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RIC8A and GNAS
Number of citations of the paper that reports this interaction (PMID
12652642
)
15
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
RIC8A
GNAS
Gene Name
RIC8 guanine nucleotide exchange factor A
GNAS complex locus
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Ruffle
Extracellular Region
Nucleus
Cytoplasm
Cytosol
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
Transport Vesicle
Dendrite
Intrinsic Component Of Membrane
Trans-Golgi Network Membrane
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
G-protein Alpha-subunit Binding
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Molecular_function
GTPase Activity
Adenylate Cyclase Activity
Signal Transducer Activity
Insulin-like Growth Factor Receptor Binding
Protein Binding
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
Beta-2 Adrenergic Receptor Binding
D1 Dopamine Receptor Binding
Mu-type Opioid Receptor Binding
Ionotropic Glutamate Receptor Binding
Metal Ion Binding
Corticotropin-releasing Hormone Receptor 1 Binding
Biological Process
In Utero Embryonic Development
Vasculature Development
G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Visual Learning
Cell Migration Involved In Gastrulation
Positive Regulation Of GTPase Activity
Cell-cell Adhesion Involved In Gastrulation
Basement Membrane Organization
Tissue Homeostasis
Endochondral Ossification
Renal Water Homeostasis
Energy Reserve Metabolic Process
CAMP Biosynthetic Process
DNA Methylation
Water Transport
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Female Pregnancy
Blood Coagulation
Sensory Perception Of Chemical Stimulus
Sensory Perception Of Smell
Protein Secretion
Positive Regulation Of CAMP Biosynthetic Process
Positive Regulation Of Ras GTPase Activity
Embryonic Hindlimb Morphogenesis
Multicellular Organism Growth
Negative Regulation Of Multicellular Organism Growth
Post-embryonic Body Morphogenesis
Response To Drug
Positive Regulation Of CAMP-mediated Signaling
Small Molecule Metabolic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Osteoclast Differentiation
Intracellular Transport
Developmental Growth
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Insulin Secretion
Cognition
Cartilage Development
Transmembrane Transport
Bone Development
Hair Follicle Placode Formation
Platelet Aggregation
Response To Parathyroid Hormone
Cellular Response To Glucagon Stimulus
Cellular Response To Prostaglandin E Stimulus
Genetic Imprinting
Cellular Response To Catecholamine Stimulus
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Integration of energy metabolism
Hedgehog 'off' state
G alpha (s) signalling events
Glucagon-type ligand receptors
Metabolic disorders of biological oxidation enzymes
G alpha (z) signalling events
G alpha (i) signalling events
Class B/2 (Secretin family receptors)
Glucagon signaling in metabolic regulation
Prostacyclin signalling through prostacyclin receptor
PKA activation in glucagon signalling
Vasopressin regulates renal water homeostasis via Aquaporins
Regulation of insulin secretion
GPCR ligand binding
Aquaporin-mediated transport
GPCR downstream signaling
Platelet homeostasis
Signaling by Hedgehog
Drugs
Diseases
GWAS
Uterine fibroids (
21460842
)
Blood pressure (
21909110
)
Diastolic blood pressure (
21909115
)
DNA methylation (variation) (
23725790
)
Hypertension (
21909115
)
Renal function-related traits (BUN) (
22797727
)
Response to diuretic therapy in hypertension (
23753411
)
Systolic blood pressure (
21909115
)
Protein-Protein Interactions
20 interactors:
EFEMP1
GNA13
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
GNAS
MAPK8IP3
NECAB2
NUTM1
RABAC1
SDCBP
TERF1
TUBB2A
UBQLN1
UBQLN4
XPO1
ZDHHC17
ZNF585B
31 interactors:
ADCY2
ADCY5
ADCY6
ADORA1
ADRB2
ADRB3
AVPR2
AXIN1
CALM1
CAV3
CRHR1
GCGR
GNB1
GNGT1
HTR6
LHB
LHCGR
NUCB1
NUCB2
OPTN
PANX1
PTGDR
PTGIR
RGS2
RIC8A
RIC8B
SNX13
TBXA2R
TSHR
TTC1
VIPR1
Entrez ID
60626
2778
HPRD ID
12373
00761
Ensembl ID
ENSG00000177963
ENSG00000087460
Uniprot IDs
Q9NPQ8
O95467
P63092
P84996
Q5JWF2
PDB IDs
Enriched GO Terms of Interacting Partners
?
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Platelet Activation
Blood Coagulation
Hemostasis
Dopamine Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Response To Wounding
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Regulation Of Adenylate Cyclase Activity
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Cyclase Activity
Regulation Of Metabolic Process
Signal Transduction
Regulation Of CAMP Biosynthetic Process
Cellular Response To Stimulus
Regulation Of CAMP Metabolic Process
Signaling
Cell Communication
Response To Stimulus
Regulation Of Catalytic Activity
Negative Regulation Of Adenylate Cyclase Activity
Negative Regulation Of Lyase Activity
Post-embryonic Development
Regulation Of Cellular Process
Negative Regulation Of CAMP Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Cell Division
Response To Stress
Negative Regulation Of CAMP Metabolic Process
Negative Regulation Of Nucleotide Metabolic Process
Response To Drug
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Catalytic Activity
Vesicle Fusion
Synaptic Transmission
Post-embryonic Body Morphogenesis
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Phospholipase Activity
Organelle Fusion
Positive Regulation Of Signal Transduction
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phospholipase Activity
Positive Regulation Of Lipase Activity
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of CAMP Biosynthetic Process
Cell-cell Signaling
Activation Of Adenylate Cyclase Activity
Regulation Of Catalytic Activity
Positive Regulation Of CAMP Metabolic Process
Positive Regulation Of Adenylate Cyclase Activity
Signal Transduction
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Regulation Of CAMP Biosynthetic Process
Positive Regulation Of Lyase Activity
Regulation Of CAMP Metabolic Process
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Signaling
Cell Communication
Regulation Of Adenylate Cyclase Activity
Regulation Of Cyclase Activity
Energy Reserve Metabolic Process
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Metabolic Process
Cellular Response To Glucagon Stimulus
Synaptic Transmission
Cellular Response To Stimulus
Positive Regulation Of Hydrolase Activity
Response To Stress
Response To Glucagon
Response To Hormone
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Response To Stimulus
Regulation Of Body Fluid Levels
Cellular Response To Hormone Stimulus
Homeostatic Process
Regulation Of Muscle Contraction
Response To Organic Substance
Renal Water Homeostasis
Energy Derivation By Oxidation Of Organic Compounds
Regulation Of Cellular Process
Regulation Of Phospholipase Activity
Regulation Of Blood Pressure
Blood Circulation
Regulation Of Signaling
Vasodilation
Negative Regulation Of Ion Transport
Renal System Process
Regulation Of Protein Kinase Activity
Tagcloud
?
accompanying
addressed
adenylyl
allergic
bias
camp
cd11c
cyclases
dc
dendritic
encodes
focusing
galphai
galphas
gap
gnasdeltacd11c
gtp
heterotrimeric
immunopathologies
imply
inductive
pka
polarization
prominent
provoke
th
th2
turn
yields
Tagcloud (Difference)
?
accompanying
addressed
adenylyl
allergic
bias
camp
cd11c
cyclases
dc
dendritic
encodes
focusing
galphai
galphas
gap
gnasdeltacd11c
gtp
heterotrimeric
immunopathologies
imply
inductive
pka
polarization
prominent
provoke
th
th2
turn
yields
Tagcloud (Intersection)
?