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RIC8A and TUBB2A
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
RIC8A
TUBB2A
Gene Name
RIC8 guanine nucleotide exchange factor A
tubulin, beta 2A class IIa
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Nucleus
Cytoplasm
Microtubule
Vesicle
Extracellular Vesicular Exosome
Molecular Function
G-protein Alpha-subunit Binding
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
GTPase Activity
Structural Constituent Of Cytoskeleton
GTP Binding
Biological Process
In Utero Embryonic Development
Vasculature Development
G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Visual Learning
Cell Migration Involved In Gastrulation
Positive Regulation Of GTPase Activity
Cell-cell Adhesion Involved In Gastrulation
Basement Membrane Organization
Protein Folding
Microtubule-based Process
Cellular Protein Metabolic Process
'de Novo' Posttranslational Protein Folding
Protein Polymerization
Transmembrane Transport
Pathways
Transport of connexons to the plasma membrane
Mitotic Prometaphase
Organelle biogenesis and maintenance
Axon guidance
Hedgehog 'off' state
Separation of Sister Chromatids
Translocation of GLUT4 to the plasma membrane
G2/M Transition
L1CAM interactions
Mitotic Anaphase
Recycling pathway of L1
Recruitment of NuMA to mitotic centrosomes
Formation of tubulin folding intermediates by CCT/TriC
Intraflagellar transport
M Phase
Prefoldin mediated transfer of substrate to CCT/TriC
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Post-chaperonin tubulin folding pathway
Gap junction trafficking and regulation
MHC class II antigen presentation
Recruitment of mitotic centrosome proteins and complexes
Orphan transporters
Protein folding
Gap junction assembly
Gap junction trafficking
Kinesins
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Assembly of the primary cilium
Factors involved in megakaryocyte development and platelet production
Cell Cycle, Mitotic
Resolution of Sister Chromatid Cohesion
Chaperonin-mediated protein folding
Signaling by Hedgehog
Centrosome maturation
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Uterine fibroids (
21460842
)
Protein-Protein Interactions
20 interactors:
EFEMP1
GNA13
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
GNAS
MAPK8IP3
NECAB2
NUTM1
RABAC1
SDCBP
TERF1
TUBB2A
UBQLN1
UBQLN4
XPO1
ZDHHC17
ZNF585B
24 interactors:
ACD
ARL15
CHGB
DISC1
HDAC6
HGS
HMMR
LAMA4
PAFAH1B3
POT1
PSMD11
PTPRS
RABAC1
RIC8A
RPA2
RPLP1
SAT1
SDC3
SERPINB9
TERF1
TK1
TNIK
TPT1
UPF2
Entrez ID
60626
7280
HPRD ID
12373
Ensembl ID
ENSG00000177963
ENSG00000137267
Uniprot IDs
Q9NPQ8
Q13885
PDB IDs
Enriched GO Terms of Interacting Partners
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Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Platelet Activation
Blood Coagulation
Hemostasis
Dopamine Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Response To Wounding
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Regulation Of Adenylate Cyclase Activity
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Cyclase Activity
Regulation Of Metabolic Process
Signal Transduction
Regulation Of CAMP Biosynthetic Process
Cellular Response To Stimulus
Regulation Of CAMP Metabolic Process
Signaling
Cell Communication
Response To Stimulus
Regulation Of Catalytic Activity
Negative Regulation Of Adenylate Cyclase Activity
Negative Regulation Of Lyase Activity
Post-embryonic Development
Regulation Of Cellular Process
Negative Regulation Of CAMP Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Cell Division
Response To Stress
Negative Regulation Of CAMP Metabolic Process
Negative Regulation Of Nucleotide Metabolic Process
Response To Drug
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Catalytic Activity
Vesicle Fusion
Synaptic Transmission
Post-embryonic Body Morphogenesis
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Phospholipase Activity
Organelle Fusion
Positive Regulation Of Signal Transduction
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phospholipase Activity
Positive Regulation Of Lipase Activity
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Telomerase Activity
Telomere Maintenance
Regulation Of Telomere Maintenance
Telomere Maintenance Via Telomere Lengthening
Telomere Assembly
Regulation Of DNA Biosynthetic Process
Telomere Capping
Negative Regulation Of DNA Replication
Catabolic Process
Positive Regulation Of Telomerase Activity
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomerase Activity
Negative Regulation Of Chromosome Organization
Negative Regulation Of DNA Metabolic Process
Cellular Protein Localization
Positive Regulation Of DNA Biosynthetic Process
Cellular Component Assembly
RNA-dependent DNA Replication
Regulation Of DNA Replication
Negative Regulation Of DNA Biosynthetic Process
Response To Stimulus
Developmental Process
Regulation Of Proteolysis
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Protein Catabolic Process
Mitotic Cell Cycle Checkpoint
Glycosaminoglycan Metabolic Process
Negative Regulation Of Catalytic Activity
Regulation Of Catalytic Activity
Regulation Of Chromosome Organization
Cellular Macromolecule Catabolic Process
Cellular Localization
Pathogenesis
Cell-cell Adhesion Involved In Gastrulation
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Positive Regulation Of Single-stranded Telomeric DNA Binding
Positive Regulation Of DNA Strand Elongation
Fetal Process Involved In Parturition
Hsp90 Deacetylation
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Homeostatic Process
Protein Localization
Intracellular Protein Transport
Regulation Of Cell Cycle Phase Transition
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