PCGF3 and DZIP3

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		PCGF3	DZIP3
Description		polycomb group ring finger 3	DAZ interacting zinc finger protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	X Chromosome Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H2AK119 Ubiquitin Ligase Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Phosphatase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Random Inactivation Of X Chromosome	Protein Polyubiquitination Protein Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemostatic factors and hematological phenotypes ( 22443383) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Schizophrenia ( 33169155) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Type 2 diabetes ( 30297969 32499647) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252 32888494)	Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		11 interacting genes: BMI1 DZIP3 HNRNPK PHC1 PHC2 RING1 TRIM55 TRIM63 TRIM9 UBE2C UBE2D3	53 interacting genes: AKTIP AP1M1 ARHGAP32 ATXN1 BAG4 BIRC2 BIRC3 CARM1 CCND1 CEP63 DAZ1 FBXO17 GRIP1 GTF2H2C_2 HNRNPF HNRNPH1 HNRNPUL1 HOTAIR HOXC8 MIR20A MIR29C NCOR1 PCGF3 PITX1 RAD18 RBM4B RNF38 RUNX1 TNS2 TOLLIP TRIM21 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2N UBE2R2 UBE2U UBE2V1 UBE2V2 UBE2W UBE2Z UBR3 ZCCHC10 ZNF24 ZNF765
Entrez ID		10336	9666
HPRD ID		11515	10562
Ensembl ID		ENSG00000185619	ENSG00000198919
Uniprot IDs		B3KQ06 B3KWT8 B4DTN5 Q3KNV8	Q86Y13
PDB IDs
Enriched GO Terms of Interacting Partners?		PRC1 Complex Ubiquitin Protein Ligase Activity PcG Protein Complex Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Zinc Ion Binding Sex Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-protein Transferase Activator Activity Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Chromatin Binding Ubiquitin Conjugating Enzyme Activity Protein K11-linked Ubiquitination Metal Ion Binding Heterochromatin Negative Regulation Of Metabolic Process Chromatin Remodeling Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-1 Regulation Of Adaxial/abaxial Pattern Formation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Biosynthetic Process Nuclear Body Chromatin Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process RING-like Zinc Finger Domain Binding Rostrocaudal Neural Tube Patterning Positive Regulation Of Protein Ubiquitination Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Exit From Mitosis Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Primary Metabolic Process Nucleus Response To Glucocorticoid Proteasomal Protein Catabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Monoubiquitination Macromolecule Catabolic Process Protein Modification Process Protein K63-linked Ubiquitination Proteolysis Regulation Of Protein Polyubiquitination Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Protein K11-linked Ubiquitination Transferase Activity Protein Metabolic Process Positive Regulation Of Protein K63-linked Ubiquitination Macromolecule Metabolic Process UBC13-MMS2 Complex Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Postreplication Repair Ubiquitin Conjugating Enzyme Complex Ubiquitin Protein Ligase Activity Nucleus Positive Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process Catabolic Process Nucleoplasm Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ATP Binding DNA Damage Response Positive Regulation Of Protein Metabolic Process Error-free Postreplication DNA Repair Negative Regulation Of Macromolecule Metabolic Process DNA Repair Regulation Of RNA Metabolic Process
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