DGCR6 and DLGAP2

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		DGCR6	DLGAP2
Description		DiGeorge syndrome critical region gene 6	DLG associated protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Extracellular Matrix	Neurofilament Plasma Membrane Postsynaptic Density Membrane Synapse Glutamatergic Synapse Postsynaptic Specialization
	Molecular Function	Protein Binding	Protein Binding Molecular Adaptor Activity
	Biological Process	Cell Adhesion Animal Organ Morphogenesis	Neuron-neuron Synaptic Transmission Signaling Modulation Of Chemical Synaptic Transmission
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Metabolite levels ( 23823483) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)	Bipolar disorder ( 31043756) Daytime nap ( 33568662) End-stage renal disease ( 29885931) Eye morphology ( 29921221) Femur bone mineral density x serum urate levels interaction ( 34046847) Lung cancer ( 28604730) Menarche (age at onset) ( 23599027) Neuritic plaque ( 31497858) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive astigmatism ( 30306274) Stroke ( 32693751) Tau burden ( 33426524) Triglycerides ( 24886709) White matter microstructure in first episode schizophrenia (right posterior cingulate cortex) ( 28924203)
Interacting Genes		67 interacting genes: ADAMTSL4 AGTRAP AKAP8L APP ARNT2 C1orf94 C3orf62 CBLL1 CBY2 CCDC33 CEP126 CTBP1 DEUP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 ESS2 FBF1 FH FTCD GOLGA2 GSE1 HGS HOMEZ IHO1 IKZF3 INIP KLHL12 KRTAP12-2 LZTS2 MBIP MEIS2 MEOX2 MIA2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NLA NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPRY2 SS18L1 TCF12 TCF4 TFIP11 TLE5 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446	18 interacting genes: ABI2 ADRB1 CYSRT1 DGCR6 DLG2 DLG4 DLGAP1 GRK5 KRT40 KRTAP4-2 MAGI2 NLGN4X NOS1 SHANK2 SHANK3 SORBS2 TSPOAP1 UBASH3B
Entrez ID		8214	9228
HPRD ID		03177	09258
Ensembl ID		ENSG00000183628	ENSG00000198010
Uniprot IDs		Q14129 X5D7D2	A0A1B0GTN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Neuron Differentiation PTB Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Macromolecule Metabolic Process Nuclear Pore Central Transport Channel Regulation Of Transcription By RNA Polymerase II Microtubule Spindle Pole Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Thioesterase Binding Positive Regulation Of Metabolic Process DNA Binding Regulation Of Neuron Differentiation Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Ras Protein Signal Transduction Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Postsynaptic Density Vocalization Behavior Ionotropic Glutamate Receptor Binding Receptor Clustering Synapse Social Behavior Dendritic Spine Scaffold Protein Binding Beta-1 Adrenergic Receptor Binding Synaptic Receptor Adaptor Activity AMPA Glutamate Receptor Clustering Modulation Of Chemical Synaptic Transmission Modulation Of Excitatory Postsynaptic Potential Learning Neuron Projection Cell Projection Synaptic Signaling Neuron Spine Photoreceptor Inner Segment Juxtaparanode Region Of Axon Regulation Of Membrane Potential Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Postsynaptic Membrane Dendritic Spine Morphogenesis Kinase Binding Postsynaptic Density Membrane Learning Or Memory Calyx Of Held Response To Potassium Ion SH3 Domain Binding Cytoskeletal Anchor Activity Regulation Of System Process Regulation Of Nervous System Process Regulation Of Cell Communication Regulation Of Signaling Protein Localization To Membrane Chemical Synaptic Transmission Cognition Regulation Of The Force Of Heart Contraction Regulation Of Long-term Neuronal Synaptic Plasticity Cell-cell Signaling Trans-synaptic Signaling Signaling Excitatory Synapse Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Adult Behavior Cell Communication
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