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NEBL and PRKAB2
Number of citations of the paper that reports this interaction (PMID
24722188
)
1
Data Source:
BioGRID
(two hybrid)
NEBL
PRKAB2
Gene Name
nebulette
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Image
Gene Ontology Annotations
Cellular Component
Stress Fiber
Z Disc
I Band
Extracellular Vesicular Exosome
Nucleoplasm
Cytosol
AMP-activated Protein Kinase Complex
Molecular Function
Protein Binding
Tropomyosin Binding
Cytoskeletal Protein Binding
Structural Constituent Of Muscle
Filamin Binding
Actin Filament Binding
AMP-activated Protein Kinase Activity
Protein Binding
Identical Protein Binding
Biological Process
Cardiac Muscle Thin Filament Assembly
Energy Reserve Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Fatty Acid Biosynthetic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Membrane Organization
Pathways
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Adenosine monophosphate
Diseases
GWAS
Ovarian cancer (
23535730
)
Protein-Protein Interactions
23 interactors:
ACTB
ACTN1
ACTN3
CCDC136
FAM9B
GMCL1
GOLGA2
HOMER3
LZTS2
MAD1L1
MIPOL1
MYPN
NUTM1
PRKAB2
TRAF1
TRAF2
TRIM27
TRIM55
TRIM63
XIRP1
XIRP2
ZDHHC17
ZYX
70 interactors:
ADAMTSL4
BANP
BEND5
BLZF1
CALCOCO2
CASP6
CCDC33
CCDC36
CDX4
CREB3L1
CRX
CSNK2B
DAO
DDIT4L
DICER1
DST
EPM2A
FAM208B
FDX1
FLNC
GATA1
GATAD2B
GET4
GNB2L1
GOLGA2
GRN
IKZF1
IKZF3
KCTD5
KLF15
KRT40
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-4
LZTS2
MAGED1
MDFI
MEOX2
NEBL
PIAS2
PRDM14
PRKAA1
PRKAA2
PRKAG1
PRKAG2
PRKAG3
PSME3
PYGM
RBPMS
REL
RHEBL1
RIMBP3
SPRY2
STX11
STX19
TADA2A
TCF4
TP53BP2
TRAF2
TRIM10
UBXN11
YY1AP1
ZBTB32
Entrez ID
10529
5565
HPRD ID
10403
04117
Ensembl ID
ENSG00000078114
ENSG00000131791
Uniprot IDs
O76041
Q59FZ8
O43741
PDB IDs
4F14
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2Y94
2YA3
4EAI
4EAJ
Enriched GO Terms of Interacting Partners
?
Actin Filament-based Process
Cellular Component Assembly
Actin Cytoskeleton Organization
Cytoskeleton Organization
Cell-cell Junction Organization
Organelle Organization
Adherens Junction Organization
Actomyosin Structure Organization
Focal Adhesion Assembly
Cell-matrix Adhesion
Protein K63-linked Ubiquitination
Protein Trimerization
Cell Junction Assembly
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cell-substrate Adhesion
Adherens Junction Assembly
Signal Transduction
Cell-substrate Junction Assembly
Sarcomere Organization
Regulation Of Metaphase Plate Congression
Actin Filament Bundle Assembly
Signaling
Cell Communication
Actin Filament Organization
Negative Regulation Of Interleukin-2 Secretion
Myofibril Assembly
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cellular Process
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Protein Localization To Tight Junction
Cellular Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Arrest
Transcription, DNA-templated
Regulation Of Gene Expression
RNA Biosynthetic Process
Glycogen Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cell Cycle
Energy Reserve Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Polysaccharide Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Organelle Organization
Gene Expression
Cell Cycle Process
Positive Regulation Of Phosphorylation
RNA Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Signaling
Fatty Acid Biosynthetic Process
Cellular Process
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Binding
Regulation Of Metabolic Process
Regulation Of Carbohydrate Metabolic Process
Regulation Of Phosphorylation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Death
Tagcloud
?
anatomical
assumes
bcc
bccs
binomial
correction
crnkl1
drivers
exome
genesis
hot
intermittent
invex
landscape
lend
melanomas
mutational
passengers
patched
permutation
pick
ptch1
sccs
sequenced
spots
stat5b
stringent
uniform
uniquely
Tagcloud (Difference)
?
anatomical
assumes
bcc
bccs
binomial
correction
crnkl1
drivers
exome
genesis
hot
intermittent
invex
landscape
lend
melanomas
mutational
passengers
patched
permutation
pick
ptch1
sccs
sequenced
spots
stat5b
stringent
uniform
uniquely
Tagcloud (Intersection)
?