CDKN1A and TCF4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CDKN1A	TCF4
Gene Name		cyclin-dependent kinase inhibitor 1A (p21, Cip1)	transcription factor 4
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Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm PCNA-p21 Complex	Nucleus Transcription Factor Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin-dependent Protein Kinase Activating Kinase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase Recruiting Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription TFIIB-class Binding Transcription Factor Activity TFIIB-class Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Response To X-ray Response To Organonitrogen Compound Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Organ Regeneration Cellular Response To Extracellular Stimulus Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Phosphorylation Response To Drug Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Arsenic-containing Substance Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Response To Corticosterone Response To Hyperoxia Intestinal Epithelial Cell Maturation Cellular Response To Ionizing Radiation Cellular Response To UV-B Mitotic Cell Cycle Arrest Cellular Senescence Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein-DNA Complex Assembly
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Cellular Senescence p53-Dependent G1/S DNA damage checkpoint Cyclin E associated events during G1/S transition AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade G1/S Transition Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Signaling by PDGF DAP12 interactions DNA Damage/Telomere Stress Induced Senescence GAB1 signalosome Senescence-Associated Secretory Phenotype (SASP) S Phase Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR SCF(Skp2)-mediated degradation of p27/p21 Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Adaptive Immune System PIP3 activates AKT signaling Orc1 removal from chromatin p53-Dependent G1 DNA Damage Response PI3K events in ERBB2 signaling Transcriptional activation of p53 responsive genes Downstream signaling of activated FGFR G1/S DNA Damage Checkpoints Innate Immune System Transcriptional activation of cell cycle inhibitor p21 Signalling by NGF Synthesis of DNA G1 Phase Regulation of DNA replication Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Cell Cycle, Mitotic Signaling by FGFR Orc1 removal from chromatin Cyclin D associated events in G1 Cell Cycle Checkpoints	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS		Colorectal cancer ( 22634755) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Ventricular conduction ( 21076409)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Diabetic retinopathy ( 21441570) Fuchs's corneal dystrophy ( 20825314) Obesity (early onset extreme) ( 23563609) Schizophrenia ( 21926974 19571808 19571811 22688191 23894747) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403)
Protein-Protein Interactions		176 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AKT1 ALAS1 ANGPT2 APLP1 APP ATP5B ATP6V1A ATXN3 BAD BAG6 BCCIP C1orf123 CASP3 CCDC85B CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC42 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB DAPK3 DDAH2 DEAF1 DOCK7 DYNC1I1 EEF1A1 EP300 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB2L1 GNB5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HIST1H1B HMGXB3 HNRNPK HOXD8 HPD IKBKG IKZF3 ING5 INPP5K KLHL23 KMT2B KRT31 LATS2 LRIF1 MAP3K5 MAPK8 MCM10 MED31 MSH2 NGFR NKD2 NMRK2 NOV NPM1 NPRL2 NR1H2 NRBP1 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 PKM POLD2 PSMA3 QARS RAB1A RAI1 RB1 RBBP4 RBM48 RNF126 RNF144B RPL18 RPL35 RPS2 S100A8 SDF4 SET SETDB1 SIPA1 SKP2 SLC25A11 SP110 SPRED1 STAT3 SUMO3 