RIC8A

Description		RIC8 guanine nucleotide exchange factor A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Membrane
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Folding Chaperone
	Biological Process	In Utero Embryonic Development Vasculature Development Protein Folding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Visual Learning Response To Light Stimulus Cell Migration Involved In Gastrulation Cell-cell Adhesion Involved In Gastrulation Basement Membrane Organization
Pathways
Drugs
Diseases
GWAS		Cataracts ( 34127677) Cataracts (operation) ( 31816047) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Mean corpuscular hemoglobin concentration ( 29403010) Meningioma ( 29762745) Platelet count ( 24026423) Uterine fibroids ( 21460842 31488892 31649266) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		27 interacting genes: ATP1A4 EFEMP1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS MAPK8IP3 MID1 NECAB2 NUTM1 OGT PACSIN2 PDE4B RABAC1 SDCBP SH3GLB1 SLC2A13 TERF1 TUBB2A UBQLN1 UBQLN4 XPO1 ZDHHC17 ZNF585B
Entrez ID		60626
HPRD ID		12373
Ensembl ID		ENSG00000177963
Uniprot IDs		Q9NPQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase Regulator Activity GTPase Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTP Binding G Protein Activity G Protein-coupled Receptor Binding Mu-type Opioid Receptor Binding Cytoplasm Negative Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cell Body Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cellular Component Organization Cytoplasmic Vesicle Regulation Of Cell Communication Centriolar Satellite Regulation Of Protein Localization Regulation Of Signaling Plasma Membrane Regulation Of Transport Negative Regulation Of Cellular Component Organization Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Golgi Apparatus Regulation Of Establishment Of Protein Localization G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endocytosis Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Midbody Identical Protein Binding Regulation Of Macroautophagy Regulation Of Relaxation Of Muscle Negative Regulation Of Receptor Internalization Regulation Of Proteasomal Protein Catabolic Process Extracellular Vesicle Cellular Response To Acidic PH Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Cell Projection G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
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