Wiki-Pi
About
Search
People
Updates
Search
CDKN1A and TK1
Number of citations of the paper that reports this interaction (PubMedID
11389691
)
37
Data Source:
HPRD
(in vitro, in vivo)
CDKN1A
TK1
Description
cyclin dependent kinase inhibitor 1A
thymidine kinase 1
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Body
Protein-containing Complex
PCNA-p21 Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Serine/threonine Kinase Binding
Protein Sequestering Activity
Molecular Function Activator Activity
Molecular Function Inhibitor Activity
Nucleotide Binding
Thymidine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Metal Ion Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
In Utero Embryonic Development
Protein Import Into Nucleus
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Epidermis Development
Response To UV
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of B Cell Proliferation
Mitotic G1 DNA Damage Checkpoint Signaling
Cellular Response To Amino Acid Starvation
Wound Healing
Tissue Regeneration
Signal Transduction In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Programmed Cell Death
Keratinocyte Proliferation
Positive Regulation Of DNA Replication
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Growth
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Import Into Nucleus
Regulation Of Cell Cycle
Cellular Response To Cell-matrix Adhesion
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-B
Signal Transduction By P53 Class Mediator
Cellular Senescence
Replicative Senescence
Stress-induced Premature Senescence
Oncogene-induced Cell Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of DNA Biosynthetic Process
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Nucleobase-containing Compound Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Thymidine Metabolic Process
Thymidine Biosynthetic Process
Protein Homotetramerization
DNA Biosynthetic Process
DNA Synthesis Involved In Mitotic DNA Replication
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Transcriptional regulation by RUNX2
RUNX3 regulates CDKN1A transcription
Neddylation
Transcriptional regulation of granulopoiesis
FOXO-mediated transcription of cell cycle genes
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
G1/S-Specific Transcription
Pyrimidine salvage
Drugs
Valproic acid
Arsenic trioxide
Dithioerythritol
Thymidine 5'-triphosphate
Diseases
Cervical cancer
GWAS
Abdominal aortic aneurysm (
32981348
)
Alanine aminotransferase levels (
34315874
33547301
)
Aspartate aminotransferase levels (
34315874
33547301
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
30529582
31826910
22634755
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Dilated cardiomyopathy (MTAG) (
33495596
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
20062063
)
Electrocardiographic traits (multivariate) (
32602732
)
Glaucoma (primary open-angle) (
29891935
)
Heart failure (
31919418
)
Hypertrophic cardiomyopathy (
33495597
33495596
)
Hypertrophic cardiomyopathy (MTAG) (
33495596
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
JT interval (
29874175
)
Left ventricle wall thickness (
33495596
)
Left ventricular fractional shortening (
28394258
)
Left ventricular global circumferential strain (
33495596
)
Left ventricular global radial strain (
33495596
)
Left ventricular mass to end-diastolic volume ratio (
33495596
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
QRS complex (Cornell) (
27659466
)
QRS duration (
31251759
31217584
30679814
27659466
27577874
25035420
21076409
)
Triglyceride levels (
32203549
)
Triglycerides (
27036123
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Leukocyte telomere length (
32109421
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
27863252
28957414
32888494
)
Interacting Genes
207 interacting genes:
A1BG
A2M
ABL1
ACTB
ACTL6B
ADAMTS10
AKT1
AKT2
ALAS1
ANGPT2
APLP1
APP
ATP5F1B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
CASP3
CCDC85B
CCN3
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHEK2
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
CZIB
DAPK3
DCAF11
DDAH2
DEAF1
DOCK7
DTL
DYNC1I1
EEF1A1
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FHL3
FLAD1
FNDC11
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB5
GOLGA2
