DGCR6 and RABGEF1

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		DGCR6	RABGEF1
Gene Name		DiGeorge syndrome critical region gene 6	RAB guanine nucleotide exchange factor (GEF) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Nucleus	Early Endosome Vesicle Recycling Endosome
	Molecular Function	Molecular_function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Cell Adhesion Organ Morphogenesis	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Protein Ubiquitination Positive Regulation Of Rab GTPase Activity Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Kit Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Aortic root size ( 21223598)
Protein-Protein Interactions		61 interactors: ADAMTSL4 AES AGTRAP APP ARNT2 C1orf94 C3orf62 CBLL1 CCDC33 CCDC36 CCDC67 CTAGE5 CTBP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 FBF1 GOLGA2 GSE1 HGS HOMEZ IKZF3 KIAA1377 KLHL12 LZTS2 MBIP MEIS2 MEOX2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NL NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPERT SPRY2 SS18L1 TCF12 TCF4 TFIP11 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446	30 interactors: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 GGA1 GGA2 HRAS KXD1 L1CAM MON1A MON1B RAB21 RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C
Entrez ID		8214	27342
HPRD ID		03177	11477
Ensembl ID		ENSG00000183628	ENSG00000243335
Uniprot IDs		Q14129	B4DZM7 Q9UJ41
PDB IDs			1TXU 2C7M 2C7N 2OT3
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of ERBB Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Death Developmental Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of ERBB Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Modification By Small Protein Conjugation Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Intracellular Transport Of Virus Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Intracellular Transport Positive Regulation Of Innate Immune Response Establishment Of Localization In Cell Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein Transport Innate Immune Response DNA-templated Transcription, Initiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Type I Interferon Production Viral Protein Processing Response To Growth Factor Establishment Of Protein Localization Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Immune System Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Innate Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Immune Response-regulating Signaling Pathway Cellular Localization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Immune Response Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		1rn antidopaminergic daao darpp dgcr2 drd2 drd3 dtnbp1 evolves facets forcefully g72 gabra1 gabra6 gabrp gria1 grin1 grm3 merge mglu2 networking prodh rgs4 slc1a2 slc1a6 underpinned unifying vulnerablility zdhhc8	abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Difference) ?		1rn antidopaminergic daao darpp dgcr2 drd2 drd3 dtnbp1 evolves facets forcefully g72 gabra1 gabra6 gabrp gria1 grin1 grm3 merge mglu2 networking prodh rgs4 slc1a2 slc1a6 underpinned unifying vulnerablility zdhhc8	abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Intersection) ?