CDKN1A and GCKR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDKN1A	GCKR
Gene Name		cyclin-dependent kinase inhibitor 1A (p21, Cip1)	glucokinase (hexokinase 4) regulator
Image
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm PCNA-p21 Complex	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin-dependent Protein Kinase Activating Kinase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Metal Ion Binding	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Carbohydrate Binding Fructose-6-phosphate Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Response To X-ray Response To Organonitrogen Compound Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Organ Regeneration Cellular Response To Extracellular Stimulus Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Phosphorylation Response To Drug Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Arsenic-containing Substance Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Response To Corticosterone Response To Hyperoxia Intestinal Epithelial Cell Maturation Cellular Response To Ionizing Radiation Cellular Response To UV-B Mitotic Cell Cycle Arrest Cellular Senescence Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Protein Import Into Nucleus, Translocation Cellular Glucose Homeostasis Carbohydrate Metabolic Process Hexose Transport Pathogenesis Response To Fructose Regulation Of Glucose Transport Glucose Transport Negative Regulation Of Glucokinase Activity Positive Regulation Of Glucokinase Activity Small Molecule Metabolic Process Urate Metabolic Process Transmembrane Transport Triglyceride Homeostasis
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Cellular Senescence p53-Dependent G1/S DNA damage checkpoint Cyclin E associated events during G1/S transition AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade G1/S Transition Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Signaling by PDGF DAP12 interactions DNA Damage/Telomere Stress Induced Senescence GAB1 signalosome Senescence-Associated Secretory Phenotype (SASP) S Phase Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR SCF(Skp2)-mediated degradation of p27/p21 Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Adaptive Immune System PIP3 activates AKT signaling Orc1 removal from chromatin p53-Dependent G1 DNA Damage Response PI3K events in ERBB2 signaling Transcriptional activation of p53 responsive genes Downstream signaling of activated FGFR G1/S DNA Damage Checkpoints Innate Immune System Transcriptional activation of cell cycle inhibitor p21 Signalling by NGF Synthesis of DNA G1 Phase Regulation of DNA replication Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Cell Cycle, Mitotic Signaling by FGFR Orc1 removal from chromatin Cyclin D associated events in G1 Cell Cycle Checkpoints	Myoclonic epilepsy of Lafora Glycogen storage diseases Regulation of Glucokinase by Glucokinase Regulatory Protein Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport
Drugs
Diseases
GWAS		Colorectal cancer ( 22634755) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Ventricular conduction ( 21076409)	Breast size ( 22747683) C-reactive protein ( 18439548 21300955) Calcium levels ( 20705733) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 20686565) Chronic kidney disease ( 20383146) Crohn's disease ( 21102463) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting insulin-related traits ( 20081858) Fasting insulin-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 22508271) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323 20657596) LDL cholesterol ( 18179892) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910 21886157) Metabolite levels ( 21909109 22286219 22916037) Non-albumin protein levels ( 22558069) Palmitic acid (16:0) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 21829377 22359512) Platelet counts ( 22139419) Serum albumin level ( 23022100) Serum total protein level ( 23022100) Sex hormone-binding globulin levels ( 22829776) Triglycerides ( 23726366 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Two-hour glucose challenge ( 20081857) Urate levels ( 20884846 20139978 23263486) Uric acid levels ( 19503597) Waist Circumference - Triglycerides (WC-TG) ( 21386085) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		176 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AKT1 ALAS1 ANGPT2 APLP1 APP ATP5B ATP6V1A ATXN3 BAD BAG6 BCCIP C1orf123 CASP3 CCDC85B CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC42 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB DAPK3 DDAH2 DEAF1 DOCK7 DYNC1I1 EEF1A1 EP300 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB2L1 GNB5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HIST1H1B HMGXB3 HNRNPK HOXD8 HPD IKBKG IKZF3 ING5 INPP5K KLHL23 KMT2B KRT31 LATS2 LRIF1 MAP3K5 MAPK8 MCM10 MED31 MSH2 NGFR NKD2 NMRK2 NOV NPM1 NPRL2 NR1H2 NRBP1 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 PKM POLD2 PSMA3 QARS RAB1A RAI1 RB1 RBBP4 RBM48 RNF126 RNF144B RPL18 RPL35 RPS2 S100A8 SDF4 SET SETDB1 SIPA1 SKP2 SLC25A11 SP110 SPRED1 STAT3 SUMO3 TAF5L TCF4 TEX11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TRAF1 TRIM54 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBC UBE2D1 UNC119 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431	3 interactors: CDKN1A GCK TRAF2
Entrez ID		1026	2646
HPRD ID		00298	02909
Ensembl ID		ENSG00000124762	ENSG00000084734
Uniprot IDs		J3KQV0 P38936	F5H1P6 Q14397
PDB IDs		1AXC 2ZVV 2ZVW	4BB9 4BBA
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Cell Cycle Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Regulation Of Phosphorylation Nitrogen Compound Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Cell Death Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Division Regulation Of Protein Phosphorylation Organelle Organization Regulation Of Cellular Process Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Chromosome Organization Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Macromolecule Biosynthetic Process Biosynthetic Process Apoptotic Process Cell Death Death Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Response To Stress Cellular Response To Stimulus	Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Localization Innate Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cellular Protein Metabolic Process Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Regulation Of Stress-activated MAPK Cascade Defense Response Positive Regulation Of MAP Kinase Activity Cellular Response To Extracellular Stimulus Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Detection Of Glucose Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Cell Activation Intracellular Signal Transduction Cellular Response To Organic Substance Intestinal Epithelial Cell Maturation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Epinephrine Secretion Immune System Process Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Lymphocyte Activation Regulation Of Protein Secretion Regulation Of Protein Metabolic Process Cellular Response To UV-B Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Response To Extracellular Stimulus
Tagcloud ?		antigen arf cd24 competitively context e6 glioma hairpin inactivation mdm2 mutated mutates nearly npm oncogenes overexpressed p21 papilloma prevents prostate retard reveal shrna silencing silico somatic sv40 tp53 viral	aetiology ancestry college direction equivocal european europeans genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 slc22a11 urate zealand
Tagcloud (Difference) ?		antigen arf cd24 competitively context e6 glioma hairpin inactivation mdm2 mutated mutates nearly npm oncogenes overexpressed p21 papilloma prevents prostate retard reveal shrna silencing silico somatic sv40 tp53 viral	aetiology ancestry college direction equivocal european europeans genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 slc22a11 urate zealand
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