PCGF3 and UBE2C

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		PCGF3	UBE2C
Description		polycomb group ring finger 3	ubiquitin conjugating enzyme E2 C
Image		No pdb structure
GO Annotations	Cellular Component	X Chromosome Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H2AK119 Ubiquitin Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-like Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Random Inactivation Of X Chromosome	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Exit From Mitosis Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemostatic factors and hematological phenotypes ( 22443383) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Schizophrenia ( 33169155) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Type 2 diabetes ( 30297969 32499647) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252 32888494)	Height ( 31562340)
Interacting Genes		11 interacting genes: BMI1 DZIP3 HNRNPK PHC1 PHC2 RING1 TRIM55 TRIM63 TRIM9 UBE2C UBE2D3	36 interacting genes: ANAPC11 ANAPC2 AURKA CDC20 CKAP2 CXCR1 DTX1 ENO2 HECTD3 ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 RAG1 RBX1 RELA RNF167 RNF31 RNF6 RNF7 RYR2 STUB1 TNNC1 TRIM13 TRIM2 TRIM21 TRIM28 TRIM29 UBA1 UBA6 UBASH3B UBC UBE3D
Entrez ID		10336	11065
HPRD ID		11515	05717
Ensembl ID		ENSG00000185619	ENSG00000175063
Uniprot IDs		B3KQ06 B3KWT8 B4DTN5 Q3KNV8	A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3
PDB IDs			1I7K 4YII 5A31 5KHR 5L9U 8TAR 8TAU
Enriched GO Terms of Interacting Partners?		PRC1 Complex Ubiquitin Protein Ligase Activity PcG Protein Complex Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Zinc Ion Binding Sex Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-protein Transferase Activator Activity Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Chromatin Binding Ubiquitin Conjugating Enzyme Activity Protein K11-linked Ubiquitination Metal Ion Binding Heterochromatin Negative Regulation Of Metabolic Process Chromatin Remodeling Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-1 Regulation Of Adaxial/abaxial Pattern Formation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Biosynthetic Process Nuclear Body Chromatin Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process RING-like Zinc Finger Domain Binding Rostrocaudal Neural Tube Patterning Positive Regulation Of Protein Ubiquitination Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Exit From Mitosis Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Primary Metabolic Process Nucleus Response To Glucocorticoid Proteasomal Protein Catabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Modification Process Catabolic Process Protein Polyubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Transferase Activity Protein Monoubiquitination Protein K48-linked Ubiquitination Macromolecule Metabolic Process Ubiquitin-ubiquitin Ligase Activity Cullin Family Protein Binding Protein K6-linked Ubiquitination Protein K63-linked Ubiquitination Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Autophagy Positive Regulation Of Catabolic Process Protein K29-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Zinc Ion Binding Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein K27-linked Ubiquitination Suppression Of Viral Release By Host SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Anaphase-promoting Complex Ubiquitin Activating Enzyme Activity Ubiquitin-like Protein Ligase Activity Anaphase-promoting Complex-dependent Catabolic Process
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