SPRY2 and SEMA5B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SPRY2	SEMA5B
Description		sprouty RTK signaling antagonist 2	semaphorin 5B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Ruffle Membrane Cell Projection Microtubule End	Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity Ubiquitin-protein Transferase Inhibitor Activity Molecular Function Inhibitor Activity	Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Angiogenesis Lung Development Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Projection Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lung Morphogenesis Lung Growth Bud Elongation Involved In Lung Branching Respiratory System Development ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor	Neural Crest Cell Migration Nervous System Development Axon Guidance Cell Differentiation Positive Regulation Of Cell Migration Axon Extension Detection Of Light Stimulus Involved In Visual Perception Negative Chemotaxis Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Neuron Projection Extension
Pathways		Spry regulation of FGF signaling EGFR downregulation	Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Adiposity ( 21706003) Adventurousness ( 30643258) Body fat percentage ( 26833246) Central corneal thickness ( 32528159) Diastolic blood pressure ( 30224653) Fasting blood insulin (BMI interaction) ( 22581228) General risk tolerance (MTAG) ( 30643258) Height ( 25282103 31562340) Insulin-related traits (multivariate analysis) ( 32002517) Lactose tolerance test ( 31791255) Leisure-time exercise behaviour (age-stratified) ( 30102679) Medication use (drugs used in diabetes) ( 31015401) Methadone dose in opioid dependence ( 28115739) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 20023658 22863734) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Sleep duration ( 25469926) Thrombocytopenia in coronary artery bypass surgery ( 30103242) Type 2 diabetes ( 29358691 30718926 32499647 31118516 30297969 30054458 28869590 26818947 24509480 22885922 20862305) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Cortex volume ( 31530798) Esophageal cancer ( 21642993) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821) Serum albumin levels ( 29403010) Total grey matter volume ( 31530798)
Interacting Genes		110 interacting genes: ADAMTSL4 AQP1 ATRIP BAG3 BRAF CATSPER1 CBL CBLB CBLC CHRD CHRNG CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 DSCR9 DYRK1A EIF4E2 FAIM FAM219A FBN1 FBXO7 FRS3 FXR1 FXR2 GNE GP9 GPRIN2 GRAP2 GRB2 GRN HEXIM2 HNRNPLL HOXA1 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1A LCE1B LCE1C LCE1F LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MB21D2 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 NUFIP2 OTX1 PACSIN3 PLSCR1 PRKAB2 PRKCD PRKD1 PTGER3 PTPN11 RAF1 RTF2 RUNX1T1 SDHB SEMA5B SH3KBP1 SHFL SIAH2 SPRY1 STK16 TCAF1 TMEM14B TNS2 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587	8 interacting genes: ANXA7 C11orf58 FAM118B MRPL44 NUDT21 SMN1 SPRY2 TK1
Entrez ID		10253	54437
HPRD ID		03916	15322
Ensembl ID		ENSG00000136158	ENSG00000082684
Uniprot IDs		O43597	A0A3B3IRP9 A0A3B3IT43 B7Z2B3 C9JKR3 Q9P283
PDB IDs		3BUM 3OB1 5HKY 5HKZ 5HL0
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Phosphotyrosine Residue Binding Identical Protein Binding Epidermis Development Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Binding Cytosol Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Receptor Tyrosine Kinase Binding SH3 Domain Binding Regulation Of Signal Transduction Regulation Of Translation At Presynapse, Modulating Synaptic Transmission ESCRT II Complex ERBB Signaling Pathway Tissue Development Ubiquitin-protein Transferase Activity Regulation Of Cell Activation Regulation Of Biological Quality Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Zinc Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Chromaffin Granule Membrane Cajal Body Nuclear Body DNA Synthesis Involved In Mitotic DNA Replication Thymidine Metabolic Process Protein Tetramerization Thymidine Biosynthetic Process Thymidine Kinase Activity Bud Elongation Involved In Lung Branching Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Ubiquitin-protein Transferase Inhibitor Activity Lung Growth Respiratory System Development Microtubule End Negative Regulation Of Lens Fiber Cell Differentiation MRNA Cleavage Factor Complex Regulation Of Pro-B Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation MRNA Alternative Polyadenylation Positive Regulation Of Lymphoid Progenitor Cell Differentiation Positive Regulation Of Pro-B Cell Differentiation Ribonuclease III Activity Mitochondrial Translational Elongation Deoxyribonucleoside Monophosphate Biosynthetic Process Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Response To Phorbol 13-acetate 12-myristate Nucleus SMN Complex RNA Processing Identical Protein Binding Gemini Of Cajal Bodies Pyrimidine Nucleoside Metabolic Process Protein Complex Oligomerization Regulation Of Neurotrophin TRK Receptor Signaling Pathway Branch Elongation Of An Epithelium Paraspeckles Regulation Of Lymphoid Progenitor Cell Differentiation Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway
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