RIC8A and ATP1A4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RIC8A	ATP1A4
Description		RIC8 guanine nucleotide exchange factor A	ATPase Na+/K+ transporting subunit alpha 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Membrane	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Cell Projection Membrane Raft Sperm Midpiece Photoreceptor Cell Cilium Rod Photoreceptor Outer Segment
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Folding Chaperone	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Kinase Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Vasculature Development Protein Folding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Visual Learning Response To Light Stimulus Cell Migration Involved In Gastrulation Cell-cell Adhesion Involved In Gastrulation Basement Membrane Organization	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Cell Surface Receptor Signaling Pathway Spermatogenesis Fertilization Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Flagellated Sperm Motility Regulation Of Cellular PH Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Transport Across Blood-brain Barrier Proton Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways			Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Bisacodyl Tegoprazan
Diseases
GWAS		Cataracts ( 34127677) Cataracts (operation) ( 31816047) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Mean corpuscular hemoglobin concentration ( 29403010) Meningioma ( 29762745) Platelet count ( 24026423) Uterine fibroids ( 21460842 31488892 31649266) Uterine fibroids (MTAG) ( 31488892)	Composite immunoglobulin trait (IgA/IgG) ( 28628107) Gout ( 22179738)
Interacting Genes		27 interacting genes: ATP1A4 EFEMP1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS MAPK8IP3 MID1 NECAB2 NUTM1 OGT PACSIN2 PDE4B RABAC1 SDCBP SH3GLB1 SLC2A13 TERF1 TUBB2A UBQLN1 UBQLN4 XPO1 ZDHHC17 ZNF585B	3 interacting genes: CTAG1A CTAG1B RIC8A
Entrez ID		60626	480
HPRD ID		12373	09541
Ensembl ID		ENSG00000177963	ENSG00000132681
Uniprot IDs		Q9NPQ8	Q13733
PDB IDs			8ZYJ
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase Regulator Activity GTPase Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTP Binding G Protein Activity G Protein-coupled Receptor Binding Mu-type Opioid Receptor Binding Cytoplasm Negative Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cell Body Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cellular Component Organization Cytoplasmic Vesicle Regulation Of Cell Communication Centriolar Satellite Regulation Of Protein Localization Regulation Of Signaling Plasma Membrane Regulation Of Transport Negative Regulation Of Cellular Component Organization Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Golgi Apparatus Regulation Of Establishment Of Protein Localization G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endocytosis Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Midbody Identical Protein Binding Regulation Of Macroautophagy Regulation Of Relaxation Of Muscle Negative Regulation Of Receptor Internalization Regulation Of Proteasomal Protein Catabolic Process Extracellular Vesicle Cellular Response To Acidic PH Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Cell Projection G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction	TRNA Threonylcarbamoyladenosine Metabolic Process Cell-cell Adhesion Involved In Gastrulation TRNA Metabolic Process Cell Migration Involved In Gastrulation
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