SPRY2 and DGCR6

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		SPRY2	DGCR6
Gene Name		sprouty homolog 2 (Drosophila)	DiGeorge syndrome critical region gene 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Plasma Membrane Microtubule Cytoskeleton Ruffle Membrane	Proteinaceous Extracellular Matrix Nucleus
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity	Molecular_function
	Biological Process	Establishment Of Mitotic Spindle Orientation Epidermal Growth Factor Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Cell Fate Commitment Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Lung Growth Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity	Cell Adhesion Organ Morphogenesis
Pathways		Signaling by EGFR EGFR downregulation Signaling by FGFR in disease Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Spry regulation of FGF signaling Signaling by FGFR Negative regulation of FGFR signaling
Drugs
Diseases
GWAS		Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) Orofacial clefts ( 20023658 22863734) Type 2 diabetes ( 20862305)
Protein-Protein Interactions		90 interactors: ADAMTSL4 AQP1 ATRIP C19orf66 CATSPER1 CBL CBLB CBLC CHRD CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 EIF4E2 FAIM FAM219A FBN1 FRS3 GNE GP9 GPRIN2 GRAP2 GRB2 HEXIM2 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1B LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 OTX1 PACSIN3 PLSCR1 PRKAB2 PTGER3 PTPN11 RAF1 RTFDC1 RUNX1T1 SDHB SEMA5B SH3KBP1 SIAH2 SPRY1 STK16 TCAF1 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587	61 interactors: ADAMTSL4 AES AGTRAP APP ARNT2 C1orf94 C3orf62 CBLL1 CCDC33 CCDC36 CCDC67 CTAGE5 CTBP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 FBF1 GOLGA2 GSE1 HGS HOMEZ IKZF3 KIAA1377 KLHL12 LZTS2 MBIP MEIS2 MEOX2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NL NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPERT SPRY2 SS18L1 TCF12 TCF4 TFIP11 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446
Entrez ID		10253	8214
HPRD ID		03916	03177
Ensembl ID		ENSG00000136158	ENSG00000183628
Uniprot IDs		O43597	Q14129
PDB IDs		3BUM 3OB1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Keratinization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process Keratinocyte Differentiation Regulation Of Cell Activation Negative Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Cell Death System Development Death Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Developmental Process Multicellular Organismal Development Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of T Cell Activation Cellular Response To Organic Substance Cell Differentiation Anatomical Structure Development Organ Development Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase Activity Epidermal Cell Differentiation Response To Growth Factor Protein Modification By Small Protein Conjugation Epithelium Development Regulation Of Apoptotic Process Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Kinase Activity Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process	RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of ERBB Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Death Developmental Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of ERBB Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Modification By Small Protein Conjugation Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Tagcloud ?		beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger	1rn antidopaminergic daao darpp dgcr2 drd2 drd3 dtnbp1 evolves facets forcefully g72 gabra1 gabra6 gabrp gria1 grin1 grm3 merge mglu2 networking prodh rgs4 slc1a2 slc1a6 underpinned unifying vulnerablility zdhhc8
Tagcloud (Difference) ?		beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger	1rn antidopaminergic daao darpp dgcr2 drd2 drd3 dtnbp1 evolves facets forcefully g72 gabra1 gabra6 gabrp gria1 grin1 grm3 merge mglu2 networking prodh rgs4 slc1a2 slc1a6 underpinned unifying vulnerablility zdhhc8
Tagcloud (Intersection) ?