SPRY2 and CHRD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SPRY2	CHRD
Description		sprouty RTK signaling antagonist 2	chordin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Ruffle Membrane Cell Projection Microtubule End	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity Ubiquitin-protein Transferase Inhibitor Activity Molecular Function Inhibitor Activity	Protein Binding Cytokine Binding BMP Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Angiogenesis Lung Development Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Projection Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lung Morphogenesis Lung Growth Bud Elongation Involved In Lung Branching Respiratory System Development ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor	Skeletal System Development Positive Regulation Of Mesenchymal Cell Proliferation Pattern Specification Process Dorsal/ventral Pattern Formation Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion System Development
Pathways		Spry regulation of FGF signaling EGFR downregulation
Drugs
Diseases
GWAS		Adiposity ( 21706003) Adventurousness ( 30643258) Body fat percentage ( 26833246) Central corneal thickness ( 32528159) Diastolic blood pressure ( 30224653) Fasting blood insulin (BMI interaction) ( 22581228) General risk tolerance (MTAG) ( 30643258) Height ( 25282103 31562340) Insulin-related traits (multivariate analysis) ( 32002517) Lactose tolerance test ( 31791255) Leisure-time exercise behaviour (age-stratified) ( 30102679) Medication use (drugs used in diabetes) ( 31015401) Methadone dose in opioid dependence ( 28115739) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 20023658 22863734) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Sleep duration ( 25469926) Thrombocytopenia in coronary artery bypass surgery ( 30103242) Type 2 diabetes ( 29358691 30718926 32499647 31118516 30297969 30054458 28869590 26818947 24509480 22885922 20862305) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Diisocyanate-induced asthma ( 25918132) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet count ( 20139978 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		110 interacting genes: ADAMTSL4 AQP1 ATRIP BAG3 BRAF CATSPER1 CBL CBLB CBLC CHRD CHRNG CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 DSCR9 DYRK1A EIF4E2 FAIM FAM219A FBN1 FBXO7 FRS3 FXR1 FXR2 GNE GP9 GPRIN2 GRAP2 GRB2 GRN HEXIM2 HNRNPLL HOXA1 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1A LCE1B LCE1C LCE1F LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MB21D2 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 NUFIP2 OTX1 PACSIN3 PLSCR1 PRKAB2 PRKCD PRKD1 PTGER3 PTPN11 RAF1 RTF2 RUNX1T1 SDHB SEMA5B SH3KBP1 SHFL SIAH2 SPRY1 STK16 TCAF1 TMEM14B TNS2 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587	60 interacting genes: ADAMTSL4 ATN1 BMP1 BMP2 CATSPER1 CD36 CHRDL2 CYSRT1 F2R FXR1 FXR2 GATA1 HOXA1 HRG INCA1 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP19-2 KRTAP19-5 KRTAP22-1 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 LCE1C LCE1F LCE5A LIN7A MEOX2 NBPF19 NOTCH2NLA NR0B2 NR4A3 NUFIP2 OTX1 PLSCR1 POU4F2 RGS17 SLC15A2 SMAD3 SPRY1 SPRY2 SPRY3 TLL1 TRIM42 TSPAN4 TWSG1
Entrez ID		10253	8646
HPRD ID		03916	04592
Ensembl ID		ENSG00000136158	ENSG00000090539
Uniprot IDs		O43597	E7ESX1 Q8N2W7 Q9H2X0
PDB IDs		3BUM 3OB1 5HKY 5HKZ 5HL0
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Phosphotyrosine Residue Binding Identical Protein Binding Epidermis Development Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Binding Cytosol Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Receptor Tyrosine Kinase Binding SH3 Domain Binding Regulation Of Signal Transduction Regulation Of Translation At Presynapse, Modulating Synaptic Transmission ESCRT II Complex ERBB Signaling Pathway Tissue Development Ubiquitin-protein Transferase Activity Regulation Of Cell Activation Regulation Of Biological Quality Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Zinc Ion Binding Ubiquitin Protein Ligase Activity	Intermediate Filament Keratin Filament Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Epidermis Development Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Identical Protein Binding Positive Regulation Of Blood Coagulation Keratinization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Osteoblast Proliferation Pericardium Development Positive Regulation Of Coagulation Positive Regulation Of Cartilage Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Developmental Process Animal Organ Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of ERK1 And ERK2 Cascade Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesoderm Formation Regulation Of Ras Protein Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Transcription Coactivator Binding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Osteoblast Proliferation Branch Elongation Of An Epithelium Inner Ear Development Nuclear Glucocorticoid Receptor Binding Hair Cycle Ossification Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Inner Ear Morphogenesis Positive Regulation Of Cell-matrix Adhesion Formation Of Primary Germ Layer MAPK Cascade Epithelium Development Regulation Of Wound Healing Negative Regulation Of Small GTPase Mediated Signal Transduction
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