NEBL and ACTN3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NEBL	ACTN3
Gene Name		nebulette	actinin, alpha 3 (gene/pseudogene)
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Z Disc I Band Extracellular Vesicular Exosome	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Tropomyosin Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Filamin Binding Actin Filament Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Protein Homodimerization Activity
	Biological Process	Cardiac Muscle Thin Filament Assembly	Muscle Filament Sliding Regulation Of Apoptotic Process Focal Adhesion Assembly
Pathways			Striated Muscle Contraction Nephrin interactions
Drugs
Diseases
GWAS		Ovarian cancer ( 23535730)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		23 interactors: ACTB ACTN1 ACTN3 CCDC136 FAM9B GMCL1 GOLGA2 HOMER3 LZTS2 MAD1L1 MIPOL1 MYPN NUTM1 PRKAB2 TRAF1 TRAF2 TRIM27 TRIM55 TRIM63 XIRP1 XIRP2 ZDHHC17 ZYX	17 interactors: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A BRCA1 C1orf94 KCTD6 MYPN NEBL NRAP PLEKHG2 REL RNF111 SUMO1P1 TRAF1 TRAF2
Entrez ID		10529	89
HPRD ID		10403	02148
Ensembl ID		ENSG00000078114	ENSG00000248746
Uniprot IDs		O76041 Q59FZ8	B4DZQ2 Q08043 Q4VAM3
PDB IDs		4F14	1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Cellular Component Assembly Actin Cytoskeleton Organization Cytoskeleton Organization Cell-cell Junction Organization Organelle Organization Adherens Junction Organization Actomyosin Structure Organization Focal Adhesion Assembly Cell-matrix Adhesion Protein K63-linked Ubiquitination Protein Trimerization Cell Junction Assembly Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell-substrate Adhesion Adherens Junction Assembly Signal Transduction Cell-substrate Junction Assembly Sarcomere Organization Regulation Of Metaphase Plate Congression Actin Filament Bundle Assembly Signaling Cell Communication Actin Filament Organization Negative Regulation Of Interleukin-2 Secretion Myofibril Assembly Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Localization To Tight Junction Cellular Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein Localization To Tight Junction Regulation Of Cell Death Cellular Component Assembly Protein Localization To Cell Junction Platelet Degranulation Regulation Of Apoptotic Process Actin Filament-based Process Actin Crosslink Formation Blood Coagulation Hemostasis Protein Polyubiquitination Focal Adhesion Assembly Platelet Activation Apoptotic Process Cell Junction Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway NIK/NF-kappaB Signaling Cell-cell Junction Organization Programmed Cell Death Protein Autoubiquitination Cell Death Death Regulation Of Body Fluid Levels Tight Junction Assembly Adherens Junction Assembly Actin Cytoskeleton Organization Wound Healing Cytoskeleton Organization Positive Regulation Of Ion Transmembrane Transporter Activity Cell-substrate Junction Assembly Protein Homooligomerization Positive Regulation Of Transporter Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Cardiac Muscle Thin Filament Assembly Actin Filament Bundle Assembly Response To Wounding Regulation Of Signal Transduction Actin Filament Organization Apical Junction Assembly Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Ion Transmembrane Transport Myofibril Assembly Exocytosis Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cytokine Production Adherens Junction Organization Regulation Of Signaling Cellular Response To Tumor Necrosis Factor
Tagcloud ?		anatomical assumes bcc bccs binomial correction crnkl1 drivers exome genesis hot intermittent invex landscape lend melanomas mutational passengers patched permutation pick ptch1 sccs sequenced spots stat5b stringent uniform uniquely	ace bdkrb2 chi2 cl cmj competition counter discriminate distributions elite explosive forward genotypic italian italians jump leg look players sedentary sj soccer squat stepwise strength top traits variance
Tagcloud (Difference) ?		anatomical assumes bcc bccs binomial correction crnkl1 drivers exome genesis hot intermittent invex landscape lend melanomas mutational passengers patched permutation pick ptch1 sccs sequenced spots stat5b stringent uniform uniquely	ace bdkrb2 chi2 cl cmj competition counter discriminate distributions elite explosive forward genotypic italian italians jump leg look players sedentary sj soccer squat stepwise strength top traits variance
Tagcloud (Intersection) ?