H1-5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HMGXB3
HNRNPK
HOOK2
HOXD8
HPD
IKBKG
IKZF3
INCA1
ING5
INPP5K
KIFC3
KLHL23
KMT2B
KRT31
KRTAP3-1
LATS2
LRIF1
LRP2BP
LRR1
LZTS2
MAP3K5
MAPK8
MCM10
MED31
MEOX2
MSH2
MTUS2
NFYA
NGFR
NKD2
NMRK2
NPRL2
NR1H2
NRBP1
NSUN2
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
POLD2
PPM1D
PRKACA
PRKAR1B
PRKN
PSMA3
PSMC2
QARS1
RAB1A
RACK1
RAI1
RANBP9
RB1
RBBP4
RBM48
REL
RNF144B
RPL18
RPL35
RPS2
RRM2B
S100A8
SCML2
SDF4
SET
SETDB1
SHISA6
SIPA1
SKP1
SLC25A11
SP110
SPRED1
STAT3
STAT5B
STUB1
SUMO3
TAF5L
TCF4
TEX11
TFIP11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TNKS
TRAF1
TRIM21
TRIM3
TRIM54
TRIM71
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBE2D1
UNC119
USHBP1
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
166 interacting genes:
A1BG
A2M
AAMP
ABHD4
ACTB
ACTL6B
ACTR1B
ADAMTS10
ADD1
AGAP1
ALAS1
ALB
APLP1
APP
ARFGAP1
ATG16L2
ATP5F1B
ATP6V1A
ATXN3
BAG6
BOLA2
BOLA2B
CARHSP1
CCDC90B
CDC20
CDK1
CDK4
CDKN1A
CENPB
CFTR
CHGB
CLEC3B
COL11A2
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CRMP1
CSAD
DACT1
DALRD3
DCAF13
DDAH2
DEAF1
DMPK
DOCK7
DRAP1
DUS2
DYNC1I1
DYNC2I1
DYNLT2B
EEF1A1
EIF3G
EIF4A2
EIF6
ERG28
EXT2
EZH2
F13A1
FAF1
FAM20C
FBN3
FGB
FLAD1
FST
FZR1
GAPDH
GDF9
GDI1
GET3
GLB1
GPCPD1
HADHB
HERC3
HMGXB3
HSPBAP1
IER3IP1
IGHM
IMMT
INPP5K
INTS11
ITSN1
JADE1
JMJD1C
KDM6B
KIF21B
KIF5A
KLHL23
KLHL5
KMT2B
LRIF1
MAGEA4
MAST2
MED31
METTL23
MKI67
MPP1
MPPED1
MRFAP1
MRPL20-AS1
MRPL37
MSH2
NEUROD2
NGFR
NKIRAS2
NMT2
NRBP1
ODC1
PAAF1
PDE4DIP
PJA1
PKM
PLD3
PLXNA3
PPP4C
PRMT1
PROC
PSME1
PTPN4
PTPRK
QARS1
RBBP4
RBM48
REX1BD
RPA1
RPL13
RPS2
RUVBL1
RXRA
SDF4
SEMA5B
SEPTIN6
SETDB1
SEZ6L2
SMC5
SNX1
SP110
SULT1A3
SUMO2
SUMO3
TAF1C
THOC3
TIAM2
TLE1
TMSB4X
TP53
TRIM46
TRMT2A
TSC2
TTC38
TUBA1A
TUBB2A
TUBB3
TYK2
UBC
UNC119
UPF2
USP4
VMA22
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZXDC
Entrez ID
1026
7083
HPRD ID
00298
01771
Ensembl ID
ENSG00000124762
ENSG00000167900
Uniprot IDs
P38936
A0A384MDV9
K7ERV3
K7ES52
P04183
PDB IDs
1AXC
2ZVV
2ZVW
4RJF
5E0U
6CBI
6CEJ
6CIV
6CIX
6P8H
7KQ0
7KQ1
8GJF
1W4R
1XBT
2ORV
2WVJ
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Regulation Of Primary Metabolic Process
Cytoplasm
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle
Cyclin-dependent Protein Kinase Holoenzyme Complex
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Cyclin Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Cytosol
Regulation Of Programmed Cell Death
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Macromolecule Metabolic Process
Regulation Of Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Signal Transduction
Cellular Response To Stress
Negative Regulation Of Intracellular Signal Transduction
Protein Binding
Regulation Of Macromolecule Biosynthetic Process
Protein Kinase Binding
Regulation Of DNA-templated Transcription
Negative Regulation Of Cell Cycle
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
DNA Damage Response
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Cell Cycle
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Fibroblast Proliferation
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Cytoplasm
Macromolecule Metabolic Process
Protein Metabolic Process
Platelet Alpha Granule Lumen
Chromatin Organization
Blood Microparticle
Negative Regulation Of Cell Cycle G1/S Phase Transition
Chromatin Remodeling
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Extracellular Exosome
Cytosol
Regulation Of DNA Replication
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein Binding
Nucleoplasm
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Transferase Activity
Nuclear Matrix
Regulation Of Protein Catabolic Process
DNA Synthesis Involved In Mitotic DNA Replication
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Macromolecule Biosynthetic Process
Chromosome, Telomeric Region
Positive Regulation Of Protein Metabolic Process
Cytoskeleton
Negative Regulation Of Cell Cycle Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein Tag Activity
Developmental Process
Growth Cone
Protein Modification Process
Cellular Response To Norepinephrine Stimulus
Response To Norepinephrine
Mitotic DNA Damage Checkpoint Signaling
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Oocyte Growth
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?