RIC8A and GNAQ

Number of citations of the paper that reports this interaction (PMID 12509430)
65

Data Source:
HPRD (two hybrid, in vitro)

		RIC8A	GNAQ
Gene Name		RIC8 guanine nucleotide exchange factor A	guanine nucleotide binding protein (G protein), q polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Vasculature Development G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Visual Learning Cell Migration Involved In Gastrulation Positive Regulation Of GTPase Activity Cell-cell Adhesion Involved In Gastrulation Basement Membrane Organization	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways			G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs
Diseases
GWAS		Uterine fibroids ( 21460842)
Protein-Protein Interactions		20 interactors: EFEMP1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS MAPK8IP3 NECAB2 NUTM1 RABAC1 SDCBP TERF1 TUBB2A UBQLN1 UBQLN4 XPO1 ZDHHC17 ZNF585B	48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		60626	2776
HPRD ID		12373	02998
Ensembl ID		ENSG00000177963
Uniprot IDs		Q9NPQ8	P50148
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Blood Coagulation Hemostasis Dopamine Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of Metabolic Process Signal Transduction Regulation Of CAMP Biosynthetic Process Cellular Response To Stimulus Regulation Of CAMP Metabolic Process Signaling Cell Communication Response To Stimulus Regulation Of Catalytic Activity Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Post-embryonic Development Regulation Of Cellular Process Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Cell Division Response To Stress Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Response To Drug Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Catalytic Activity Vesicle Fusion Synaptic Transmission Post-embryonic Body Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of Phospholipase Activity Organelle Fusion Positive Regulation Of Signal Transduction Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Cellular Protein Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling
Tagcloud ?			adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Difference) ?			adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Intersection) ?