NEBL

Description		nebulette
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Z Disc I Band Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Tropomyosin Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Filamin Binding Actin Filament Binding
	Biological Process	Cardiac Muscle Thin Filament Assembly
Pathways
Drugs
Diseases
GWAS		Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Atrial fibrillation ( 28416822) Coronary artery aneurysm in Kawasaki disease ( 27171184) Gastroesophageal reflux disease ( 34187846) Heel bone mineral density ( 30598549) Liver injury in combined anti-retroviral and anti-tuberculosis drug-treated HIV with tuberculosis ( 28388302) Metabolite levels ( 23823483) Ovarian cancer ( 23535730) Photic sneeze reflex ( 27182965) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroid peroxidase levels ( 29678681) Pulse pressure ( 27841878) Refractive error ( 32231278) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Sporadic pituitary adenoma ( 26029870) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Urate levels in lean individuals ( 25811787) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference ( 28552196) Walking pace ( 33128006)
Novel Interacting Genes		2 novel interacting genes: CACNB2 NRP1
Interacting Genes		35 interacting genes: ACAP1 ACTB ACTN1 ACTN3 CCDC125 CCDC136 CEP70 FAM9B GMCL1 GOLGA2 GOLGA6A HOMER3 KIFC3 LZTS2 MAD1L1 MIPOL1 MYPN NUTM1 PIBF1 PIK3R3 PRKAB2 PRRG4 QARS1 SPAG5 TRAF1 TRAF2 TRIM27 TRIM55 TRIM63 VCL XIRP1 XIRP2 ZDHHC17 ZGPAT ZYX
Entrez ID		10529
HPRD ID		10403
Ensembl ID		ENSG00000078114
Uniprot IDs		O76041 Q59FZ8
PDB IDs		4F14
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Focal Adhesion Cytoskeleton Organization Brush Border Actin Cytoskeleton Organization Z Disc Actin Filament-based Process Stress Fiber Adherens Junction Cell Junction Organization Skeletal Muscle Atrophy Actin Filament Binding Skeletal Muscle Adaptation Striated Muscle Atrophy Microtubule Organelle Organization Protein Binding Actin Binding Fascia Adherens Zonula Adherens Platelet Aggregation Muscle Atrophy Cytoskeleton Adherens Junction Organization Anchoring Junction Thioesterase Binding Actin Filament Organization Sarcomere Golgi Cis Cisterna Cytoplasm Actin Cytoskeleton Homotypic Cell-cell Adhesion Protein Kinase Binding Adherens Junction Assembly Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Phosphate Metabolic Process Regulation Of Metaphase Plate Congression Protein K63-linked Ubiquitination Cell-cell Junction Organization Pseudopodium Epithelial Cell-cell Adhesion Actin Filament Negative Regulation Of Glycolytic Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Cell Junction Negative Regulation Of Calcium-mediated Signaling Cell-cell Junction Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Negative Regulation Of Catabolic Process
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