CDKN1A and USHBP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDKN1A	USHBP1
Description		cyclin dependent kinase inhibitor 1A	USH1 protein network component harmonin binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Body Protein-containing Complex PCNA-p21 Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding Protein Serine/threonine Kinase Binding Protein Sequestering Activity Molecular Function Activator Activity Molecular Function Inhibitor Activity	Protein Binding PDZ Domain Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Protein Import Into Nucleus DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Response To UV Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Keratinocyte Differentiation Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of B Cell Proliferation Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To Amino Acid Starvation Wound Healing Tissue Regeneration Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Programmed Cell Death Keratinocyte Proliferation Positive Regulation Of DNA Replication Positive Regulation Of Protein Kinase Activity Negative Regulation Of Growth Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Import Into Nucleus Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Signal Transduction By P53 Class Mediator Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Oncogene-induced Cell Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Neddylation Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs		Valproic acid Arsenic trioxide
Diseases		Cervical cancer
GWAS		Abdominal aortic aneurysm ( 32981348) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874 33547301) Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 30529582 31826910 22634755) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) JT interval ( 29874175) Left ventricle wall thickness ( 33495596) Left ventricular fractional shortening ( 28394258) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 31251759 31217584 30679814 27659466 27577874 25035420 21076409) Triglyceride levels ( 32203549) Triglycerides ( 27036123)	Mitochondrial DNA copy number ( 30704525)
Interacting Genes		207 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 FNDC11 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 GOLGA2 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOOK2 HOXD8 HPD IKBKG IKZF3 INCA1 ING5 INPP5K KIFC3 KLHL23 KMT2B KRT31 KRTAP3-1 LATS2 LRIF1 LRP2BP LRR1 LZTS2 MAP3K5 MAPK8 MCM10 MED31 MEOX2 MSH2 MTUS2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 NSUN2 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 POLD2 PPM1D PRKACA PRKAR1B PRKN PSMA3 PSMC2 QARS1 RAB1A RACK1 RAI1 RANBP9 RB1 RBBP4 RBM48 REL RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SCML2 SDF4 SET SETDB1 SHISA6 SIPA1 SKP1 SLC25A11 SP110 SPRED1 STAT3 STAT5B STUB1 SUMO3 TAF5L TCF4 TEX11 TFIP11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TNKS TRAF1 TRIM21 TRIM3 TRIM54 TRIM71 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USHBP1 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431	234 interacting genes: ABHD11 ABI2 ABLIM1 ACMSD AIRIM AKAP9 ANKRD33 ANKRD36BP1 ARFIP2 ARMC5 ARNT2 ASB15 ATP5PO BCAS2 BCL10 BCL2L11 BET1 BEX2 BEX3 BFSP1 BFSP2 BICRAL BLOC1S1 BLZF1 BORCS6 BRAT1 BRPF1 C1orf216 C21orf58 CBY2 CCDC116 CCDC120 CCDC121 CCDC146 CCDC148 CCDC187 CCDC196 CCDC197 CCDC22 CCDC24 CCDC28A CCDC33 CCDC42 CCDC87 CCHCR1 CCNK CDC37 CDC5L CDKN1A CENPP CEP63 CEP68 CFAP206 CHCHD3 CNNM3 COPS4 COPS6 COPS8 CTNNA3 CTNNBIP1 CTTNBP2NL CYTH4 DCTN2 DCTN3 DEPP1 DEUP1 DNAAF19 DRC4 DTNB DYDC1 EIF4E2 ENKD1 ERCC1 EXOC7 EXOC8 FAM107A FAM110A FAM124B FAM161B FANCG FATE1 FBF1 FCHSD2 FCRL5 FTL GATAD2B GCC1 GEM GFI1B GIT2 GMCL2 GNG4 GOLGA6L9 GOLGA8EP GOLGA8F GPSM1 GPSM3 GTF2H1 HAUS1 HAUS8 HGS HMG20A HMG20B HYI IFT20 IL16 IMP3 ING3 INPP1 INTS4 ITGB3BP KANK2 KANSL1 KIAA0753 KLC3 KLC4 KLHL38 KLHL42 KPNA2 KRT14 KRT15 KRT16 KRT19 KRT20 KRT26 KRT27 KRT28 KRT31 KRT37 KRT38 KRT40 KRT71 KRT75 KRT79 LENG1 LINC00526 MAGEB4 MCCD1 MCM7 MCRS1 MED11 MED28 MED4 MEI4 METTL15 MIIP MKRN3 MNS1 MOS MRPS23 MXI1 MYOG MYOZ1 NCAPH2 NDC80 NDE1 NECAB2 NEFL NOC4L NUP62 ODAD3 OIP5 PARVG PAX6 PBX4 PICK1 PKN1 PKNOX2 PMF1 POLM POP5 PPP1R12C PPP1R7 PPP2R5A PPP2R5D PRC1 PRKAA2 PRR5 QARS1 RASAL2 RCOR3 RECK RIBC1 RIBC2 RINT1 RNF20 RTP5 SAPCD2 SAT1 SCNM1 SCT SEC14L4 SEMA4C SERTAD3 SH2D4A SHC3 SMARCD1 SMARCE1 SOHLH1 SPG21 SRI STX11 SYNJ2BP TASOR2 TCEANC TCHP TEKT1 THADA THOC1 TIMM13 TPRX1 TRIM54 TRIML2 TSG101 TTC23 TTC9C TTLL10 TUBGCP4 TXLNA TXLNB UBE2W UBXN11 USH1C USP2 VPS28 ZBTB42 ZFHX3 ZFYVE26 ZNF417 ZNF483 ZNF655 ZNF688 ZNF765 ZNRF2P1
Entrez ID		1026	83878
HPRD ID		00298	18276
Ensembl ID		ENSG00000124762	ENSG00000130307
Uniprot IDs		P38936	B4DUE8 G8JLM4 Q8N6Y0 Q8N8Y1
PDB IDs		1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX 6P8H 7KQ0 7KQ1 8GJF
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Cytoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cyclin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Signal Transduction Cellular Response To Stress Negative Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Fibroblast Proliferation Negative Regulation Of Signaling Negative Regulation Of Cell Communication	Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Keratin Filament Protein Binding Cytoskeleton Organization Intermediate Filament Microtubule-based Process Organelle Organization Structural Molecule Activity Microtubule Cytoskeleton Organization Centrosome Supramolecular Fiber Organization Cytoplasm Structural Constituent Of Cytoskeleton Spindle Pole Establishment Of Spindle Orientation Microtubule Organizing Center Organization Establishment Of Mitotic Spindle Orientation Epithelial Cell Differentiation Establishment Of Spindle Localization Establishment Of Mitotic Spindle Localization Spindle Localization Motile Cilium Organelle Localization Chromosome, Centromeric Region Centriole Kinetochore Microtubule-based Movement Positive Regulation Of Ubiquitin-dependent Endocytosis Morphogenesis Of An Epithelium Microtubule Axonemal A Tubule Inner Sheath Negative Regulation Of Cell Cycle Phase Transition Establishment Of Organelle Localization Membrane Fission Protein Deneddylation CENP-A Containing Chromatin Assembly Ciliary Basal Body Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cis-Golgi Network Centrosome Cycle Regulation Of Post-translational Protein Modification Cilium Movement Centriole Assembly Cilium
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