RACK1 and TNFRSF1A

Number of citations of the paper that reports this interaction (PubMedID 12391233)
0

Data Source:
HPRD (in vitro)

		RACK1	TNFRSF1A
Description		receptor for activated C kinase 1	TNF receptor superfamily member 1A
Image
GO Annotations	Cellular Component	Phagocytic Cup Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ribosome Plasma Membrane Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Midbody Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome IRE1-RACK1-PP2A Complex Ribonucleoprotein Complex	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Cell Surface Membrane Receptor Complex Membrane Raft
	Molecular Function	RNA Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Enzyme Activator Activity Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Tyrosine Kinase Inhibitor Activity Cyclin Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Translation Regulator Activity Cadherin Binding BH3 Domain Binding Molecular Adaptor Activity	Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity Tumor Necrosis Factor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Cytoplasmic Translation Translation Regulation Of Translation Apoptotic Process Gastrulation Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Pigmentation Positive Regulation Of GTPase Activity Negative Regulation Of Smoothened Signaling Pathway Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Rescue Of Stalled Ribosome Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Regulation Of Establishment Of Cell Polarity Positive Regulation Of Gastrulation Negative Regulation Of Translational Frameshifting Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Transcription By RNA Polymerase II Prostaglandin Metabolic Process Apoptotic Process Defense Response Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Amide Metabolic Process Non-canonical NF-kappaB Signal Transduction Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Establishment Of Endothelial Barrier Regulation Of Membrane Lipid Metabolic Process
Pathways		Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production Degradation of CDH1	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production TNFs bind their physiological receptors Interleukin-10 signaling TNF signaling
Drugs		Copper	6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One Tasonermin
Diseases			Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 24836286) Crohn's disease ( 26192919) Eosinophil count ( 32888494) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 27386562 24076602 31604244 21833088 19525953) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 21399635 28425483 26394269) Primary biliary cirrhosis ( 22961000) White blood cell count ( 32888494)
Interacting Genes		112 interacting genes: ACTN2 ADH1B ADRB2 AGTRAP AR ARRDC3 ATG14 ATG5 AURKB BCL2L11 BECN1 BIRC6 BRCA1 CCNA1 CDKN1A CHERP CLEC1B CNOT2 CRMP1 CSF2RB DDX19B DNM1 DYNLL1 EED EIF6 ELOB EP300 EPOR ESR1 ESS2 FYN GABRB3 GATA4 GGN GNB1 GOLM1 GPBP1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 KLHL20 LRP12 MAPK6 MCPH1 MKRN2 MTNR1A NFATC1 NR3C1 NSMAF OLA1 PABPC1 PDE4D PIK3R4 PLCG1 PLEC PRKAA1 PRKAB2 PRKAR2A PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SLC9A5 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TENM1 TMEM131 TNFRSF1A TP63 TP73 TSC22D4 TUBB TUBG1 TYK2 USP40 USP54 WDR83 ZSCAN12	67 interacting genes: ADAM17 AKT1 ATF6 BAG4 BCL10 CASP10 CASP7 CCND2 CDK6 CDKN2B CHUK CLIP3 CSNK1A1L DAPK1 DAXX EGFR ERAP1 ERN1 FANCD2 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RACK1 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 STK11 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1
Entrez ID		10399	7132
HPRD ID		01503	01861
Ensembl ID		ENSG00000204628	ENSG00000067182
Uniprot IDs		E9KL35 P63244	J9PH39 P19438
PDB IDs		4AOW 4UG0 4V5Z 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7NWH 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	1EXT 1FT4 1ICH 1NCF 1TNR 7K7A 7KP7 7KP8 7KPB 8P6Q
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Receptor Complex Regulation Of Intracellular Signal Transduction Protein Kinase Binding Plasma Membrane Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Regulation Of Programmed Cell Death Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Developmental Process Regulation Of Apoptotic Process Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Angiogenesis Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Positive Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Intracellular Signaling Cassette Cellular Response To Hormone Stimulus Negative Regulation Of Apoptotic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Reactive Oxygen Species Metabolic Process Transcription Corepressor Binding Phosphorylation Developmental Process Enzyme Binding Positive Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Glycolytic Process Protein Phosphorylation Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Signal Transduction Response To Hormone	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Cytosol Programmed Cell Death Cell Death Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Tumor Necrosis Factor Receptor Binding Regulation Of Defense Response Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Signal Transduction Response To Stress Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Cellular Response To Stress Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Signaling Pathway Kinase Activity Positive Regulation Of Apoptotic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Activation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?