AP2M1 and AQP4

Number of citations of the paper that reports this interaction (PMID 11742978)
29

Data Source:
HPRD (in vitro)

		AP2M1	AQP4
Gene Name		adaptor-related protein complex 2, mu 1 subunit	aquaporin 4
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Basolateral Plasma Membrane T-tubule Protein Complex
	Molecular Function	Signal Sequence Binding Transporter Activity Protein Binding Lipid Binding Clathrin Adaptor Activity Low-density Lipoprotein Particle Receptor Binding	Water Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Porin Activity
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Membrane Organization Clathrin-mediated Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane	Renal Water Homeostasis Transport Water Transport Female Pregnancy Sensory Perception Of Sound Response To Radiation Cellular Water Homeostasis Carbon Dioxide Transport Glycerol Transport Ion Transmembrane Transport Hyperosmotic Salinity Response Multicellular Organismal Water Homeostasis Protein Homooligomerization Response To Glucocorticoid Transmembrane Transport Renal Water Absorption Cellular Response To Interferon-gamma Cellular Response To Estradiol Stimulus
Pathways		Retrograde neurotrophin signalling Axon guidance Gap junction degradation HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Formation of annular gap junctions Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Nef mediated downregulation of CD28 cell surface expression Gap junction trafficking Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Aquaporin-mediated transport
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Protein-Protein Interactions		40 interactors: ADRA1B AP2B1 AQP4 ARRB2 ATXN1L CACNA1A CD22 CD3D CDK11B CORO7 CSNK2B CTLA4 DAB2 DCX DPPA2 DVL2 EHD2 FAM208A FURIN FXR2 GAK GRIN2B IKZF1 KCNJ11 LAMP1 LY9 MED4 MEGF10 NCOR2 NDRG1 RALBP1 RPL38 RRP12 RSPH14 RUNDC3A STON2 SYNJ1 TBC1D5 TGOLN2 ZBTB8A	4 interactors: AP2M1 AP3M1 CSNK2A1 CSNK2A2
Entrez ID		1173	361
HPRD ID		03014	02631
Ensembl ID		ENSG00000161203	ENSG00000171885
Uniprot IDs		E9PFW3 Q96CW1	F1DSG4 P55087
PDB IDs		1H6E	3GD8
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Regulation Of Cellular Process System Development Organ Development Endocytosis Signaling Regulation Of Endocytosis Cell Communication Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Transport Protein Localization Developmental Process Positive Regulation Of Transport Cellular Response To Transforming Growth Factor Beta Stimulus Signal Transduction Response To Transforming Growth Factor Beta Cell Differentiation Synaptic Transmission Cell Development Establishment Of Protein Localization Chemotaxis Neurological System Process Regulation Of Signaling Cell-cell Signaling Cellular Response To Stimulus Nervous System Development Positive Regulation Of Receptor Internalization Regulation Of Androgen Receptor Signaling Pathway Establishment Of Localization In Cell Cellular Localization Single-organism Behavior Tube Development Behavioral Response To Pain Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Morphogenesis Involved In Differentiation Cell Proliferation Regulation Of Metabolic Process Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Membrane Potential Tissue Development Response To Stimulus Response To Estradiol Brain Development Protein Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Receptor Internalization	Mitotic Spindle Checkpoint Movement Of Cell Or Subcellular Component Axon Guidance Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Axonogenesis Negative Regulation Of Proteasomal Protein Catabolic Process Axon Development Negative Regulation Of Cellular Protein Catabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Neuron Projection Morphogenesis Negative Regulation Of Chromosome Organization Cell Morphogenesis Involved In Differentiation Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Neuron Development Mitotic Cell Cycle Checkpoint Cell Morphogenesis Regulation Of Proteasomal Protein Catabolic Process Neuron Differentiation Regulation Of Chromosome Organization Cell Projection Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Locomotion Regulation Of Cell Division Wnt Signaling Pathway Generation Of Neurons Negative Regulation Of Proteolysis Neurogenesis Negative Regulation Of Protein Processing Regulation Of Protein Catabolic Process Regulation Of Protein Processing Cell Development Response To External Stimulus Regulation Of Mitotic Cell Cycle
Tagcloud ?		chemiluminescent chose escc ftl gearray gearrays gncpro guideline highlighted hla hspa8 immuno iran iranian locate mmp2 modalities modulatory northeast online prove rap1a tailed tp53i3 ube2l6 underexpressed verified verify xrcc5	3rds aquaporin blindness contiguous demyelinating edss gray holocord ig longitudinally malaysia monophasic myelitis neuritis neuromyelitis nmo nmosd optic optica paroxysmal relapses relapsing seronegative seropositive seropositivity spasms tonic transverse vertebral
Tagcloud (Difference) ?		chemiluminescent chose escc ftl gearray gearrays gncpro guideline highlighted hla hspa8 immuno iran iranian locate mmp2 modalities modulatory northeast online prove rap1a tailed tp53i3 ube2l6 underexpressed verified verify xrcc5	3rds aquaporin blindness contiguous demyelinating edss gray holocord ig longitudinally malaysia monophasic myelitis neuritis neuromyelitis nmo nmosd optic optica paroxysmal relapses relapsing seronegative seropositive seropositivity spasms tonic transverse vertebral
Tagcloud (Intersection) ?