TAF5L TCF4 TEX11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TRAF1 TRIM54 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBC UBE2D1 UNC119 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431	173 interactors: AES AQP1 AR ARHGEF1 ARMC7 ASCL1 ASCL3 ASCL4 ASPSCR1 ATP6V1B2 BCAS2 BCL2L2 BZRAP1 C19orf66 C1orf109 C9orf171 CABP5 CALM1 CALM2 CALM3 CCDC101 CDC73 CDKN1A CDKN2C CHAF1A CHCHD2 CHIC2 CKS1B CTBP1 CTNNB1 DDX6 DEF6 DGCR6 DMRT3 EFHC1 EIF4E2 EIF4EBP1 EP300 EPB41L3 EPHB6 EXOSC1 FAH FAM124B FAM74A4 FERD3L FLAD1 FLNA FRS3 GEM GLRX3 GNG10 GOLGA8EP GOLGA8F GORASP2 GTF3C5 GUCD1 HAND2 HAT1 HBP1 HIC1 HSPB7 ID1 ID2 ID3 ID4 INS JUN JUP KCTD14 KLC3 KLHL32 LASP1 LENG1 LGALS14 LMO1 LMO4 LNPEP LYL1 MAD2L2 MAGOHB MAPKBP1 MATN3 MEMO1 MEN1 MLLT6 MORN4 MRFAP1L1 MRPL10 MSC MSRB3 MVP MYO5B MYOD1 NCK2 NDOR1 NEK6 NEK8 NEU4 NEUROD1 NEUROG1 NME7 NMUR2 NOL9 NR2C2AP NR4A1 NUDT10 ORC4 OSGIN1 OTUD4 PARK2 PARP1 PATE1 PBLD PIN1 PLEKHN1 POLR1A POLR1C PPIA PPIL1 PPP1R18 PRKAA2 PRKAB2 PSEN1 PSMA1 PSMG2 PTF1A PTGER3 RAB41 RABIF RECK RELA REXO1L6P RNF138 RSPH14 RUNX1T1 SCOC SEC14L4 SIGLEC6 SLC39A13 SLC4A1AP SMCP SMOC1 SPATC1L SPG21 SRSF2 STAMBPL1 STK16 STX11 SUMO1 SZT2 TAL1 TAL2 TAPBPL TCEA2 TCF3 TCL1A TLE1 TMEM213 TRAPPC2L TSSC4 TSSK3 TWIST2 TXNL4B USP4 UTP23 VPS28 XRCC5 XRCC6 ZDHHC24 ZNF124 ZNF205-AS1 ZNF417 ZNF587
Entrez ID		1026	6925
HPRD ID		00298	03780
Ensembl ID		ENSG00000124762	ENSG00000196628
Uniprot IDs		J3KQV0 P38936	B3KVA4 E9PH57 H3BTP3 P15884
PDB IDs		1AXC 2ZVV 2ZVW	2KWF
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Cell Cycle Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Regulation Of Phosphorylation Nitrogen Compound Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Cell Death Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Division Regulation Of Protein Phosphorylation Organelle Organization Regulation Of Cellular Process Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Chromosome Organization Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Macromolecule Biosynthetic Process Biosynthetic Process Apoptotic Process Cell Death Death Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Response To Stress Cellular Response To Stimulus	Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Binding Negative Regulation Of Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Negative Regulation Of Cellular Protein Metabolic Process Organ Development Regulation Of Metabolic Process Regulation Of Binding System Development Regulation Of Nitrogen Compound Metabolic Process Developmental Process Regulation Of Gene Expression Central Nervous System Development Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Binding Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Cell Fate Commitment Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		antigen arf cd24 competitively context e6 glioma hairpin inactivation mdm2 mutated mutates nearly npm oncogenes overexpressed p21 papilloma prevents prostate retard reveal shrna silencing silico somatic sv40 tp53 viral	action activities agent beta biejiajian catenin cultured cyclin cytoplasmic d1 downstream expressions fed hepatocellular hepg2 immunofluorescence inhibiting invasiveness lowered luciferase mmp pills qrt sera serve suppress underlying whose wnt
Tagcloud (Difference) ?		antigen arf cd24 competitively context e6 glioma hairpin inactivation mdm2 mutated mutates nearly npm oncogenes overexpressed p21 papilloma prevents prostate retard reveal shrna silencing silico somatic sv40 tp53 viral	action activities agent beta biejiajian catenin cultured cyclin cytoplasmic d1 downstream expressions fed hepatocellular hepg2 immunofluorescence inhibiting invasiveness lowered luciferase mmp pills qrt sera serve suppress underlying whose wnt
Tagcloud (Intersection) ?