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SPRY2 and MAPKBP1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
SPRY2
MAPKBP1
Gene Name
sprouty homolog 2 (Drosophila)
mitogen-activated protein kinase binding protein 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Microtubule
Plasma Membrane
Microtubule Cytoskeleton
Ruffle Membrane
Molecular Function
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Biological Process
Establishment Of Mitotic Spindle Orientation
Epidermal Growth Factor Receptor Signaling Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Ras GTPase Activity
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Cell Fate Commitment
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Lung Growth
Bud Elongation Involved In Lung Branching
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Signaling by EGFR
EGFR downregulation
Signaling by FGFR in disease
Signaling by EGFR in Cancer
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Spry regulation of FGF signaling
Signaling by FGFR
Negative regulation of FGFR signaling
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Fasting insulin-related traits (interaction with BMI) (
22581228
)
Orofacial clefts (
20023658
22863734
)
Type 2 diabetes (
20862305
)
Protein-Protein Interactions
90 interactors:
ADAMTSL4
AQP1
ATRIP
C19orf66
CATSPER1
CBL
CBLB
CBLC
CHRD
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
EIF4E2
FAIM
FAM219A
FBN1
FRS3
GNE
GP9
GPRIN2
GRAP2
GRB2
HEXIM2
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1B
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
OTX1
PACSIN3
PLSCR1
PRKAB2
PTGER3
PTPN11
RAF1
RTFDC1
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SIAH2
SPRY1
STK16
TCAF1
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
31 interactors:
ADAMTSL4
ALG13
APTX
GLRX3
KEAP1
KRT31
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-2
KRTAP4-12
KRTAP5-9
KRTAP9-2
KRTAP9-4
MAPK10
MAPK8
MAPK9
MDFI
MEOX2
NOTCH2NL
RGS20
SIAH1
SPRY2
TCF12
TCF4
TEX11
TRIM27
TRIP6
Entrez ID
10253
23005
HPRD ID
03916
17465
Ensembl ID
ENSG00000136158
ENSG00000137802
Uniprot IDs
O43597
O60336
PDB IDs
3BUM
3OB1
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Keratinization
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Signaling
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Process
Keratinocyte Differentiation
Regulation Of Cell Activation
Negative Regulation Of Protein Metabolic Process
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Death
System Development
Death
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cell-cell Adhesion
Developmental Process
Multicellular Organismal Development
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Regulation Of T Cell Activation
Cellular Response To Organic Substance
Cell Differentiation
Anatomical Structure Development
Organ Development
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Kinase Activity
Epidermal Cell Differentiation
Response To Growth Factor
Protein Modification By Small Protein Conjugation
Epithelium Development
Regulation Of Apoptotic Process
Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Kinase Activity
Regulation Of Immune System Process
Negative Regulation Of Cellular Metabolic Process
JUN Phosphorylation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
JNK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Signal Transduction
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
Regulation Of Gene Expression
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Circadian Rhythm
Signal Transduction By Phosphorylation
Toll-like Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Regulation Of Apoptotic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Cell Death
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Metabolic Process
Activation Of Innate Immune Response
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Protein Localization
Regulation Of Intracellular Transport
Positive Regulation Of Innate Immune Response
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Signaling
Positive Regulation Of Apoptotic Signaling Pathway
Developmental Process
Regulation Of Nucleocytoplasmic Transport
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Fc-epsilon Receptor Signaling Pathway
Tagcloud
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Difference)
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Intersection)
?