TAF9 and KLF6

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (proximity labelling technology, pull down)

		TAF9	KLF6
Description		TATA-box binding protein associated factor 9	KLF transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFTC Complex Pre-snoRNP Complex MLL1 Complex	Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding P53 Binding DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Protein Heterodimerization Activity ATPase Binding C2H2 Zinc Finger Domain Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Box C/D SnoRNP Assembly Regulation Of DNA Repair Chromatin Remodeling DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome HATs acetylate histones RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS			Asthma (bronchodilator response) ( 23508266) Coronary artery calcification ( 23870195) Diastolic blood pressure ( 27841878) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 28869591 30598549) Height ( 33713608) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Plasma anti-thyroglobulin levels ( 29678681) Red blood cell count ( 32888494)
Interacting Genes		57 interacting genes: AHR ANK2 APP CEBPB CIITA COIL DRAP1 EEF1A1 ELF3 FBL FBLN1 FEZ1 GALNT6 GLI1 GLI2 GLI3 GTF2B H3-4 HCFC1 HNF4A HSF1 KLF6 KMT2A KPNA1 KPNA6 LAMTOR5 MAGEC2 MYC NCOA2 NCOR1 NDRG1 NFATC2 NR1D2 NUFIP1 PJA1 RBM48 RELA RNF138 RPS14 RPS24 RUVBL1 RUVBL2 SF3B3 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF6L TAF7 TAF8 TBCA TP53 UBA1	16 interacting genes: APOM APP CELSR2 EHMT2 FBL GTF3C1 HDAC3 KLF4 LCOR NOP56 NUFIP1 PNO1 POLA2 SP1 TAF9 TP53
Entrez ID		6880	1316
HPRD ID		15983	03632
Ensembl ID		ENSG00000273841	ENSG00000067082
Uniprot IDs		Q16594	D3GC14 Q99612
PDB IDs		6F3T 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8H7G 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIID Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II MRNA Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process TBP-class Protein Binding Protein-DNA Complex Assembly MLL1 Complex Nucleic Acid Metabolic Process Transcription Factor TFTC Complex Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Metabolic Process Protein Heterodimerization Activity Protein-containing Complex Assembly Protein-containing Complex Organization Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Repair	Pre-snoRNP Complex Histone Deacetylase Binding Nucleoplasm DNA Binding Box C/D Methylation Guide SnoRNP Complex RNA Metabolic Process Transcription Corepressor Binding Chromatin Remodeling Positive Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway Small-subunit Processome TFIID-class Transcription Factor Complex Binding Ribosomal Small Subunit Biogenesis DNA-templated Transcription Transcription Repressor Complex Box C/D SnoRNP Assembly P53 Binding Promoter-specific Chromatin Binding Regulation Of MiRNA Transcription Nucleus Chromatin Organization Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II ATPase Binding RRNA Metabolic Process C2H2 Zinc Finger Domain Binding Cellular Response To Oxygen-containing Compound Low-density Lipoprotein Particle Nucleobase-containing Compound Biosynthetic Process Transcription Cis-regulatory Region Binding Histone Methyltransferase Binding Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleolus Ubiquitin-specific Protease Binding Very-low-density Lipoprotein Particle Negative Regulation Of Transcription By RNA Polymerase II SnoRNA Binding Nucleic Acid Metabolic Process High-density Lipoprotein Particle RRNA Transcription Regulation Of RNA Metabolic Process Molecular Function Activator Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Lipoprotein Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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