AP2M1 and MEGF10

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		AP2M1	MEGF10
Gene Name		adaptor-related protein complex 2, mu 1 subunit	multiple EGF-like-domains 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome	Phagocytic Cup Integral Component Of Membrane Basolateral Plasma Membrane Cell Projection
	Molecular Function	Signal Sequence Binding Transporter Activity Protein Binding Lipid Binding Clathrin Adaptor Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Membrane Organization Clathrin-mediated Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane	Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Homotypic Cell-cell Adhesion Recognition Of Apoptotic Cell Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Muscle Cell Development
Pathways		Retrograde neurotrophin signalling Axon guidance Gap junction degradation HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Formation of annular gap junctions Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Nef mediated downregulation of CD28 cell surface expression Gap junction trafficking Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		40 interactors: ADRA1B AP2B1 AQP4 ARRB2 ATXN1L CACNA1A CD22 CD3D CDK11B CORO7 CSNK2B CTLA4 DAB2 DCX DPPA2 DVL2 EHD2 FAM208A FURIN FXR2 GAK GRIN2B IKZF1 KCNJ11 LAMP1 LY9 MED4 MEGF10 NCOR2 NDRG1 RALBP1 RPL38 RRP12 RSPH14 RUNDC3A STON2 SYNJ1 TBC1D5 TGOLN2 ZBTB8A	22 interactors: AARS2 ALMS1 AP2M1 ARHGAP32 BAHD1 CADPS2 CEP57 CUL7 DHX16 GRB10 HDAC4 ITSN2 KIAA1598 MCF2L2 RANBP10 SART3 SCAPER SNRNP200 TAOK2 TMEM132A VWA8 ZNFX1
Entrez ID		1173	84466
HPRD ID		03014	14384
Ensembl ID		ENSG00000161203	ENSG00000145794
Uniprot IDs		E9PFW3 Q96CW1	Q96KG7
PDB IDs		1H6E
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Regulation Of Cellular Process System Development Organ Development Endocytosis Signaling Regulation Of Endocytosis Cell Communication Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Transport Protein Localization Developmental Process Positive Regulation Of Transport Cellular Response To Transforming Growth Factor Beta Stimulus Signal Transduction Response To Transforming Growth Factor Beta Cell Differentiation Synaptic Transmission Cell Development Establishment Of Protein Localization Chemotaxis Neurological System Process Regulation Of Signaling Cell-cell Signaling Cellular Response To Stimulus Nervous System Development Positive Regulation Of Receptor Internalization Regulation Of Androgen Receptor Signaling Pathway Establishment Of Localization In Cell Cellular Localization Single-organism Behavior Tube Development Behavioral Response To Pain Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Morphogenesis Involved In Differentiation Cell Proliferation Regulation Of Metabolic Process Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Membrane Potential Tissue Development Response To Stimulus Response To Estradiol Brain Development Protein Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Receptor Internalization	Organelle Organization Cellular Component Assembly Positive Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome Positive Regulation Of Histone Deubiquitination Mitochondrial Alanyl-tRNA Aminoacylation RNA Splicing, Via Transesterification Reactions Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Cellular Macromolecular Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Cis Assembly Of Pre-catalytic Spliceosome
Tagcloud ?		chemiluminescent chose escc ftl gearray gearrays gncpro guideline highlighted hla hspa8 immuno iran iranian locate mmp2 modalities modulatory northeast online prove rap1a tailed tp53i3 ube2l6 underexpressed verified verify xrcc5	adhere adopt ap2 ap50 associating autoimmunity ced cerebellum clathrin clearing coated colocalized corpses deeper dishes elucidating engulfment flat immunoblot irregular mirrored mosaic nematode ortholog pits stellate ubiquitinated unusually vacuoles
Tagcloud (Difference) ?		chemiluminescent chose escc ftl gearray gearrays gncpro guideline highlighted hla hspa8 immuno iran iranian locate mmp2 modalities modulatory northeast online prove rap1a tailed tp53i3 ube2l6 underexpressed verified verify xrcc5	adhere adopt ap2 ap50 associating autoimmunity ced cerebellum clathrin clearing coated colocalized corpses deeper dishes elucidating engulfment flat immunoblot irregular mirrored mosaic nematode ortholog pits stellate ubiquitinated unusually vacuoles
Tagcloud (Intersection) ?