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CDKN1A and CDK1
Number of citations of the paper that reports this interaction (PubMedID
32707033
)
104
Data Source:
BioGRID
(affinity chromatography technology, biochemical, affinity chromatography technology)
HPRD
(in vivo)
CDKN1A
CDK1
Description
cyclin dependent kinase inhibitor 1A
cyclin dependent kinase 1
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Body
Protein-containing Complex
PCNA-p21 Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Spindle
Cytosol
Cytoskeleton
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin A1-CDK1 Complex
Cyclin A2-CDK1 Complex
Cyclin B1-CDK1 Complex
Molecular Function
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Serine/threonine Kinase Binding
Protein Sequestering Activity
Molecular Function Activator Activity
Molecular Function Inhibitor Activity
Nucleotide Binding
Virus Receptor Activity
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Transferase Activity
Cyclin Binding
Hsp70 Protein Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
Protein Serine Kinase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
In Utero Embryonic Development
Protein Import Into Nucleus
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Epidermis Development
Response To UV
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of B Cell Proliferation
Mitotic G1 DNA Damage Checkpoint Signaling
Cellular Response To Amino Acid Starvation
Wound Healing
Tissue Regeneration
Signal Transduction In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Programmed Cell Death
Keratinocyte Proliferation
Positive Regulation Of DNA Replication
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Growth
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Import Into Nucleus
Regulation Of Cell Cycle
Cellular Response To Cell-matrix Adhesion
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-B
Signal Transduction By P53 Class Mediator
Cellular Senescence
Replicative Senescence
Stress-induced Premature Senescence
Oncogene-induced Cell Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of DNA Biosynthetic Process
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Nuclear Envelope Organization
Mitotic Nuclear Membrane Disassembly
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Pronuclear Fusion
Response To Toxic Substance
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Response To Amine
Response To Activity
Cell Migration
Protein Deubiquitination
Peptidyl-threonine Phosphorylation
Chromosome Condensation
Epithelial Cell Differentiation
Protein Localization To Kinetochore
Positive Regulation Of Protein Import Into Nucleus
Response To Hydrogen Peroxide
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Mitotic Cell Cycle Phase Transition
Response To Ethanol
Positive Regulation Of DNA Replication
Regulation Of Embryonic Development
Thymidine Biosynthetic Process
Response To Cadmium Ion
Response To Copper Ion
Symbiont Entry Into Host Cell
Microtubule Polymerization
Fibroblast Proliferation
Rhythmic Process
Response To Axon Injury
Cell Division
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Cilium Disassembly
Positive Regulation Of Mitotic Sister Chromatid Segregation
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
ERK1 And ERK2 Cascade
Golgi Disassembly
DNA Strand Resection Involved In Replication Fork Processing
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Microtubule Cytoskeleton Organization Involved In Mitosis
DNA Synthesis Involved In Mitotic DNA Replication
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Protein Localization To Site Of Double-strand Break
Mitotic DNA-templated DNA Replication
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Transcriptional regulation by RUNX2
RUNX3 regulates CDKN1A transcription
Neddylation
Transcriptional regulation of granulopoiesis
FOXO-mediated transcription of cell cycle genes
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerization of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
PKR-mediated signaling
Drugs
Valproic acid
Arsenic trioxide
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
Seliciclib
AT-7519
Fostamatinib
Avotaciclib
Diseases
Cervical cancer
GWAS
Abdominal aortic aneurysm (
32981348
)
Alanine aminotransferase levels (
34315874
33547301
)
Aspartate aminotransferase levels (
34315874
33547301
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
30529582
31826910
22634755
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Dilated cardiomyopathy (MTAG) (
33495596
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
20062063
)
Electrocardiographic traits (multivariate) (
32602732
)
Glaucoma (primary open-angle) (
29891935
)
Heart failure (
31919418
)
Hypertrophic cardiomyopathy (
33495597
33495596
)
Hypertrophic cardiomyopathy (MTAG) (
33495596
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
JT interval (
29874175
)
Left ventricle wall thickness (
33495596
)
Left ventricular fractional shortening (
28394258
)
Left ventricular global circumferential strain (
33495596
)
Left ventricular global radial strain (
33495596
)
Left ventricular mass to end-diastolic volume ratio (
33495596
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
QRS complex (Cornell) (
27659466
)
QRS duration (
31251759
31217584
30679814
27659466
27577874
25035420
21076409
)
Triglyceride levels (
32203549
)
Triglycerides (
27036123
)
