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SPRY2 and FXR2
Number of citations of the paper that reports this interaction (PubMedID
21653829
)
54
Data Source:
BioGRID
(two hybrid)
SPRY2
FXR2
Description
sprouty RTK signaling antagonist 2
FMR1 autosomal homolog 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Actin Cytoskeleton
Microtubule Cytoskeleton
Membrane
Ruffle Membrane
Cell Projection
Microtubule End
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
Membrane
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Synapse
Presynapse
Postsynapse
Molecular Function
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Ubiquitin-protein Transferase Inhibitor Activity
Molecular Function Inhibitor Activity
Nucleic Acid Binding
RNA Binding
MRNA Binding
MRNA 3'-UTR Binding
Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Translation Regulator Activity
Protein Heterodimerization Activity
Biological Process
Establishment Of Mitotic Spindle Orientation
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Angiogenesis
Lung Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Projection Organization
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Ras Protein Signal Transduction
Animal Organ Development
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lung Morphogenesis
Lung Growth
Bud Elongation Involved In Lung Branching
Respiratory System Development
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Lens Fiber Cell Differentiation
Cellular Response To Leukemia Inhibitory Factor
Regulation Of Translation
Dentate Gyrus Development
Regulation Of MRNA Stability
Positive Regulation Of Translation
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Animal Organ Development
MRNA Transport
MRNA Destabilization
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Pathways
Spry regulation of FGF signaling
EGFR downregulation
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Adventurousness (
30643258
)
Body fat percentage (
26833246
)
Central corneal thickness (
32528159
)
Diastolic blood pressure (
30224653
)
Fasting blood insulin (BMI interaction) (
22581228
)
General risk tolerance (MTAG) (
30643258
)
Height (
25282103
31562340
)
Insulin-related traits (multivariate analysis) (
32002517
)
Lactose tolerance test (
31791255
)
Leisure-time exercise behaviour (age-stratified) (
30102679
)
Medication use (drugs used in diabetes) (
31015401
)
Methadone dose in opioid dependence (
28115739
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Orofacial clefts (
20023658
22863734
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Sleep duration (
25469926
)
Thrombocytopenia in coronary artery bypass surgery (
30103242
)
Type 2 diabetes (
29358691
30718926
32499647
31118516
30297969
30054458
28869590
26818947
24509480
22885922
20862305
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Atrial fibrillation (
30061737
)
Brain morphology (MOSTest) (
32665545
)
IgM levels (
23118916
)
Monocyte count (
32888494
)
Refractive error (
32231278
)
Sex hormone-binding globulin levels (
22675492
)
Interacting Genes
110 interacting genes:
ADAMTSL4
AQP1
ATRIP
BAG3
BRAF
CATSPER1
CBL
CBLB
CBLC
CHRD
CHRNG
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
DSCR9
DYRK1A
EIF4E2
FAIM
FAM219A
FBN1
FBXO7
FRS3
FXR1
FXR2
GNE
GP9
GPRIN2
GRAP2
GRB2
GRN
HEXIM2
HNRNPLL
HOXA1
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1A
LCE1B
LCE1C
LCE1F
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MB21D2
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
NUFIP2
OTX1
PACSIN3
PLSCR1
PRKAB2
PRKCD
PRKD1
PTGER3
PTPN11
RAF1
RTF2
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SHFL
SIAH2
SPRY1
STK16
TCAF1
TMEM14B
TNS2
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
191 interacting genes:
AKAP9
AMOTL2
