RACK1 and ST7

Number of citations of the paper that reports this interaction (PubMedID 12809483)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		RACK1	ST7
Description		receptor for activated C kinase 1	suppression of tumorigenicity 7
Image			No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ribosome Plasma Membrane Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Midbody Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome IRE1-RACK1-PP2A Complex Ribonucleoprotein Complex	Membrane
	Molecular Function	RNA Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Enzyme Activator Activity Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Tyrosine Kinase Inhibitor Activity Cyclin Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Translation Regulator Activity Cadherin Binding BH3 Domain Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Cytoplasmic Translation Translation Regulation Of Translation Apoptotic Process Gastrulation Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Pigmentation Positive Regulation Of GTPase Activity Negative Regulation Of Smoothened Signaling Pathway Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Rescue Of Stalled Ribosome Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Regulation Of Establishment Of Cell Polarity Positive Regulation Of Gastrulation Negative Regulation Of Translational Frameshifting Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Extracellular Matrix Organization Regulation Of Cell Differentiation
Pathways		Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production Degradation of CDH1
Drugs		Copper
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 30591961) Response to alcohol consumption (flushing response) ( 29460428) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		112 interacting genes: ACTN2 ADH1B ADRB2 AGTRAP AR ARRDC3 ATG14 ATG5 AURKB BCL2L11 BECN1 BIRC6 BRCA1 CCNA1 CDKN1A CHERP CLEC1B CNOT2 CRMP1 CSF2RB DDX19B DNM1 DYNLL1 EED EIF6 ELOB EP300 EPOR ESR1 ESS2 FYN GABRB3 GATA4 GGN GNB1 GOLM1 GPBP1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 KLHL20 LRP12 MAPK6 MCPH1 MKRN2 MTNR1A NFATC1 NR3C1 NSMAF OLA1 PABPC1 PDE4D PIK3R4 PLCG1 PLEC PRKAA1 PRKAB2 PRKAR2A PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SLC9A5 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TENM1 TMEM131 TNFRSF1A TP63 TP73 TSC22D4 TUBB TUBG1 TYK2 USP40 USP54 WDR83 ZSCAN12	9 interacting genes: ACTN2 CUL4A CUL4B DCAF4 MYOT NFKBIA RACK1 SNAPIN ZFYVE9
Entrez ID		10399	7982
HPRD ID		01503	09015
Ensembl ID		ENSG00000204628	ENSG00000004866
Uniprot IDs		E9KL35 P63244	B7Z4L1 B7Z4U3 E7EPD9 E7EPW5 G3XAH9 H7BXS2 Q9NRC1 X5DRA0
PDB IDs		4AOW 4UG0 4V5Z 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7NWH 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Receptor Complex Regulation Of Intracellular Signal Transduction Protein Kinase Binding Plasma Membrane Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Regulation Of Programmed Cell Death Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Developmental Process Regulation Of Apoptotic Process Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Angiogenesis Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Positive Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Intracellular Signaling Cassette Cellular Response To Hormone Stimulus Negative Regulation Of Apoptotic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Reactive Oxygen Species Metabolic Process Transcription Corepressor Binding Phosphorylation Developmental Process Enzyme Binding Positive Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Glycolytic Process Protein Phosphorylation Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Signal Transduction Response To Hormone	Cul4-RING E3 Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Regulation Of Cellular Localization Positive Regulation Of Protein Catabolic Process Protein Ubiquitination Structural Constituent Of Muscle Regulation Of Intracellular Transport Protein Modification By Small Protein Conjugation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Actin Filament Uncapping Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Late Endosome To Lysosome Transport Post-translational Protein Modification Titin Z Domain Binding Negative Regulation Of Transport Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To UV Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Phospholipase C-activating Angiotensin-activated Signaling Pathway I-kappaB/NF-kappaB Complex Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Light Stimulus Ribosome Biogenesis Positive Regulation Of Mitotic Cell Cycle Microspike Assembly Z Disc Positive Regulation Of Intracellular Transport FATZ Binding Regulation Of Vesicle-mediated Transport Mitotic Cell Cycle Phase Transition Positive Regulation Of Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal Negative Regulation Of Translational Elongation Terminal Button Organization Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Response To UV Cell Cycle Phase Transition Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Golgi To Plasma Membrane Protein Transport BH3 Domain Binding
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