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SPRY2 and UBASH3B
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
SPRY2
UBASH3B
Description
sprouty RTK signaling antagonist 2
ubiquitin associated and SH3 domain containing B
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Actin Cytoskeleton
Microtubule Cytoskeleton
Membrane
Ruffle Membrane
Cell Projection
Microtubule End
Nucleus
Cytoplasm
Molecular Function
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Ubiquitin-protein Transferase Inhibitor Activity
Molecular Function Inhibitor Activity
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Biological Process
Establishment Of Mitotic Spindle Orientation
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Angiogenesis
Lung Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Projection Organization
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Ras Protein Signal Transduction
Animal Organ Development
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lung Morphogenesis
Lung Growth
Bud Elongation Involved In Lung Branching
Respiratory System Development
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Lens Fiber Cell Differentiation
Cellular Response To Leukemia Inhibitory Factor
Signal Transduction
Negative Regulation Of Signal Transduction
Platelet Activation
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Collagen-activated Signaling Pathway
Regulation Of Osteoclast Differentiation
Negative Regulation Of Osteoclast Differentiation
Negative Regulation Of Bone Resorption
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Platelet Aggregation
Negative Regulation Of Platelet Aggregation
Pathways
Spry regulation of FGF signaling
EGFR downregulation
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Adventurousness (
30643258
)
Body fat percentage (
26833246
)
Central corneal thickness (
32528159
)
Diastolic blood pressure (
30224653
)
Fasting blood insulin (BMI interaction) (
22581228
)
General risk tolerance (MTAG) (
30643258
)
Height (
25282103
31562340
)
Insulin-related traits (multivariate analysis) (
32002517
)
Lactose tolerance test (
31791255
)
Leisure-time exercise behaviour (age-stratified) (
30102679
)
Medication use (drugs used in diabetes) (
31015401
)
Methadone dose in opioid dependence (
28115739
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Orofacial clefts (
20023658
22863734
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Sleep duration (
25469926
)
Thrombocytopenia in coronary artery bypass surgery (
30103242
)
Type 2 diabetes (
29358691
30718926
32499647
31118516
30297969
30054458
28869590
26818947
24509480
22885922
20862305
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Apolipoprotein A1 levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Blood urea nitrogen levels (
31152163
)
Cholesterol, total (
25961943
20686565
24097068
)
Chronotype (
30696823
)
Diastolic blood pressure (
30224653
)
Eye length (
30174134
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
HDL cholesterol (
24097068
20686565
)
HDL cholesterol levels (
32203549
)
High density lipoprotein cholesterol levels (
33339817
)
High light scatter reticulocyte percentage of red cells (
32888494
)
LDL cholesterol levels (
32203549
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Pemphigus vulgaris (
29857070
)
Serum immune biomarker levels (
32066700
)
Stroke (
26089329
)
Systolic blood pressure (
30578418
)
Total cholesterol levels (
28334899
)
Interacting Genes
110 interacting genes:
ADAMTSL4
AQP1
ATRIP
BAG3
BRAF
CATSPER1
CBL
CBLB
CBLC
CHRD
CHRNG
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
DSCR9
DYRK1A
EIF4E2
FAIM
FAM219A
FBN1
FBXO7
FRS3
FXR1
FXR2
GNE
GP9
GPRIN2
GRAP2
GRB2
GRN
HEXIM2
HNRNPLL
HOXA1
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1A
LCE1B
LCE1C
LCE1F
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MB21D2
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
NUFIP2
OTX1
PACSIN3
PLSCR1
PRKAB2
PRKCD
PRKD1
PTGER3
PTPN11
RAF1
RTF2
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SHFL
SIAH2
SPRY1
STK16
TCAF1
TMEM14B
TNS2
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
51 interacting genes:
BBC3
CBL
CBLB
CCDC74B
CUL3
DAZAP2
DISC1
DLGAP2
DMRT3
DOC2A
DTX3
EFS
FAM168A
HOXB2
INCA1
JAK2
KAT5
KDM1A
KHDRBS1
KPRP
LMO2
LZTS2
MAP3K1
PIAS2
PKP4
PRKN
PRR35
PSMB1
PTPN21
RCHY1
REL
RNF216
RNF41
SHC1
SLC25A48
SPRY2
SYK
TCF4
TEPSIN
TNKS
TP53BP2
UBB
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
VPS37B
WASL
Entrez ID
10253
84959
HPRD ID
03916
16463
Ensembl ID
ENSG00000136158
ENSG00000154127
Uniprot IDs
O43597
Q8TF42
PDB IDs
3BUM
3OB1
5HKY
5HKZ
5HL0
2CPW
2E5K
5VR6
5W5G
8U5M
8U7E
Enriched GO Terms of Interacting Partners
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Intermediate Filament
Keratin Filament
Keratinization
Phosphotyrosine Residue Binding
Identical Protein Binding
Epidermis Development
Negative Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Binding
Cytosol
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Receptor Tyrosine Kinase Binding
SH3 Domain Binding
Regulation Of Signal Transduction
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
ESCRT II Complex
ERBB Signaling Pathway
Tissue Development
Ubiquitin-protein Transferase Activity
Regulation Of Cell Activation
Regulation Of Biological Quality
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Protein Ubiquitination
Protein Modification Process
Macromolecule Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Ubiquitin Protein Ligase Activity
Proteolysis
Ubiquitin Conjugating Enzyme Activity
Positive Regulation Of Protein Ubiquitination
Protein Autoubiquitination
Protein Metabolic Process
Positive Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Post-translational Protein Modification
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Transferase Activity
Catabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Metabolic Process
Protein Monoubiquitination
Receptor Tyrosine Kinase Binding
Positive Regulation Of Metabolic Process
Protein Binding
Regulation Of Protein Metabolic Process
Protein K11-linked Ubiquitination
Phosphotyrosine Residue Binding
Cytosol
SH3 Domain Binding
Regulation Of Primary Metabolic Process
Regulation Protein Catabolic Process At Postsynapse
Apoptotic Signaling Pathway
Macromolecule Metabolic Process
Organelle Localization
P53 Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Protein Polymerization
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Positive Regulation Of Cellular Component Organization
Cell Surface Receptor Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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