DGCR6 and CBLL1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		DGCR6	CBLL1
Description		DiGeorge syndrome critical region gene 6	Cbl proto-oncogene like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Extracellular Matrix	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Adhesion Animal Organ Morphogenesis	MRNA Processing Negative Regulation Of Cell Adhesion Protein Ubiquitination Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Endocytosis Cell-cell Adhesion
Pathways			InlA-mediated entry of Listeria monocytogenes into host cells Degradation of CDH1
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Metabolite levels ( 23823483) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		67 interacting genes: ADAMTSL4 AGTRAP AKAP8L APP ARNT2 C1orf94 C3orf62 CBLL1 CBY2 CCDC33 CEP126 CTBP1 DEUP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 ESS2 FBF1 FH FTCD GOLGA2 GSE1 HGS HOMEZ IHO1 IKZF3 INIP KLHL12 KRTAP12-2 LZTS2 MBIP MEIS2 MEOX2 MIA2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NLA NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPRY2 SS18L1 TCF12 TCF4 TFIP11 TLE5 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446	7 interacting genes: CDC42 CDH1 DGCR6 ESR1 OGT RBM10 YWHAQ
Entrez ID		8214	79872
HPRD ID		03177	07590
Ensembl ID		ENSG00000183628	ENSG00000105879
Uniprot IDs		Q14129 X5D7D2	B4DDV7 Q75N03
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Neuron Differentiation PTB Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Macromolecule Metabolic Process Nuclear Pore Central Transport Channel Regulation Of Transcription By RNA Polymerase II Microtubule Spindle Pole Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Thioesterase Binding Positive Regulation Of Metabolic Process DNA Binding Regulation Of Neuron Differentiation Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Ras Protein Signal Transduction Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Protein-containing Complex Intracellular Protein Localization Substantia Nigra Development Neural Nucleus Development Adherens Junction Organization Identical Protein Binding Regulation Of Smooth Muscle Cell Apoptotic Process 14-3-3 Protein Binding Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Endothelin Receptor Signaling Pathway Involved In Heart Process Glutamatergic Synapse GBD Domain Binding Negative Regulation Of Protein-containing Complex Assembly Storage Vacuole Beta-catenin Binding Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of RNA Metabolic Process Prostate Epithelial Cord Elongation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of RNA Biosynthetic Process Smooth Muscle Cell Apoptotic Process Protein O-acetylglucosaminyltransferase Activity Apolipoprotein A-I Receptor Binding Anatomical Structure Morphogenesis Neuropilin Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Negative Regulation Of Ribosome Biogenesis Regulation Of Transport Response To Heparin Cellular Response To Indole-3-methanol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cell-cell Junction Organization Negative Regulation Of Cellular Component Organization Response To Indole-3-methanol Response To Gram-positive Bacterium Regulation Of Ribosome Biogenesis Vascular Associated Smooth Muscle Cell Proliferation
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