly Or Disassembly Positive Regulation Of Gene Expression Cellular Component Assembly Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Establishment Of Protein Localization To Chromatin RNA Metabolic Process Nucleosome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleosome Organization Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Protein-DNA Complex Assembly Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated	N-terminal Protein Amino Acid Acetylation N-terminal Protein Amino Acid Modification Protein Acetylation Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Protein Stabilization Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Regulation Of Cell Death Microtubule-based Transport Regulation Of Protein Stability Cytoskeleton-dependent Intracellular Transport Cellular Protein Modification Process Neutral Amino Acid Transport Negative Regulation Of Histone H3-K36 Methylation Mitotic Sister Chromatid Cohesion, Centromeric Neural Fold Elevation Formation Positive Regulation Of Calcium-dependent Cell-cell Adhesion Viral Process Cellular Protein Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Bone Mineralization Negative Regulation Of Tooth Mineralization Elastin Metabolic Process Protein Metabolic Process Negative Regulation Of Ossification Microtubule-based Movement Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Protein Linear Polyubiquitination Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development DNA Methylation On Cytosine Within A CG Sequence Intestinal Epithelial Cell Maturation Cellular Nitrogen Compound Metabolic Process Palate Development Positive Regulation Of Transcription, DNA-templated Histone Modification Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Specification Of Axis Polarity Norepinephrine Transport Amino Acid Transmembrane Transport Gene Expression Regulation Of Transcription, DNA-templated
Tagcloud ?		availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility	00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 predisposition predominance prototype prototypic prps2 replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Difference) ?		availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility	00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 predisposition predominance prototype prototypic prps2 replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Intersection) ?