TAF9 and RUVBL2

Number of citations of the paper that reports this interaction (PubMedID 17636026)
56

Data Source:
BioGRID (pull down)

		TAF9	RUVBL2
Description		TATA-box binding protein associated factor 9	RuvB like AAA ATPase 2
Image
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFTC Complex Pre-snoRNP Complex MLL1 Complex	Nucleosome Euchromatin Swr1 Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Ciliary Basal Body Extracellular Exosome MLL1 Complex R2TP Complex Protein Folding Chaperone Complex Dynein Axonemal Particle RPAP3/R2TP/prefoldin-like Complex Ribonucleoprotein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding P53 Binding DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Protein Heterodimerization Activity ATPase Binding C2H2 Zinc Finger Domain Binding DNA-binding Transcription Factor Binding	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding Beta-catenin Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity TBP-class Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Unfolded Protein Binding ATPase Binding Promoter-enhancer Loop Anchoring Activity
	Biological Process	Box C/D SnoRNP Assembly Regulation Of DNA Repair Chromatin Remodeling DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Box C/D SnoRNP Assembly Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding DNA Damage Response Regulation Of Chromosome Organization Cellular Response To UV Regulation Of Apoptotic Process Positive Regulation Of DNA Repair Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Protein Stabilization Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome HATs acetylate histones RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Telomere Extension By Telomerase HATs acetylate histones
Drugs			Quercetin
Diseases
GWAS
Interacting Genes		57 interacting genes: AHR ANK2 APP CEBPB CIITA COIL DRAP1 EEF1A1 ELF3 FBL FBLN1 FEZ1 GALNT6 GLI1 GLI2 GLI3 GTF2B H3-4 HCFC1 HNF4A HSF1 KLF6 KMT2A KPNA1 KPNA6 LAMTOR5 MAGEC2 MYC NCOA2 NCOR1 NDRG1 NFATC2 NR1D2 NUFIP1 PJA1 RBM48 RELA RNF138 RPS14 RPS24 RUVBL1 RUVBL2 SF3B3 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF6L TAF7 TAF8 TBCA TP53 UBA1	34 interacting genes: AGR2 AKT1 APP APPL1 APPL2 ATF2 BCL3 CDKN2A CEBPA CTNNB1 DNAAF19 DNAJB4 DPCD EHMT2 EP300 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MCPH1 MDM2 NDRG1 OGT RUVBL1 STOM TAF9 TBP TERT TXNIP UBR5 YWHAQ
Entrez ID		6880	10856
HPRD ID		15983	16070
Ensembl ID		ENSG00000273841	ENSG00000183207
Uniprot IDs		Q16594	B3KNL2 Q9Y230
PDB IDs		6F3T 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8H7G 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	2CQA 2XSZ 3UK6 5OAF 6FO1 6H7X 6HTS 6IGM 6K0R 6QI8 6QI9 7AHO 7OLE 7P6X 7ZI4 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C57 9C62 9EMA 9EMC
Enriched GO Terms of Interacting Partners?		RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIID Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II MRNA Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process TBP-class Protein Binding Protein-DNA Complex Assembly MLL1 Complex Nucleic Acid Metabolic Process Transcription Factor TFTC Complex Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Metabolic Process Protein Heterodimerization Activity Protein-containing Complex Assembly Protein-containing Complex Organization Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Repair	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein-containing Complex Negative Regulation Of Transcription By RNA Polymerase II Protein Localization To Organelle DNA-binding Transcription Factor Binding Positive Regulation Of Gene Expression Response To Stress Protein Import Into Nucleus Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Import Into Nucleus Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process P53 Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Developmental Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Metal Ion Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Nucleocytoplasmic Transport Nuclear Transport Regulation Of Cellular Localization Regulation Of Protein Localization To Nucleus Nucleus
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