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CDKN1A and ACTL6B
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
CDKN1A
ACTL6B
Gene Name
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
actin-like 6B
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
PCNA-p21 Complex
Nucleus
Nucleolus
SWI/SNF Complex
NBAF Complex
Molecular Function
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Cyclin-dependent Protein Kinase Activating Kinase Activity
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein Complex Binding
Metal Ion Binding
Transcription Coactivator Activity
Structural Constituent Of Cytoskeleton
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Response To X-ray
Response To Organonitrogen Compound
Negative Regulation Of Gene Expression
Negative Regulation Of Cell Growth
Positive Regulation Of B Cell Proliferation
Organ Regeneration
Cellular Response To Extracellular Stimulus
Regulation Of Protein Import Into Nucleus, Translocation
Cellular Response To Heat
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Phosphorylation
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Innate Immune Response
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Response To Arsenic-containing Substance
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Response To Corticosterone
Response To Hyperoxia
Intestinal Epithelial Cell Maturation
Cellular Response To Ionizing Radiation
Cellular Response To UV-B
Mitotic Cell Cycle Arrest
Cellular Senescence
Stress-induced Premature Senescence
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Chromatin Organization
Chromatin Remodeling
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Nervous System Development
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
Cellular Senescence
p53-Dependent G1/S DNA damage checkpoint
Cyclin E associated events during G1/S transition
AKT phosphorylates targets in the cytosol
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
PI-3K cascade
G1/S Transition
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Signaling by PDGF
DAP12 interactions
DNA Damage/Telomere Stress Induced Senescence
GAB1 signalosome
Senescence-Associated Secretory Phenotype (SASP)
S Phase
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
SCF(Skp2)-mediated degradation of p27/p21
Downstream signal transduction
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
PI3K/AKT Signaling in Cancer
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Adaptive Immune System
PIP3 activates AKT signaling
Orc1 removal from chromatin
p53-Dependent G1 DNA Damage Response
PI3K events in ERBB2 signaling
Transcriptional activation of p53 responsive genes
Downstream signaling of activated FGFR
G1/S DNA Damage Checkpoints
Innate Immune System
Transcriptional activation of cell cycle inhibitor p21
Signalling by NGF
Synthesis of DNA
G1 Phase
Regulation of DNA replication
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Cell Cycle, Mitotic
Signaling by FGFR
Orc1 removal from chromatin
Cyclin D associated events in G1
Cell Cycle Checkpoints
Chromatin modifying enzymes
Chromatin organization
RMTs methylate histone arginines
Drugs
Diseases
GWAS
Colorectal cancer (
22634755
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
20062063
)
Ventricular conduction (
21076409
)
Red blood cell traits (
23222517
)
Protein-Protein Interactions
176 interactors:
A1BG
A2M
ACTB
ACTL6B
ADAMTS10
AKT1
ALAS1
ANGPT2
APLP1
APP
ATP5B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
C1orf123
CASP3
CCDC85B
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC42
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
DAPK3
DDAH2
DEAF1
DOCK7
DYNC1I1
EEF1A1
EP300
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FLAD1
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB2L1
GNB5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HIST1H1B
HMGXB3
HNRNPK
HOXD8
HPD
IKBKG
IKZF3
ING5
INPP5K
KLHL23
KMT2B
KRT31
LATS2
LRIF1
MAP3K5
MAPK8
MCM10
MED31
MSH2
NGFR
NKD2
NMRK2
NOV
NPM1
NPRL2
NR1H2
NRBP1
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
PKM
POLD2
PSMA3
QARS
RAB1A
RAI1
RB1
RBBP4
RBM48
RNF126
RNF144B
RPL18
RPL35
RPS2
S100A8
SDF4
SET
SETDB1
SIPA1
SKP2
SLC25A11
SP110
SPRED1
STAT3
SUMO3
TAF5L
TCF4
TEX11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TRAF1
TRIM54
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBC
UBE2D1
UNC119
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
11 interactors:
ANXA7
APP
CDKN1A
COQ9
CSNK2B
CTBP1
GSK3B
PLK1
SMARCA2
SMN1
TK1
Entrez ID
1026
51412
HPRD ID
00298
12419
Ensembl ID
ENSG00000124762
ENSG00000077080
Uniprot IDs
J3KQV0
P38936
O94805
PDB IDs
1AXC
2ZVV
2ZVW
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Cycle
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cell Cycle
Mitotic Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Kinase Activity
Cell Cycle Process
Regulation Of Protein Kinase Activity
Mitotic Cell Cycle Process
Negative Regulation Of Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
Cellular Aromatic Compound Metabolic Process
Regulation Of Phosphorylation
Nitrogen Compound Metabolic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Regulation Of Cell Death
Regulation Of Catalytic Activity
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cell Division
Regulation Of Protein Phosphorylation
Organelle Organization
Regulation Of Cellular Process
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Chromosome Organization
Negative Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Protein Metabolic Process
Programmed Cell Death
Macromolecule Biosynthetic Process
Biosynthetic Process
Apoptotic Process
Cell Death
Death
Positive Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Response To Stress
Cellular Response To Stimulus
Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Binding
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Protein Metabolic Process
Protein Phosphorylation
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Negative Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Modification Process
Regulation Of Protein Binding
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Ketone Metabolic Process
Response To Toxic Substance
Developmental Process
Regulation Of Protein Phosphorylation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Cellular Metabolic Process
Regulation Of Cellular Component Organization
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Kinase Activity
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Growth
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Kinase Activity
Negative Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Negative Regulation Of Cell Proliferation
Negative Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Phosphorylation
Cell Differentiation
Positive Regulation Of Metabolic Process
Positive Regulation Of Cell Cycle
Anatomical Structure Development
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Proteolysis
Negative Regulation Of Transferase Activity
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Catalytic Activity
Positive Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Protein Phosphorylation
Response To Metal Ion
Cellular Response To Heat
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud
?
antigen
arf
cd24
competitively
context
e6
glioma
hairpin
inactivation
mdm2
mutated
mutates
nearly
npm
oncogenes
overexpressed
p21
papilloma
prevents
prostate
retard
reveal
shrna
silencing
silico
somatic
sv40
tp53
viral
Tagcloud (Difference)
?
antigen
arf
cd24
competitively
context
e6
glioma
hairpin
inactivation
mdm2
mutated
mutates
nearly
npm
oncogenes
overexpressed
p21
papilloma
prevents
prostate
retard
reveal
shrna
silencing
silico
somatic
sv40
tp53
viral
Tagcloud (Intersection)
?