TAF9 and GLI3

Number of citations of the paper that reports this interaction (PubMedID 26282181)
52

Data Source:
BioGRID (pull down)

		TAF9	GLI3
Description		TATA-box binding protein associated factor 9	GLI family zinc finger 3
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GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFTC Complex Pre-snoRNP Complex MLL1 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Axoneme Nuclear Speck Transcription Repressor Complex Cell Projection Ciliary Tip Ciliary Base GLI-SUFU Complex
	Molecular Function	Transcription Cis-regulatory Region Binding P53 Binding DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Protein Heterodimerization Activity ATPase Binding C2H2 Zinc Finger Domain Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Histone Acetyltransferase Binding Mediator Complex Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Box C/D SnoRNP Assembly Regulation Of DNA Repair Chromatin Remodeling DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Kidney Development Positive Regulation Of Neuroblast Proliferation Chondrocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Smoothened Signaling Pathway Pattern Specification Process Neuroblast Proliferation Axon Guidance Central Nervous System Development Brain Development Hindgut Morphogenesis Heart Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Gene Expression Regulation Of Gene Expression Protein Processing Spinal Cord Dorsal/ventral Patterning Spinal Cord Motor Neuron Differentiation Telencephalon Development Pallium Development Subpallium Development Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex Radial Glia-guided Migration Layer Formation In Cerebral Cortex Forebrain Radial Glial Cell Differentiation Neural Tube Development Central Nervous System Neuron Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Embryonic Limb Morphogenesis Mammary Gland Development Forebrain Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Tube Development Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Camera-type Eye Development Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Negative Thymic T Cell Selection Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Embryonic Neurocranium Morphogenesis Embryonic Skeletal System Morphogenesis Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Roof Of Mouth Development Limb Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Vocalization Behavior Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Larynx Morphogenesis Regulation Of Bone Development Negative Regulation Of Stem Cell Proliferation
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome HATs acetylate histones RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates osteoblast differentiation
Drugs
Diseases			Acrocallosal syndrome; Greig cephalopolysyndactyly syndrome Pallister-Hall syndrome
GWAS			Age-related macular degeneration ( 23326517) Allergic rhinitis ( 22036096) Appendicular lean mass ( 33097823) Asthma ( 29273806) Dietary fat liking ( 32516399) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Emotional recognition ( 31596458) facial morphology traits (multivariate analysis) ( 27193062) Health literacy ( 31250787) Hip index ( 34021172) Language performance in older adults (adjusted for episodic memory) ( 28577822) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Metabolite levels ( 23823483) middle facial morphology traits (quantitative measurement) ( 27193062) Refractive error ( 32231278) Response to resistance training (vastus lateralis fiber area change) ( 33891350)
Interacting Genes		57 interacting genes: AHR ANK2 APP CEBPB CIITA COIL DRAP1 EEF1A1 ELF3 FBL FBLN1 FEZ1 GALNT6 GLI1 GLI2 GLI3 GTF2B H3-4 HCFC1 HNF4A HSF1 KLF6 KMT2A KPNA1 KPNA6 LAMTOR5 MAGEC2 MYC NCOA2 NCOR1 NDRG1 NFATC2 NR1D2 NUFIP1 PJA1 RBM48 RELA RNF138 RPS14 RPS24 RUVBL1 RUVBL2 SF3B3 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF6L TAF7 TAF8 TBCA TP53 UBA1	19 interacting genes: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA RHOU SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TAF9 TWIST1 ZIC1 ZIC2 ZIC3
Entrez ID		6880	2737
HPRD ID		15983	01313
Ensembl ID		ENSG00000273841	ENSG00000106571
Uniprot IDs		Q16594	A0A2R8YGX0 P10071
PDB IDs		6F3T 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8H7G 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	4BLD
Enriched GO Terms of Interacting Partners?		RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIID Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II MRNA Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process TBP-class Protein Binding Protein-DNA Complex Assembly MLL1 Complex Nucleic Acid Metabolic Process Transcription Factor TFTC Complex Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Metabolic Process Protein Heterodimerization Activity Protein-containing Complex Assembly Protein-containing Complex Organization Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Repair	Embryonic Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription SMAD Protein Complex Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Pattern Specification Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process I-SMAD Binding Regulation Of Primary Metabolic Process Animal Organ Development Positive Regulation Of Metabolic Process Embryonic Pattern Specification Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression DNA-binding Transcription Factor Binding Regulation Of Smoothened Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Endoderm Development Regulation Of Cell Communication Regulation Of Signaling Regulation Of Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Catabolic Process Tissue Morphogenesis Transcription Regulator Complex Gastrulation Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Co-SMAD Binding DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Primary MiRNA Processing RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regionalization Nucleoplasm
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