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SPRY2 and LONRF1
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
SPRY2
LONRF1
Description
sprouty RTK signaling antagonist 2
LON peptidase N-terminal domain and ring finger 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Actin Cytoskeleton
Microtubule Cytoskeleton
Membrane
Ruffle Membrane
Cell Projection
Microtubule End
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Ubiquitin-protein Transferase Inhibitor Activity
Molecular Function Inhibitor Activity
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Biological Process
Establishment Of Mitotic Spindle Orientation
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Angiogenesis
Lung Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Projection Organization
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Ras Protein Signal Transduction
Animal Organ Development
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lung Morphogenesis
Lung Growth
Bud Elongation Involved In Lung Branching
Respiratory System Development
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Lens Fiber Cell Differentiation
Cellular Response To Leukemia Inhibitory Factor
Pathways
Spry regulation of FGF signaling
EGFR downregulation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Adventurousness (
30643258
)
Body fat percentage (
26833246
)
Central corneal thickness (
32528159
)
Diastolic blood pressure (
30224653
)
Fasting blood insulin (BMI interaction) (
22581228
)
General risk tolerance (MTAG) (
30643258
)
Height (
25282103
31562340
)
Insulin-related traits (multivariate analysis) (
32002517
)
Lactose tolerance test (
31791255
)
Leisure-time exercise behaviour (age-stratified) (
30102679
)
Medication use (drugs used in diabetes) (
31015401
)
Methadone dose in opioid dependence (
28115739
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Orofacial clefts (
20023658
22863734
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Sleep duration (
25469926
)
Thrombocytopenia in coronary artery bypass surgery (
30103242
)
Type 2 diabetes (
29358691
30718926
32499647
31118516
30297969
30054458
28869590
26818947
24509480
22885922
20862305
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Apolipoprotein A1 levels (
32203549
)
Colorectal cancer (diet interaction) (
24743840
)
HDL cholesterol levels (
32203549
)
Interacting Genes
110 interacting genes:
ADAMTSL4
AQP1
ATRIP
BAG3
BRAF
CATSPER1
CBL
CBLB
CBLC
CHRD
CHRNG
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
DSCR9
DYRK1A
EIF4E2
FAIM
FAM219A
FBN1
FBXO7
FRS3
FXR1
FXR2
GNE
GP9
GPRIN2
GRAP2
GRB2
GRN
HEXIM2
HNRNPLL
HOXA1
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1A
LCE1B
LCE1C
LCE1F
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MB21D2
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
NUFIP2
OTX1
PACSIN3
PLSCR1
PRKAB2
PRKCD
PRKD1
PTGER3
PTPN11
RAF1
RTF2
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SHFL
SIAH2
SPRY1
STK16
TCAF1
TMEM14B
TNS2
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
98 interacting genes:
ADAMTSL4
ALAS1
AP2B1
ATG9A
AVPI1
BRCA1
BYSL
C4orf17
CALCOCO2
CBLL2
CDKN2D
CFP
CRX
CYSRT1
DSCR9
DVL3
EFHC2
FLACC1
GABPB2
GORASP1
GORASP2
GPRASP3
HLX
HOXA1
HSPB1
IHO1
IKZF2
IKZF3
IQCF2
KAT5
KATNBL1
KCTD21
KCTD9
KHDC1
KRT31
KRT35
KRT75
KRTAP1-3
KRTAP13-1
KRTAP13-3
KRTAP19-6
KRTAP19-7
KRTAP3-3
KRTAP6-1
LGALS9B
LHX2
LHX4
LNX1
MAGED1
MGAT5B
MID2
MRPL38
MTMR3
MYOZ3
NR4A1
NTAQ1
OOEP
PATZ1
PAX5
PAX6
PAX8
PICK1
PLSCR1
POU6F2
PPP1R3C
PRDM16
PRDM6
PRR35
PSMA1
RBPMS
RIMBP3C
RPRD1A
RSPH1
SFN
SLU7
SPRY2
STAU1
STX11
TASOR2
TBX19
TRAF2
TRIM27
TRIM42
TRIM8
TRIM9
UBE2I
UBE2L6
UCHL3
USP2
VGLL1
WDR83
XIAP
YPEL3
ZFP90
ZNF426
ZNF653
ZNF774
ZNHIT2
Entrez ID
10253
91694
HPRD ID
03916
08674
Ensembl ID
ENSG00000136158
ENSG00000154359
Uniprot IDs
O43597
Q17RB8
PDB IDs
3BUM
3OB1
5HKY
5HKZ
5HL0
Enriched GO Terms of Interacting Partners
?
Intermediate Filament
Keratin Filament
Keratinization
Phosphotyrosine Residue Binding
Identical Protein Binding
Epidermis Development
Negative Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Binding
Cytosol
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Receptor Tyrosine Kinase Binding
SH3 Domain Binding
Regulation Of Signal Transduction
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
ESCRT II Complex
ERBB Signaling Pathway
Tissue Development
Ubiquitin-protein Transferase Activity
Regulation Of Cell Activation
Regulation Of Biological Quality
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
Intermediate Filament
Protein Binding
Zinc Ion Binding
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Identical Protein Binding
Keratin Filament
Post-translational Protein Modification
Positive Regulation Of RNA Metabolic Process
Ubiquitin Protein Ligase Activity
Regulation Of DNA-templated Transcription
Transcription Coactivator Activity
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Positive Regulation Of Macromolecule Biosynthetic Process
Protein Kinase C Inhibitor Activity
Negative Regulation Of Viral Transcription
Suppression Of Viral Release By Host
Positive Regulation Of Biosynthetic Process
Regulation Of Viral Transcription
Regulation Of RNA Metabolic Process
Protein Modification Process
Establishment Of Spindle Localization
Structural Constituent Of Skin Epidermis
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Spindle Localization
Non-canonical Inflammasome Complex Assembly
Telencephalon Regionalization
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Outer Dense Fiber
Regulation Of Gene Expression
Positive Regulation Of Transcription By RNA Polymerase II
Cytosol
Protein K63-linked Ubiquitination
Negative Regulation Of Viral Process
Positive Regulation Of Macromolecule Metabolic Process
Nucleus
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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