GNB2L1 and NSMAF

Number of citations of the paper that reports this interaction (PMID 12391233)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		GNB2L1	NSMAF
Gene Name		guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	neutral sphingomyelinase (N-SMase) activation associated factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Small Ribosomal Subunit Dendrite Midbody Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Endomembrane System Extrinsic Component Of Membrane
	Molecular Function	Protein Kinase C Binding Receptor Binding Protein Binding Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding Protein Complex Scaffold SH2 Domain Binding Protein Homodimerization Activity Poly(A) RNA Binding	Receptor Signaling Protein Activity Protein Binding Phospholipid Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Gastrulation Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of CAMP Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Homooligomerization Regulation Of Protein Localization Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Establishment Of Cell Polarity Positive Regulation Of Gastrulation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Ceramide Metabolic Process Signal Transduction Endosomal Transport Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		86 interactors: ADH1B ADRB2 AGTRAP AR AURKB BCL2L11 CCNA1 CDKN1A CHERP CSF2RB DDX19B DGCR14 DNM1 DYNLL1 EIF6 EPOR FBXW7 FYN GABRB3 GNB1 GOLM1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IFNR IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 LARP4B LRP12 MAPK6 MKRN2 NFATC1 NR3C1 NSMAF PABPC1 PDE4D PLCG1 PLEC PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TCEB1 TCEB2 TNFRSF1A TP63 TP73 TSC22D4 TUBB TYK2 WDR83	4 interactors: ACTB CD40 GNB2L1 TNFRSF1A
Entrez ID		10399	8439
HPRD ID		01503	09117
Ensembl ID		ENSG00000204628	ENSG00000035681
Uniprot IDs		E9KL35 P63244	Q92636
PDB IDs		3J3A 4AOW
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Cellular Response To Stimulus Signal Transduction Response To Stimulus Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Intracellular Signal Transduction Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Response To External Stimulus Defense Response Viral Process Response To Stress Immune System Process Regulation Of Immune Response Regulation Of Body Fluid Levels Regulation Of Cell Proliferation Regulation Of Immune System Process Response To Abiotic Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Response To Cytokine Regulation Of Cell Death Regulation Of Cellular Process Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Platelet Activation Innate Immune Response Immune Response Regulation Of Phosphorylation Blood Coagulation Regulation Of Apoptotic Process Hemostasis Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transport Peptidyl-tyrosine Autophosphorylation Cellular Process Neurotrophin TRK Receptor Signaling Pathway Developmental Process Regulation Of Angiogenesis Positive Regulation Of Cellular Metabolic Process	Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of JAK-STAT Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of JAK-STAT Cascade Regulation Of Establishment Of Protein Localization Response To Wounding Positive Regulation Of Protein Phosphorylation Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of CAMP Catabolic Process Regulation Of Cellular Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Phosphorylation Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Response To Mechanical Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Phosphorylation Defense Response Regulation Of Neuron Death Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Response To Lipopolysaccharide Regulation Of Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Isotype Switching To IgG Isotypes Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Regulation Of Isotype Switching To IgG Isotypes Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Tagcloud ?		aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	alternatively arrestin axin crystallin dissimilar endproducts gaiix glycation illumina microvasculature nondiabetic photoreceptor physiologically pointing rage retinopathy rodent seq sgip1 sh3 signatures sphingomyelinase spliced streptozotocin transcriptome transcripts utilize versions xenobiotic
Tagcloud (Difference) ?		aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	alternatively arrestin axin crystallin dissimilar endproducts gaiix glycation illumina microvasculature nondiabetic photoreceptor physiologically pointing rage retinopathy rodent seq sgip1 sh3 signatures sphingomyelinase spliced streptozotocin transcriptome transcripts utilize versions xenobiotic
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