AP1M1
AP2M1
ARHGEF7
ARL6IP1
ATN1
AXIN1
AXIN2
BAZ2B
BCKDK
BCL11A
BLK
BRCA1
BYSL
C10orf62
C1orf35
CALCOCO2
CAMK2B
CAMK2G
CAPRIN1
CBS
CCAR2
CCDC33
CCDC85B
CCDC92
CCN3
CCR4
CDKL3
CEP44
CEP55
CHRD
COIL
COMT
CSNK2B
CWF19L2
CYFIP1
CYFIP2
DCTN2
DCTPP1
DDX17
DEAF1
DGKD
DMRTB1
DNM2
DPPA2
DYNLT1
ECH1
ECHS1
EDC4
EGFL7
EIF4G1
EVL
EWSR1
FAM90A1
FBP1
FMR1
FTH1
FXR1
GFAP
GKAP1
GOLGA2
GPSM1
GPSM2
GRIP1
GTSE1
HIVEP1
HMBOX1
HNRNPC
HNRNPM
HNRNPR
HOMER3
HSPB1
IGFN1
IMPDH2
INPP5J
KCNRG
KCTD4
KHDRBS1
KIAA1217
KIF1A
KIF2A
KIF7
KRT18
KRT20
KXD1
L3MBTL1
L3MBTL3
LASP1
LCMT1
LCP2
LDOC1
MAGED1
MAPKBP1
MAPRE3
MBIP
MCRS1
MEAF6
MFAP1
MIA3
MORF4L1
MPP1
MRPL43
MSANTD3
MVP
MYH10
NASP
NCK2
NDEL1
NDN
NECAB2
NEXN
NIF3L1
NKD2
NME1
NME3
NONO
NT5C2
PAF1
PAICS
PCBD1
PCM1
PDE9A
PHC1P1
PHC2
PHLDB1
PICK1
PIM1
PKM
PNMA1
POM121
PPP1R12C
PRAM1
PRC1
PRPF6
PSME1
PSME3
PTS
PYCR2
PYCR3
RABAC1
RAD54L2
RAI2
RALYL
RBBP8
RBM14
RBM45
RBMX
RBPMS
RPIA
RPS2
RTN3
RTN4
SCEL
SCMH1
SF3B2
SFPQ
SNAP23
SPRY1
SPRY2
SRPK2
SYT6
SYTL4
TBC1D22B
TFCP2
THAP1
TLE5
TNFAIP1
TNIP2
TNNT1
TRAF2
TRIM23
TRIM29
TRIM3
TRIM37
TRIOBP
TSC22D4
TUT4
USP39
VIM
WDR59
WEE2-AS1
YES1
ZBTB22
ZBTB8A
ZMAT2
ZMYND8
ZNF232
ZNF451
ZNRD2
ZSCAN1
Entrez ID
10253
9513
HPRD ID
03916
05629
Ensembl ID
ENSG00000136158
ENSG00000129245
Uniprot IDs
O43597
P51116
PDB IDs
3BUM
3OB1
5HKY
5HKZ
5HL0
3H8Z
Enriched GO Terms of Interacting Partners
?
Intermediate Filament
Keratin Filament
Keratinization
Phosphotyrosine Residue Binding
Identical Protein Binding
Epidermis Development
Negative Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Binding
Cytosol
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Receptor Tyrosine Kinase Binding
SH3 Domain Binding
Regulation Of Signal Transduction
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
ESCRT II Complex
ERBB Signaling Pathway
Tissue Development
Ubiquitin-protein Transferase Activity
Regulation Of Cell Activation
Regulation Of Biological Quality
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
Identical Protein Binding
Protein Binding
Cytoplasm
Cytosol
Cytoskeleton
Negative Regulation Of RNA Metabolic Process
Neuron Projection
MRNA Metabolic Process
MRNA Processing
MRNA Splicing, Via Spliceosome
RNA Splicing
RNA Splicing, Via Transesterification Reactions
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Establishment Of Mitotic Spindle Orientation
Paraspeckles
Nucleoplasm
Regulation Of RNA Metabolic Process
Centrosome
Regulation Of Neurotrophin TRK Receptor Signaling Pathway
MRNA Binding
Negative Regulation Of DNA-templated Transcription
Establishment Of Mitotic Spindle Localization
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Cellular Component Organization
Negative Regulation Of Macromolecule Metabolic Process
Establishment Of Spindle Orientation
Microtubule-based Process
Microtubule Cytoskeleton Organization Involved In Mitosis
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleolus
Regulation Of MRNA Metabolic Process
Endoplasmic Reticulum Tubular Network Formation
Regulation Of Dendritic Spine Development
RNA Binding
Signaling Adaptor Activity
Negative Regulation Of Metabolic Process
Establishment Of Spindle Localization
Negative Regulation Of Centriole Replication
Intracellular Membraneless Organelle
Establishment Of Organelle Localization
Protein Domain Specific Binding
Spindle Localization
Regulation Of DNA-templated Transcription
Regulation Of Cell Projection Organization
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Dendritic Spine Development
Endoplasmic Reticulum Tubular Network Membrane Organization
System Development
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Tagcloud (Difference)
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Tagcloud (Intersection)
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