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Interacting Genes
207 interacting genes:
A1BG
A2M
ABL1
ACTB
ACTL6B
ADAMTS10
AKT1
AKT2
ALAS1
ANGPT2
APLP1
APP
ATP5F1B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
CASP3
CCDC85B
CCN3
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHEK2
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
CZIB
DAPK3
DCAF11
DDAH2
DEAF1
DOCK7
DTL
DYNC1I1
EEF1A1
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FHL3
FLAD1
FNDC11
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB5
GOLGA2
H1-5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HMGXB3
HNRNPK
HOOK2
HOXD8
HPD
IKBKG
IKZF3
INCA1
ING5
INPP5K
KIFC3
KLHL23
KMT2B
KRT31
KRTAP3-1
LATS2
LRIF1
LRP2BP
LRR1
LZTS2
MAP3K5
MAPK8
MCM10
MED31
MEOX2
MSH2
MTUS2
NFYA
NGFR
NKD2
NMRK2
NPRL2
NR1H2
NRBP1
NSUN2
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
POLD2
PPM1D
PRKACA
PRKAR1B
PRKN
PSMA3
PSMC2
QARS1
RAB1A
RACK1
RAI1
RANBP9
RB1
RBBP4
RBM48
REL
RNF144B
RPL18
RPL35
RPS2
RRM2B
S100A8
SCML2
SDF4
SET
SETDB1
SHISA6
SIPA1
SKP1
SLC25A11
SP110
SPRED1
STAT3
STAT5B
STUB1
SUMO3
TAF5L
TCF4
TEX11
TFIP11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TNKS
TRAF1
TRIM21
TRIM3
TRIM54
TRIM71
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBE2D1
UNC119
USHBP1
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
241 interacting genes:
ABL1
ACSL4
ADD1
AKAP12
AKT1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BCL2L11
BIRC5
BIRC6
BRCA1
BRCA2
BTG2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDCA2
CDCA5
CDK7
CDKN1A
CDKN3
CDT1
CEBPA
CENPF
CEP55
CEP63
CHAF1B
CIITA
CIP2A
CKS2
CNOT7
CREB1
CREM
CSN2
CSNK2A1
CSNK2B
CTNNB1
CUL4B
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EML3
EPN1
ERCC2
ERCC6L
FANCA
FANCC
FANCG
FBXO5
FEN1
FLNA
FOXM1
FOXO1
FYN
GADD45A
GADD45B
GADD45G
GAS2L3
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HASPIN
HJURP
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
ID2
IDH1
IDH2
IL16
IL3RA
IQGAP1
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LRRK1
LYN
LZTS1
MAP4
MAPK12
MAPT
MBP
MCM2
MCM4
MDM4
MEF2C
MIS18BP1
MISP
MKI67
MLKL
MLST8
MNDA
MYC
MYT1
NCAPD2
NCAPD3
NCAPG
NCAPH
NCL
NDE1
NEDD1
NES
NHERF1
NONO
NPM1
NSFL1C
NUP210
PAK6
PBK
PCM1
PCNA
PIN1
PIP5K1C
PITPNM1
PKMYT1
PLEC
PML
POLA1
POLL
PON1
PPP1R12A
PPP2R1A
PPP2R1B
PPP2R2B
PPP4R2
PPP4R3A
PRC1
PRDX1
PRDX2
PRKAR2A
PSRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAD9A
RANGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RGCC
RPA2
RPS3
RPS6KB1
RRM2
RSF1
RUNX1
RUNX2
SAMHD1
SFN
SLBP
SOX2
SP1
SPAG5
SQSTM1
SRC
SSBP1
STK3
STMN1
STMN2
TERF1
TFDP1
TGFBR2
TK1
TLE1
TMPO
TNNC1
TOP2A
TP53
TP53BP1
TP73
TPR
TSC1
TSPYL2
TUBB
UBA1
UBE2A
UBE3A
UHRF2
USP14
USP16
VHL
VIM
WAC
WEE1
XIAP
XPO1
XRCC6
ZBTB16
Entrez ID
1026
983
HPRD ID
00298
00302
Ensembl ID
ENSG00000124762
ENSG00000170312
Uniprot IDs
P38936
B7Z3D6
I6L9I5
P06493
PDB IDs
1AXC
2ZVV
2ZVW
4RJF
5E0U
6CBI
6CEJ
6CIV
6CIX
6P8H
7KQ0
7KQ1
8GJF
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
6TWN
7NJ0
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Regulation Of Primary Metabolic Process
Cytoplasm
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle
Cyclin-dependent Protein Kinase Holoenzyme Complex
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Cyclin Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Cytosol
Regulation Of Programmed Cell Death
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Macromolecule Metabolic Process
Regulation Of Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Signal Transduction
Cellular Response To Stress
Negative Regulation Of Intracellular Signal Transduction
Protein Binding
Regulation Of Macromolecule Biosynthetic Process
Protein Kinase Binding
Regulation Of DNA-templated Transcription
Negative Regulation Of Cell Cycle
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
DNA Damage Response
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Cell Cycle
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Fibroblast Proliferation
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Cell Cycle
Regulation Of Cell Cycle Process
Cell Division
Nucleus
Cellular Response To Stress
Nucleoplasm
DNA Damage Response
Regulation Of Mitotic Cell Cycle
Organelle Organization
Cytosol
Cytoplasm
Regulation Of Cell Cycle Phase Transition
Chromosome
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Cycle
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Cell Cycle Phase Transition
Intracellular Signal Transduction
Positive Regulation Of Cell Cycle Process
Negative Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Chromosome Organization
DNA Metabolic Process
Response To Stress
Negative Regulation Of Macromolecule Metabolic Process
DNA Repair
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Population Proliferation
Cytoskeleton
Regulation Of DNA Metabolic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Cell Cycle Process
Positive Regulation Of Apoptotic Process
Protein Kinase Binding
Regulation Of Protein Metabolic Process
Regulation Of Cellular Component Organization
Cell Cycle G2/M Phase Transition
Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Binding
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Intracellular Signal Transduction
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Component Assembly
Negative Regulation Of Mitotic Cell Cycle
Tagcloud
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Tagcloud (Intersection)
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