SPRY2 and USP20

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPRY2	USP20
Gene Name		sprouty homolog 2 (Drosophila)	ubiquitin specific peptidase 20
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Plasma Membrane Microtubule Cytoskeleton Ruffle Membrane	Centrosome Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity	G-protein Coupled Receptor Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Epidermal Growth Factor Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Cell Fate Commitment Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Lung Growth Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity	Endocytosis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Signaling by EGFR EGFR downregulation Signaling by FGFR in disease Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Spry regulation of FGF signaling Signaling by FGFR Negative regulation of FGFR signaling
Drugs
Diseases
GWAS		Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) Orofacial clefts ( 20023658 22863734) Type 2 diabetes ( 20862305)
Protein-Protein Interactions		90 interactors: ADAMTSL4 AQP1 ATRIP C19orf66 CATSPER1 CBL CBLB CBLC CHRD CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 EIF4E2 FAIM FAM219A FBN1 FRS3 GNE GP9 GPRIN2 GRAP2 GRB2 HEXIM2 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1B LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 OTX1 PACSIN3 PLSCR1 PRKAB2 PTGER3 PTPN11 RAF1 RTFDC1 RUNX1T1 SDHB SEMA5B SH3KBP1 SIAH2 SPRY1 STK16 TCAF1 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587	20 interactors: ALAS1 BEND5 BEND7 CCDC36 DIO2 FATE1 HIF1A MAGEA11 MDFI PJA1 PLA2G2A PRKCI RAD17 SPRY2 TRIM23 USP15 USP21 USP28 VAPB VHL
Entrez ID		10253	10868
HPRD ID		03916	07505
Ensembl ID		ENSG00000136158	ENSG00000136878
Uniprot IDs		O43597	Q9Y2K6
PDB IDs		3BUM 3OB1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Keratinization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process Keratinocyte Differentiation Regulation Of Cell Activation Negative Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Cell Death System Development Death Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Developmental Process Multicellular Organismal Development Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of T Cell Activation Cellular Response To Organic Substance Cell Differentiation Anatomical Structure Development Organ Development Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase Activity Epidermal Cell Differentiation Response To Growth Factor Protein Modification By Small Protein Conjugation Epithelium Development Regulation Of Apoptotic Process Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Kinase Activity Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process	Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Metabolic Process Histone Deubiquitination Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Localization Within Membrane Protein Catabolic Process Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation By Host Of Viral Release From Host Cell Neural Fold Elevation Formation Embryonic Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Membrane Budding Histone H2B Conserved C-terminal Lysine Deubiquitination Elastin Metabolic Process Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Thyroid Hormone Catabolic Process Response To Interleukin-1 Regulation Of Cell Proliferation Positive Regulation Of Cell Differentiation Regulation Of Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Stimulus Cellular Response To Decreased Oxygen Levels Positive Regulation Of Catalytic Activity Cellular Protein Modification Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Negative Regulation Of Apoptotic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Establishment Of Cell Polarity Cellular Response To Oxygen Levels Response To Stimulus Protein Metabolic Process Embryonic Placenta Development
Tagcloud ?		beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger	ablated adrenergic arrestin ars betaar blocker carvedilol desensitization deubiquitinases e3 endogenously flag hek interacted internalized itinerary ligase lysosomal machineries march2 proteomics recruit recycling serves stabilized ubiquitinated ubiquitination usp33 vsmcs
Tagcloud (Difference) ?		beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger	ablated adrenergic arrestin ars betaar blocker carvedilol desensitization deubiquitinases e3 endogenously flag hek interacted internalized itinerary ligase lysosomal machineries march2 proteomics recruit recycling serves stabilized ubiquitinated ubiquitination usp33 vsmcs
Tagcloud (Intersection) ?