EHMT2 and CUX1

Number of citations of the paper that reports this interaction (PMID 15269344)
53

Data Source:
HPRD (in vitro)

		EHMT2	CUX1
Gene Name		euchromatic histone-lysine N-methyltransferase 2	cut-like homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton	Nucleus Cytosol Integral Component Of Golgi Membrane
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Replication DNA Methylation Chromatin Organization Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Histone H3-K9 Methylation Histone H3-K27 Methylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intra-Golgi Vesicle-mediated Transport Multicellular Organismal Development Lung Development Auditory Receptor Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Dendrite Morphogenesis
Pathways		Chromatin modifying enzymes Chromatin organization RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation PKMTs methylate histone lysines RNA Polymerase I Promoter Clearance Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)	Signaling by FGFR in disease Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS		Chronic hepatitis B infection ( 23760081) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239)	Response to antidepressants ( 22584459)
Protein-Protein Interactions		42 interactors: C10orf12 CACNA1A CBX1 CCDC33 CHCHD2 CUX1 DNMT3A E4F1 ESR1 FAM161A H3F3B HGS HIST1H1A HIST1H1B HIST1H3A HIST2H3A HIST2H3C HIST3H3 ITGB5 KLF12 KLF3 KLF6 LIMS1 LMO2 LNX1 MX2 NAA10 NAPRT PLOD3 PRRC2B PSMA1 RD3 RELB RERE RUVBL2 THAP7 TP53 WIZ XAGE2 ZBTB38 ZNF512B ZNF785	20 interactors: BIN1 CA12 CCNA1 CDC25A CDK1 CDK7 CREBBP CTSL CYTH2 EHMT2 ELAC2 GOLGA5 HMGB1 KAT2B MAX RB1 RECQL5 SATB1 SDC3 TLE4
Entrez ID		10919	1523
HPRD ID		06854	00295
Ensembl ID		ENSG00000204371	ENSG00000257923
Uniprot IDs		A2ABF8 A2ABF9 Q96KQ7	P39880 Q13948 Q3LIA3
PDB IDs		2O8J 3DM1 3K5K 3RJW
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Silencing Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Silencing At RDNA DNA Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Conformation Change Regulation Of Metabolic Process Chromosome Organization DNA Modification DNA Packaging Transcription, DNA-templated Gene Silencing RNA Biosynthetic Process Chromatin Organization Chromatin Assembly Chromatin Assembly Or Disassembly Positive Regulation Of Gene Expression Cellular Component Assembly Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Establishment Of Protein Localization To Chromatin RNA Metabolic Process Nucleosome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleosome Organization Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Protein-DNA Complex Assembly Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization G1/S Transition Of Mitotic Cell Cycle Chromatin Modification Negative Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cell Division Cell Cycle Process Chromatin Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Viral Process Mitotic Nuclear Division Regulation Of Cell Cycle Cell Cycle Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Histone Modification Mitotic Cell Cycle Process Chromatin Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Protein Kinase Activity Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Regulation Of Nucleic Acid-templated Transcription Protein Localization To Chromosome, Centromeric Region Regulation Of RNA Biosynthetic Process N-terminal Protein Amino Acid Acetylation Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Catalytic Activity Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Apoptotic Process Regulation Of Gene Expression Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Cell Death
Tagcloud ?		availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility	accumulated activators ancillary base burden cut ectopic excision framework haploinsufficiency homeobox implicated isoform isoforms mechanistic opposite paradoxically progression promotes protection reconcile repressors supports suppression transgenic tumorigenesis tumour whereby yet
Tagcloud (Difference) ?		availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility	accumulated activators ancillary base burden cut ectopic excision framework haploinsufficiency homeobox implicated isoform isoforms mechanistic opposite paradoxically progression promotes protection reconcile repressors supports suppression transgenic tumorigenesis tumour whereby yet
Tagcloud (Intersection) ?