RIC8A and MAPK8IP3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RIC8A	MAPK8IP3
Gene Name		RIC8 guanine nucleotide exchange factor A	mitogen-activated protein kinase 8 interacting protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane	Golgi Membrane Cytoplasm Smooth Endoplasmic Reticulum Dendrite Axolemma
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	MAP-kinase Scaffold Activity JUN Kinase Binding Kinesin Binding Receptor Signaling Complex Scaffold Activity Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	In Utero Embryonic Development Vasculature Development G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Visual Learning Cell Migration Involved In Gastrulation Positive Regulation Of GTPase Activity Cell-cell Adhesion Involved In Gastrulation Basement Membrane Organization	In Utero Embryonic Development Activation Of JUN Kinase Activity Axon Guidance Respiratory Gaseous Exchange Protein Localization Post-embryonic Development Regulation Of Gene Expression Vesicle-mediated Transport Forebrain Development Positive Regulation Of Neuron Differentiation Regulation Of JNK Cascade Lung Alveolus Development Lung Morphogenesis
Pathways
Drugs
Diseases
GWAS		Uterine fibroids ( 21460842)
Protein-Protein Interactions		20 interactors: EFEMP1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS MAPK8IP3 NECAB2 NUTM1 RABAC1 SDCBP TERF1 TUBB2A UBQLN1 UBQLN4 XPO1 ZDHHC17 ZNF585B	21 interactors: ARL4D CASP3 KLC1 KLC2 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 PTK2 RAF1 RIC8A SRC TLR2 TLR4 TLR9
Entrez ID		60626	23162
HPRD ID		12373	12014
Ensembl ID		ENSG00000177963	ENSG00000138834
Uniprot IDs		Q9NPQ8	E9PFH7 Q9UPT6
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Blood Coagulation Hemostasis Dopamine Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of Metabolic Process Signal Transduction Regulation Of CAMP Biosynthetic Process Cellular Response To Stimulus Regulation Of CAMP Metabolic Process Signaling Cell Communication Response To Stimulus Regulation Of Catalytic Activity Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Post-embryonic Development Regulation Of Cellular Process Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Cell Division Response To Stress Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Response To Drug Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Catalytic Activity Vesicle Fusion Synaptic Transmission Post-embryonic Body Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of Phospholipase Activity Organelle Fusion Positive Regulation Of Signal Transduction Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Cellular Protein Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade JNK Cascade Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Kinase Activity Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAP Kinase Activity Response To Stress Positive Regulation Of Innate Immune Response Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Toll-like Receptor 9 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
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