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SPRY2 and MDFI
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
SPRY2
MDFI
Gene Name
sprouty homolog 2 (Drosophila)
MyoD family inhibitor
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Microtubule
Plasma Membrane
Microtubule Cytoskeleton
Ruffle Membrane
Nucleus
Cytoplasm
Molecular Function
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Protein Binding
Transcription Factor Binding
Biological Process
Establishment Of Mitotic Spindle Orientation
Epidermal Growth Factor Receptor Signaling Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Ras GTPase Activity
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Cell Fate Commitment
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Lung Growth
Bud Elongation Involved In Lung Branching
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Activation Of JUN Kinase Activity
Embryo Development
Dorsal/ventral Axis Specification
Negative Regulation Of Wnt Signaling Pathway
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of DNA Binding
Embryonic Skeletal System Morphogenesis
Trophoblast Giant Cell Differentiation
Pathways
Signaling by EGFR
EGFR downregulation
Signaling by FGFR in disease
Signaling by EGFR in Cancer
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Spry regulation of FGF signaling
Signaling by FGFR
Negative regulation of FGFR signaling
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Fasting insulin-related traits (interaction with BMI) (
22581228
)
Orofacial clefts (
20023658
22863734
)
Type 2 diabetes (
20862305
)
Protein-Protein Interactions
90 interactors:
ADAMTSL4
AQP1
ATRIP
C19orf66
CATSPER1
CBL
CBLB
CBLC
CHRD
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
EIF4E2
FAIM
FAM219A
FBN1
FRS3
GNE
GP9
GPRIN2
GRAP2
GRB2
HEXIM2
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1B
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
OTX1
PACSIN3
PLSCR1
PRKAB2
PTGER3
PTPN11
RAF1
RTFDC1
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SIAH2
SPRY1
STK16
TCAF1
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
225 interactors:
AANAT
AASDHPPT
ADAMTSL3
AKAP17A
AP5Z1
APLN
AQP1
AQP5
ARHGAP32
ARID5A
ATG12
ATN1
ATXN7L2
AVPI1
B3GNT9
BAALC
BAHD1
BBS2
BEX1
C10orf62
C14orf105
C17orf70
C19orf60
C19orf66
C20orf195
C22orf39
C4orf26
C5orf30
C6orf165
C8orf33
C8orf48
CATSPER1
CBFA2T2
CBX2
CC2D1B
CCDC116
CCDC120
CCDC185
CCDC33
CCER1
CDC42EP1
CDCA7L
CDKL3
CEP57L1
CHIC2
CLPB
CNNM3
CPSF3L
CREB5
CRX
CRY1
CSNK1G2-AS1
CXCL16
CYBA
DAAM2
DBF4B
DCAF8
DCANP1
DDX19A
DHRS1
DKK1
DMRT3
DNPEP
DOCK2
DUSP6
EBI3
EIF4A2
EIF4E2
ENKD1
ETNK2
EWSR1
FAM124B
FAM161A
FAM27E3
FASTK
FBXL18
FBXO34
FBXW5
FES
FOXD4L6
FZD9
GATA2
GDF15
GLIDR
GNAI2
GNG5
GPATCH2L
GPRIN2
GTF3C5
HEYL
HNRNPLL
HOXA1
HOXB9
HTR1B
ILF3
IQUB
KAT5
KIAA0040
KIAA0408
KIF1A
KPNA2
KRAS
LASP1
LCE1B
LCE3E
LCE4A
LIMS2
LINC00636
LINC01588
LMO3
LOC148413
LOC149950
LRCH4
LRRN4
MAGED1
MAGEF1
MAPKBP1
MCM5
METTL17
MFSD3
MGAT5B
MVP
MYF5
MYOD1
MYOG
NAB2
NDUFA7
NEU4
NPDC1
NR1H2
NR1H3
OLIG3
OTX1
PARP11
PBXIP1
PDGFB
PDIA5
PGLS
PHLDA1
PID1
PIDD1
PIH1D2
PIN1
PLEKHG4
POM121L8P
PRKAB2
PTPMT1
PVRL2
RABL6
REG3A
RFX2
RIPPLY1
RTP5
SERF2
SFI1
SIX1
SLC25A10
SLC35A2
SLC9A1
SPATA3
SPATA8
SPG7
SPRY1
SPRY2
TAP1
TCEB3
TCF3
TGIF1
THAP7
THEG
TIE1
TINAGL1
TMEM241
TNNI1
TNP2
TRAF3IP2
TRPC1
TRPV6
TSC2
TTC23
TTLL10
TUSC2
TYMSOS
TYRO3
UBC
USP20
USP6
VHL
VPS72
WDYHV1
WNT11
ZBTB24
ZBTB25
ZBTB9
ZFYVE26
ZNF101
ZNF124
ZNF136
ZNF138
ZNF155
ZNF205
ZNF223
ZNF230
ZNF264
ZNF266
ZNF408
ZNF417
ZNF426
ZNF433
ZNF439
ZNF440
ZNF490
ZNF559
ZNF564
ZNF578
ZNF581
ZNF587
ZNF607
ZNF646
ZNF670
ZNF679
ZNF707
ZNF764
ZNF79
ZNF844
Entrez ID
10253
4188
HPRD ID
03916
07280
Ensembl ID
ENSG00000136158
ENSG00000112559
Uniprot IDs
O43597
B1AKB6
Q99750
PDB IDs
3BUM
3OB1
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Keratinization
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Signaling
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Process
Keratinocyte Differentiation
Regulation Of Cell Activation
Negative Regulation Of Protein Metabolic Process
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Death
System Development
Death
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cell-cell Adhesion
Developmental Process
Multicellular Organismal Development
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Regulation Of T Cell Activation
Cellular Response To Organic Substance
Cell Differentiation
Anatomical Structure Development
Organ Development
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Kinase Activity
Epidermal Cell Differentiation
Response To Growth Factor
Protein Modification By Small Protein Conjugation
Epithelium Development
Regulation Of Apoptotic Process
Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Kinase Activity
Regulation Of Immune System Process
Negative Regulation Of Cellular Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
RNA Metabolic Process
Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Biosynthetic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Regulation Of Cellular Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Cellular Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Cellular Metabolic Process
Negative Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Developmental Process
Cellular Response To Organic Substance
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Multicellular Organismal Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cell Differentiation
Positive Regulation Of Myoblast Fusion
Cell Fate Commitment
Positive Regulation Of Skeletal Muscle Fiber Development
Anatomical Structure Development
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion
Regulation Of Myoblast Fusion
Transcription From RNA Polymerase II Promoter
Organ Development
Metabolic Process
Tagcloud
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Difference)
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Intersection)
?