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SPRY2 and ATRIP
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
SPRY2
ATRIP
Description
sprouty RTK signaling antagonist 2
ATR interacting protein
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Actin Cytoskeleton
Microtubule Cytoskeleton
Membrane
Ruffle Membrane
Cell Projection
Microtubule End
Nucleus
Nucleoplasm
ATR-ATRIP Complex
Molecular Function
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Ubiquitin-protein Transferase Inhibitor Activity
Molecular Function Inhibitor Activity
Protein Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Establishment Of Mitotic Spindle Orientation
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Angiogenesis
Lung Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Projection Organization
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Ras Protein Signal Transduction
Animal Organ Development
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lung Morphogenesis
Lung Growth
Bud Elongation Involved In Lung Branching
Respiratory System Development
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Lens Fiber Cell Differentiation
Cellular Response To Leukemia Inhibitory Factor
DNA Damage Checkpoint Signaling
Nucleobase-containing Compound Metabolic Process
DNA Repair
DNA Damage Response
Regulation Of Double-strand Break Repair
Pathways
Spry regulation of FGF signaling
EGFR downregulation
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Adventurousness (
30643258
)
Body fat percentage (
26833246
)
Central corneal thickness (
32528159
)
Diastolic blood pressure (
30224653
)
Fasting blood insulin (BMI interaction) (
22581228
)
General risk tolerance (MTAG) (
30643258
)
Height (
25282103
31562340
)
Insulin-related traits (multivariate analysis) (
32002517
)
Lactose tolerance test (
31791255
)
Leisure-time exercise behaviour (age-stratified) (
30102679
)
Medication use (drugs used in diabetes) (
31015401
)
Methadone dose in opioid dependence (
28115739
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Orofacial clefts (
20023658
22863734
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Sleep duration (
25469926
)
Thrombocytopenia in coronary artery bypass surgery (
30103242
)
Type 2 diabetes (
29358691
30718926
32499647
31118516
30297969
30054458
28869590
26818947
24509480
22885922
20862305
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Interacting Genes
110 interacting genes:
ADAMTSL4
AQP1
ATRIP
BAG3
BRAF
CATSPER1
CBL
CBLB
CBLC
CHRD
CHRNG
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
DSCR9
DYRK1A
EIF4E2
FAIM
FAM219A
FBN1
FBXO7
FRS3
FXR1
FXR2
GNE
GP9
GPRIN2
GRAP2
GRB2
GRN
HEXIM2
HNRNPLL
HOXA1
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1A
LCE1B
LCE1C
LCE1F
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MB21D2
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
NUFIP2
OTX1
PACSIN3
PLSCR1
PRKAB2
PRKCD
PRKD1
PTGER3
PTPN11
RAF1
RTF2
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SHFL
SIAH2
SPRY1
STK16
TCAF1
TMEM14B
TNS2
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
28 interacting genes:
BRCA1
C1orf94
CCDC28B
CDC23
CDC6
CDK16
CEP164
CINP
ETAA1
FAAP100
FAM156A
LNX1
MCM2
MCM3
MCM5
MCM6
METTL21A
MID2
MOS
MX2
POLR1C
PRKDC
RPA3
SCG2
SIRT2
SPRY2
TASOR2
ZBTB14
Entrez ID
10253
84126
HPRD ID
03916
Ensembl ID
ENSG00000136158
ENSG00000164053
Uniprot IDs
O43597
Q8WXE1
PDB IDs
3BUM
3OB1
5HKY
5HKZ
5HL0
4IGK
4NB3
5YZ0
7XV4
Enriched GO Terms of Interacting Partners
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Intermediate Filament
Keratin Filament
Keratinization
Phosphotyrosine Residue Binding
Identical Protein Binding
Epidermis Development
Negative Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Binding
Cytosol
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Receptor Tyrosine Kinase Binding
SH3 Domain Binding
Regulation Of Signal Transduction
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
ESCRT II Complex
ERBB Signaling Pathway
Tissue Development
Ubiquitin-protein Transferase Activity
Regulation Of Cell Activation
Regulation Of Biological Quality
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
DNA Metabolic Process
DNA Repair
DNA Replication Initiation
Double-strand Break Repair Via Homologous Recombination
CMG Complex
MCM Complex
Recombinational Repair
DNA Replication
Double-strand Break Repair Via Break-induced Replication
Regulation Of DNA-templated DNA Replication Initiation
DNA Damage Response
Double-strand Break Repair
DNA Recombination
Chromosome, Telomeric Region
Regulation Of Cell Cycle Phase Transition
Single-stranded DNA Binding
Regulation Of DNA Replication
DNA Replication Origin Binding
Cellular Response To Stress
Single-stranded DNA Helicase Activity
Regulation Of Cell Cycle
Nucleic Acid Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Macromolecule Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Mitotic DNA Replication Initiation
Regulation Of Cell Cycle Process
Response To Stress
Negative Regulation Of Cell Cycle Phase Transition
Helicase Activity
Regulation Of Chromosome Segregation
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle Process
Mitotic G2/M Transition Checkpoint
Nucleoplasm
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Meiotic Cell Cycle
3'-5' DNA Helicase Activity
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Mitotic DNA Integrity Checkpoint Signaling
Negative Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Cell Cycle
Regulation Of Exit From Mitosis
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Protein Phosphorylation
Negative Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Phosphorylation
Regulation Of DNA Damage Checkpoint
Nucleolus
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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