RACK1 and RHOA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RACK1	RHOA
Description		receptor for activated C kinase 1	ras homolog family member A
Image
GO Annotations	Cellular Component	Phagocytic Cup Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ribosome Plasma Membrane Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Midbody Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome IRE1-RACK1-PP2A Complex Ribonucleoprotein Complex	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Membrane Lamellipodium Cell Junction Dendrite Midbody Secretory Granule Membrane Vesicle Cleavage Furrow Ruffle Membrane Cell Projection Dendritic Spine Apical Junction Complex Extracellular Exosome Cell Periphery Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane
	Molecular Function	RNA Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Enzyme Activator Activity Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Tyrosine Kinase Inhibitor Activity Cyclin Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Translation Regulator Activity Cadherin Binding BH3 Domain Binding Molecular Adaptor Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin Binding Protein Kinase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Cytoplasmic Translation Translation Regulation Of Translation Apoptotic Process Gastrulation Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Pigmentation Positive Regulation Of GTPase Activity Negative Regulation Of Smoothened Signaling Pathway Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Rescue Of Stalled Ribosome Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Regulation Of Establishment Of Cell Polarity Positive Regulation Of Gastrulation Negative Regulation Of Translational Frameshifting Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitotic Cytokinesis Cell Morphogenesis Neuron Migration Kidney Development Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Alpha-beta T Cell Lineage Commitment Regulation Of Systemic Arterial Blood Pressure By Endothelin Aortic Valve Formation Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Cell Adhesion Cell-matrix Adhesion Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Skeletal Muscle Tissue Development Negative Regulation Of Cell-substrate Adhesion Regulation Of Neuron Projection Development Cell Migration Substantia Nigra Development Cerebral Cortex Cell Migration Forebrain Radial Glial Cell Differentiation Actin Cytoskeleton Organization Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Androgen Receptor Signaling Pathway Cytoplasmic Microtubule Organization Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Osteoblast Proliferation Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Roundabout Signaling Pathway Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Stress Fiber Assembly Apical Junction Assembly Beta Selection Endothelial Cell Migration Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Neuron Differentiation Negative Regulation Of Cell Size Positive Regulation Of Alpha-beta T Cell Differentiation Negative Chemotaxis Cell Division Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lipase Activity Bone Trabecula Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Semaphorin-plexin Signaling Pathway Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mitotic Spindle Assembly Negative Regulation Of Oxidative Phosphorylation Motor Neuron Apoptotic Process Endothelial Tube Lumen Extension Regulation Of Modification Of Postsynaptic Structure Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Skeletal Muscle Satellite Cell Migration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Mitotic Cleavage Furrow Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cellular Response To Chemokine Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of T Cell Migration Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production Degradation of CDH1	GPVI-mediated activation cascade Axonal growth inhibition (RHOA activation) PI3K/AKT activation Axonal growth stimulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G beta:gamma signalling through PI3Kgamma EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse PCP/CE pathway G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins Ovarian tumor domain proteases ERBB2 Regulates Cell Motility Neutrophil degranulation PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOC GTPase cycle
Drugs		Copper	Guanosine-5'-Diphosphate
