AP2M1 and DCX

Number of citations of the paper that reports this interaction (PMID 11591131)
10

Data Source:
HPRD (two hybrid, in vitro)

		AP2M1	DCX
Gene Name		adaptor-related protein complex 2, mu 1 subunit	doublecortin
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome	Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Neuron Projection
	Molecular Function	Signal Sequence Binding Transporter Activity Protein Binding Lipid Binding Clathrin Adaptor Activity Low-density Lipoprotein Particle Receptor Binding	Protein Binding Microtubule Binding Protein Kinase Binding
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Membrane Organization Clathrin-mediated Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane	Neuron Migration Nervous System Development Axon Guidance Central Nervous System Development Brain Development Central Nervous System Projection Neuron Axonogenesis Intracellular Signal Transduction Axon Extension Dendrite Morphogenesis
Pathways		Retrograde neurotrophin signalling Axon guidance Gap junction degradation HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Formation of annular gap junctions Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Nef mediated downregulation of CD28 cell surface expression Gap junction trafficking Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System	Axon guidance Neurofascin interactions L1CAM interactions
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Protein-Protein Interactions		40 interactors: ADRA1B AP2B1 AQP4 ARRB2 ATXN1L CACNA1A CD22 CD3D CDK11B CORO7 CSNK2B CTLA4 DAB2 DCX DPPA2 DVL2 EHD2 FAM208A FURIN FXR2 GAK GRIN2B IKZF1 KCNJ11 LAMP1 LY9 MED4 MEGF10 NCOR2 NDRG1 RALBP1 RPL38 RRP12 RSPH14 RUNDC3A STON2 SYNJ1 TBC1D5 TGOLN2 ZBTB8A	29 interactors: ACD AP1M1 AP2M1 APP CALCOCO2 CDK5 FBXO25 GOLGA2 IKZF1 KIFC3 KRT40 KRTAP10-8 MEOX1 MID2 NFASC PAFAH1B1 POT1 PPP1CA PPP1R9B RINT1 SPAG5 SPP1 TERF1 TINF2 TRIM23 TRIM27 TRIM39 USP9X ZBTB5
Entrez ID		1173	1641
HPRD ID		03014	02127
Ensembl ID		ENSG00000161203	ENSG00000077279
Uniprot IDs		E9PFW3 Q96CW1	A8K340 B4DM53 O43602
PDB IDs		1H6E	1MJD 2BQQ 2XRP 4ATU
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Regulation Of Cellular Process System Development Organ Development Endocytosis Signaling Regulation Of Endocytosis Cell Communication Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Transport Protein Localization Developmental Process Positive Regulation Of Transport Cellular Response To Transforming Growth Factor Beta Stimulus Signal Transduction Response To Transforming Growth Factor Beta Cell Differentiation Synaptic Transmission Cell Development Establishment Of Protein Localization Chemotaxis Neurological System Process Regulation Of Signaling Cell-cell Signaling Cellular Response To Stimulus Nervous System Development Positive Regulation Of Receptor Internalization Regulation Of Androgen Receptor Signaling Pathway Establishment Of Localization In Cell Cellular Localization Single-organism Behavior Tube Development Behavioral Response To Pain Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Morphogenesis Involved In Differentiation Cell Proliferation Regulation Of Metabolic Process Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Membrane Potential Tissue Development Response To Stimulus Response To Estradiol Brain Development Protein Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Receptor Internalization	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Cell Cycle Negative Regulation Of Chromosome Organization Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process Regulation Of Organelle Organization Cell Division Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Biosynthetic Process Organelle Organization Regulation Of DNA Replication Regulation Of Developmental Growth Protein Localization To Chromosome, Telomeric Region Telomere Capping Regulation Of DNA Biosynthetic Process Movement Of Cell Or Subcellular Component Axonogenesis Cellular Component Assembly Protein Localization Positive Regulation Of Telomerase Activity Neuron Projection Development Cellular Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Regulation Of Growth Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Negative Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Neuron Development Immune System Process Positive Regulation Of Telomere Maintenance Hippocampus Development Positive Regulation Of Organelle Organization Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Cell Morphogenesis Involved In Differentiation Forebrain Development Developmental Cell Growth Negative Regulation Of Viral Release From Host Cell Neuron Differentiation
Tagcloud ?		chemiluminescent chose escc ftl gearray gearrays gncpro guideline highlighted hla hspa8 immuno iran iranian locate mmp2 modalities modulatory northeast online prove rap1a tailed tp53i3 ube2l6 underexpressed verified verify xrcc5	17p13 classical deletions disrupt epilepsy frontal gradient lis lis1 lissencephaly malformation mutations occipital overlapping parietal proline q23 repeats retardation sequencing sexes southern splice sporadic though truncation wd40 xlis xq22
Tagcloud (Difference) ?		chemiluminescent chose escc ftl gearray gearrays gncpro guideline highlighted hla hspa8 immuno iran iranian locate mmp2 modalities modulatory northeast online prove rap1a tailed tp53i3 ube2l6 underexpressed verified verify xrcc5	17p13 classical deletions disrupt epilepsy frontal gradient lis lis1 lissencephaly malformation mutations occipital overlapping parietal proline q23 repeats retardation sequencing sexes southern splice sporadic though truncation wd40 xlis xq22
Tagcloud (Intersection) ?