DGCR6 and MIA2

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		DGCR6	MIA2
Description		DiGeorge syndrome critical region gene 6	MIA SH3 domain ER export factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Extracellular Matrix	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding	Protein Binding Enzyme Activator Activity Cargo Receptor Activity
	Biological Process	Cell Adhesion Animal Organ Morphogenesis	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Secretion Protein Exit From Endoplasmic Reticulum Vesicle Cargo Loading Lipoprotein Transport Protein Localization To Endoplasmic Reticulum Exit Site
Pathways			Cargo concentration in the ER
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Metabolite levels ( 23823483) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)
Interacting Genes		67 interacting genes: ADAMTSL4 AGTRAP AKAP8L APP ARNT2 C1orf94 C3orf62 CBLL1 CBY2 CCDC33 CEP126 CTBP1 DEUP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 ESS2 FBF1 FH FTCD GOLGA2 GSE1 HGS HOMEZ IHO1 IKZF3 INIP KLHL12 KRTAP12-2 LZTS2 MBIP MEIS2 MEOX2 MIA2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NLA NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPRY2 SS18L1 TCF12 TCF4 TFIP11 TLE5 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446	15 interacting genes: CCHCR1 CEP57 DGCR6 EMILIN1 GRB2 MAGEB18 PDCD6 PSMA3 RASAL2 RSPH1 SEC23A SEC24C SS18L1 TLE5 TTC23L
Entrez ID		8214	4253
HPRD ID		03177	03680
Ensembl ID		ENSG00000183628	ENSG00000150527
Uniprot IDs		Q14129 X5D7D2	Q4G155 Q59FD2 Q96PC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Neuron Differentiation PTB Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Macromolecule Metabolic Process Nuclear Pore Central Transport Channel Regulation Of Transcription By RNA Polymerase II Microtubule Spindle Pole Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Thioesterase Binding Positive Regulation Of Metabolic Process DNA Binding Regulation Of Neuron Differentiation Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Ras Protein Signal Transduction Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	COPII Vesicle Coat Endoplasmic Reticulum Exit Site ER To Golgi Transport Vesicle Membrane Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Cargo Loading Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Developmental Process
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