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 28714974 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Gut microbiota (functional units) ( 27694959) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Morning person ( 30696823) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		112 interacting genes: ACTN2 ADH1B ADRB2 AGTRAP AR ARRDC3 ATG14 ATG5 AURKB BCL2L11 BECN1 BIRC6 BRCA1 CCNA1 CDKN1A CHERP CLEC1B CNOT2 CRMP1 CSF2RB DDX19B DNM1 DYNLL1 EED EIF6 ELOB EP300 EPOR ESR1 ESS2 FYN GABRB3 GATA4 GGN GNB1 GOLM1 GPBP1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 KLHL20 LRP12 MAPK6 MCPH1 MKRN2 MTNR1A NFATC1 NR3C1 NSMAF OLA1 PABPC1 PDE4D PIK3R4 PLCG1 PLEC PRKAA1 PRKAB2 PRKAR2A PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SLC9A5 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TENM1 TMEM131 TNFRSF1A TP63 TP73 TSC22D4 TUBB TUBG1 TYK2 USP40 USP54 WDR83 ZSCAN12	124 interacting genes: AGAP1 AGAP2 AKAP13 ANKS1B ARAP2 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP26 ARHGAP29 ARHGAP31 ARHGAP32 ARHGAP40 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 ARHGEF5 BCR BIRC2 BMAL1 CAV1 CEBPA CIT CLOCK CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DLC1 DOCK7 DVL2 FLNA FMN2 GMIP HSPA1A ICMT IKBKG IKZF3 ITPR1 KCNA2 KCTD13 KTN1 LRP2 LUC7L2 MCF2 MCF2L MPRIP MYO9A NET1 NGEF NOTCH1 OPHN1 OTUB1 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PLEKHG4 PLEKHG6 PPP1R12A PREX1 PREX2 PRKACA PRKCA PRKCZ PTPRF RABAC1 RACK1 RAP1GDS1 RASGRF1 RASGRF2 RASSF1 RHPN1 RHPN2 RIPOR2 ROCK1 RPN2 RTKN SH3BP1 SLC13A1 SMAD2 SMURF1 SNCA SPRED2 SRGAP1 STARD8 TGFBR1 TGM2 TIAM1 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3
Entrez ID		10399	387
HPRD ID		01503	01323
Ensembl ID		ENSG00000204628	ENSG00000067560
Uniprot IDs		E9KL35 P63244	A0A024R324 A0A7I2YQV1 B4DKN9 C9JRM1 C9JX21 P61586 Q9BVT0
PDB IDs		4AOW 4UG0 4V5Z 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7NWH 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06 4D0N 4XH9 4XOI 4XSG 4XSH 5A0F 5BWM 5C2K 5C4M 5EZ6 5FR1 5FR2 5HPY 5IRC 5JCP 5JHG 5JHH 5M6X 5M70 5ZHX 6BC0 6BCA 6BCB 6KX2 6KX3 6R3V 6V6M 6V6U 6V6V 7G80 7G81 7G82 7G83 7G84 7G85 7G86 7G87 7G88 7G89 7G8A 7G8B 7G8C 7G8D 7G8E 7G8F 7G8G 7G8H 7G8I 7G8J 7G8K 7G8L 7G8M 7G8N 7G8O 7G8P 7G8Q 7G8R 7G8S 7G8T 7G8U 7G8V 7G8W 7G8X 7G8Y 7G8Z 7G90 7G91 7G92 7G93 7G94 7G95 7G96 7G97 7G98 7G99 7G9A 7G9B 7G9C 7G9D 7G9E 7G9F 7G9G 7G9H 7G9I 7G9J 7QSC 7QTM 7WZA 7WZC 8BNT 8FC7 8FC9 8FCB 8FPW 8FPX 8GI3 8GI6 8JVJ 8T1C 9AX5
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Receptor Complex Regulation Of Intracellular Signal Transduction Protein Kinase Binding Plasma Membrane Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Regulation Of Programmed Cell Death Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Developmental Process Regulation Of Apoptotic Process Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Angiogenesis Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Positive Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Intracellular Signaling Cassette Cellular Response To Hormone Stimulus Negative Regulation Of Apoptotic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Reactive Oxygen Species Metabolic Process Transcription Corepressor Binding Phosphorylation Developmental Process Enzyme Binding Positive Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Glycolytic Process Protein Phosphorylation Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Signal Transduction Response To Hormone	Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction GTPase Activator Activity Guanyl-nucleotide Exchange Factor Activity Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Cytosol Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Rho Protein Signal Transduction Small GTPase Binding Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Cytoplasm Actin Filament-based Process Regulation Of Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Cell Migration Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytoskeleton Organization Regulation Of Actin Filament Organization Cell Projection Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Organelle Organization Cell Motility Regulation Of Stress Fiber Assembly Positive Regulation Of Small GTPase Mediated Signal Transduction Anchoring Junction Regulation Of GTPase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Rho GDP-dissociation Inhibitor Activity Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Serine/threonine Kinase Inhibitor Activity Cell Projection Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Rho Protein Signal Transduction
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