DGCR6 and DNPEP

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		DGCR6	DNPEP
Description		DiGeorge syndrome critical region gene 6	aspartyl aminopeptidase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Extracellular Matrix	Nucleus Cytoplasm Cytosol Blood Microparticle
	Molecular Function	Protein Binding	Aminopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Cell Adhesion Animal Organ Morphogenesis	Proteolysis Peptide Metabolic Process
Pathways
Drugs			Glutamic acid
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Metabolite levels ( 23823483) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)	Height ( 31562340) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Triglyceride levels in HIV infection ( 33109212) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		67 interacting genes: ADAMTSL4 AGTRAP AKAP8L APP ARNT2 C1orf94 C3orf62 CBLL1 CBY2 CCDC33 CEP126 CTBP1 DEUP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 ESS2 FBF1 FH FTCD GOLGA2 GSE1 HGS HOMEZ IHO1 IKZF3 INIP KLHL12 KRTAP12-2 LZTS2 MBIP MEIS2 MEOX2 MIA2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NLA NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPRY2 SS18L1 TCF12 TCF4 TFIP11 TLE5 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446	8 interacting genes: ADAMTSL4 AGT DGCR6 LNX1 MDFI MPP1 PAK5 SAT1
Entrez ID		8214	23549
HPRD ID		03177	09924
Ensembl ID		ENSG00000183628	ENSG00000123992
Uniprot IDs		Q14129 X5D7D2	B7Z7F0 E5RIA4 E7ETB3 Q9ULA0
PDB IDs			4DYO
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Neuron Differentiation PTB Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Macromolecule Metabolic Process Nuclear Pore Central Transport Channel Regulation Of Transcription By RNA Polymerase II Microtubule Spindle Pole Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Thioesterase Binding Positive Regulation Of Metabolic Process DNA Binding Regulation Of Neuron Differentiation Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Ras Protein Signal Transduction Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Angiotensin-activated Signaling Pathway Extracellular Matrix Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Membrane Hyperpolarization Response To Muscle Activity Involved In Regulation Of Muscle Adaptation G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Renal Output By Angiotensin Type 2 Angiotensin Receptor Binding Diamine N-acetyltransferase Activity Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Pigment Cell Development
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