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RIC8A and NECAB2
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
RIC8A
NECAB2
Description
RIC8 guanine nucleotide exchange factor A
N-terminal EF-hand calcium binding protein 2
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Cell Cortex
Membrane
Cytoplasm
Plasma Membrane
Membrane
Axon
Dendrite
Cell Projection
Presynapse
Postsynapse
Molecular Function
G-protein Alpha-subunit Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Folding Chaperone
Calcium Ion Binding
Protein Binding
A2A Adenosine Receptor Binding
Type 5 Metabotropic Glutamate Receptor Binding
Identical Protein Binding
Metal Ion Binding
Biological Process
In Utero Embryonic Development
Vasculature Development
Protein Folding
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Gastrulation
Visual Learning
Response To Light Stimulus
Cell Migration Involved In Gastrulation
Cell-cell Adhesion Involved In Gastrulation
Basement Membrane Organization
Regulation Of Amyloid Precursor Protein Biosynthetic Process
Positive Regulation Of Adenosine Receptor Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Glutamate Receptor Signaling Pathway
Negative Regulation Of G Protein-coupled Receptor Internalization
Positive Regulation Of Protein Localization To Membrane
Pathways
Drugs
Diseases
GWAS
Cataracts (
34127677
)
Cataracts (operation) (
31816047
)
Gynecologic disease (
31488892
)
Gynecologic disease (multivariate analysis) (
31488892
)
Mean corpuscular hemoglobin concentration (
29403010
)
Meningioma (
29762745
)
Platelet count (
24026423
)
Uterine fibroids (
21460842
31488892
31649266
)
Uterine fibroids (MTAG) (
31488892
)
Body mass index (change over time) (
25378290
)
Corneal astigmatism (
29422769
)
Response to platinum-based neoadjuvant chemotherapy in cervical cancer (
28120872
)
Rheumatoid arthritis (
30891314
)
Interacting Genes
27 interacting genes:
ATP1A4
EFEMP1
GNA13
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
GNAS
MAPK8IP3
MID1
NECAB2
NUTM1
OGT
PACSIN2
PDE4B
RABAC1
SDCBP
SH3GLB1
SLC2A13
TERF1
TUBB2A
UBQLN1
UBQLN4
XPO1
ZDHHC17
ZNF585B
91 interacting genes:
ADORA2A
AIMP2
AIRIM
BEX2
BEX3
BYSL
C19orf25
C1orf216
CAGE1
CAPN3
CARD9
CCDC121
CCDC146
CCDC33
CCNK
CDC37
CENPO
CPEB2
DAXX
DFFA
DGCR6
DGCR6L
DRC12
DTNBP1
DYNC1I2
EAF2
EHHADH
EIF4E2
EMILIN1
FAM161A
FAM161B
FANCG
FMR1
FXR1
FXR2
GCC1
GOLGA2
GTPBP10
HAUS1
INPP1
INTS10
ISCU
KANK2
KANSL1
KDM1A
KIFC3
KLC3
KLC4
KPNA2
LENG1
LNX1
MED14
MRPS27
MSGN1
MTCL2
MTMR9
MYO15B
MYPOP
NEK6
NIP7
NOC4L
NTAQ1
ODAD3
ODAD4
OIP5
PATJ
PICK1
POLR2C
PRKAA2
PRPF18
PSMA1
PUS10
RCOR3
RIC8A
RUNX1T1
SDCBP
SH2D4A
SMARCA2
SMARCD1
SNAPIN
SSC5D
TCEA2
TEX11
TRIM59
TRIML2
TSC1
TTR
USHBP1
USP7
VTA1
ZNF655
Entrez ID
60626
54550
HPRD ID
12373
13263
Ensembl ID
ENSG00000177963
ENSG00000103154
Uniprot IDs
Q9NPQ8
Q7Z6G3
PDB IDs
Enriched GO Terms of Interacting Partners
?
Guanyl Nucleotide Binding
G-protein Beta/gamma-subunit Complex Binding
Heterotrimeric G-protein Complex
Adenylate Cyclase Regulator Activity
GTPase Activity
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
GTP Binding
G Protein Activity
G Protein-coupled Receptor Binding
Mu-type Opioid Receptor Binding
Cytoplasm
Negative Regulation Of Transport
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Serotonin Receptor Signaling Pathway
G Protein-coupled Serotonin Receptor Binding
Cell Body
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Response To Prostaglandin E
Corticotropin-releasing Hormone Receptor 1 Binding
Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Cytoplasmic Vesicle
Regulation Of Cell Communication
Centriolar Satellite
Regulation Of Protein Localization
Regulation Of Signaling
Plasma Membrane
Regulation Of Transport
Negative Regulation Of Cellular Component Organization
Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway
Negative Regulation Of Adenylate Cyclase Activity
Golgi Apparatus
Regulation Of Establishment Of Protein Localization
G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Endocytosis
Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Midbody
Identical Protein Binding
Regulation Of Macroautophagy
Regulation Of Relaxation Of Muscle
Negative Regulation Of Receptor Internalization
Regulation Of Proteasomal Protein Catabolic Process
Extracellular Vesicle
Cellular Response To Acidic PH
Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Regulation Of MAPK Cascade
Cell Projection
G Protein-coupled Acetylcholine Receptor Signaling Pathway
G Protein-coupled Dopamine Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Protein Binding
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Translation Regulator Activity
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Presynaptic Modulation Of Chemical Synaptic Transmission
Cytoplasm
Microtubule
Outer Dynein Arm Docking Complex
Cellular Component Assembly
Microtubule-based Movement
Spermatid Development
Regulation Of DNA-templated Transcription Elongation
RNA Strand Annealing Activity
Regulation Of Long-term Neuronal Synaptic Plasticity
Organelle Assembly
Ribosome Biogenesis
Positive Regulation Of Receptor Internalization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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