PCGF3 and RNF2

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PCGF3	RNF2
Gene Name		polycomb group ring finger 3	ring finger protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex
	Molecular Function	Protein Binding Zinc Ion Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity RING-like Zinc Finger Domain Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Gastrulation With Mouth Forming Second Transcription, DNA-templated Anterior/posterior Axis Specification Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Hemostatic factors and hematological phenotypes ( 22443383)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		12 interactors: BCOR BCORL1 BMI1 CBX6 CBX7 CBX8 DZIP3 PHC2 RING1 RNF2 TRIM9 UBE2C	54 interactors: ABCB1 AMBRA1 BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 HIST1H2AB HIST2H2AA3 HIST2H2AC HIST3H3 KAT8 KMT2A L3MBTL2 MBD1 OTUD6A PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PGP PHB2 PHC1 PSMC4 RING1 RRM1 RYBP SMURF2 SSX2 TARDBP TFCP2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 USP7 WASH1
Entrez ID		10336	6045
HPRD ID		11515	07028
Ensembl ID		ENSG00000185619	ENSG00000121481
Uniprot IDs		B3KWT8 Q3KNV8	B3KRH1 Q99496
PDB IDs			2H0D 3GS2 3H8H 3IXS 3RPG
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Protein Ubiquitination Chromatin Modification Protein Modification By Small Protein Conjugation Chromatin Organization Chromosome Organization Histone H2A Monoubiquitination Histone H2A Ubiquitination Histone Monoubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Protein Monoubiquitination Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Organelle Organization Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Cellular Protein Modification Process Gene Expression Pattern Specification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Anterior/posterior Pattern Specification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Histone H3-K36 Methylation Heterocycle Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Free Ubiquitin Chain Polymerization Negative Regulation Of Tooth Mineralization Negative Regulation Of SNARE Complex Assembly	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Histone Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Catabolic Process Chromatin Modification Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Metabolic Process Chromatin Organization Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Transcription, DNA-templated Chromosome Organization Histone Modification RNA Biosynthetic Process Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Proteolysis Protein Monoubiquitination Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Catabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Macromolecule Biosynthetic Process Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression
Tagcloud ?			aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott
Tagcloud (Difference) ?			aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott
Tagcloud (Intersection) ?