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CDK5 and PSEN1
Number of citations of the paper that reports this interaction (PubMedID
21163940
)
58
Data Source:
BioGRID
(two hybrid)
HPRD
(in vitro, in vivo)
CDK5
PSEN1
Description
cyclin dependent kinase 5
presenilin 1
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Lamellipodium
Cell Junction
Filopodium
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Cell Projection
Neuron Projection
Neuronal Cell Body
Perikaryon
Synapse
Presynapse
Golgi Membrane
Kinetochore
Nucleus
Nuclear Outer Membrane
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosomal Membrane
Endosome
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Cell Cortex
Synaptic Vesicle
Cell Surface
Membrane
Aggresome
Cell Junction
Axon
Dendrite
Growth Cone
Cytoplasmic Vesicle
Neuromuscular Junction
Early Endosome Membrane
Nuclear Membrane
Protein-containing Complex
Ciliary Rootlet
Azurophil Granule Membrane
Sarcolemma
Presynaptic Membrane
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Synapse
Gamma-secretase Complex
Synaptic Membrane
Postsynapse
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
ErbB-2 Class Receptor Binding
Protein Binding
ATP Binding
Microtubule Binding
Kinase Activity
Transferase Activity
Signaling Receptor Inhibitor Activity
Acetylcholine Receptor Activator Activity
Ionotropic Glutamate Receptor Binding
ErbB-3 Class Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Hsp90 Protein Binding
Protein Serine Kinase Activity
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Calcium Channel Activity
Protein Binding
Beta-catenin Binding
Peptidase Activity
Hydrolase Activity
PDZ Domain Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Cadherin Binding
ATPase Binding
Growth Factor Receptor Binding
Biological Process
Microtubule Cytoskeleton Organization
Neuron Migration
Synaptic Transmission, Dopaminergic
Intracellular Protein Transport
Apoptotic Process
Cell-matrix Adhesion
Chemical Synaptic Transmission
Nervous System Development
Axonogenesis
Synapse Assembly
Skeletal Muscle Tissue Development
Motor Neuron Axon Guidance
Associative Learning
Visual Learning
Schwann Cell Development
Synaptic Vesicle Exocytosis
Regulation Of Macroautophagy
Cell Migration
Sensory Perception Of Pain
Telencephalon Development
Cerebellum Development
Cerebellar Cortex Development
Cerebellar Cortex Formation
Hippocampus Development
Layer Formation In Cerebral Cortex
Central Nervous System Neuron Development
Cerebral Cortex Development
Corpus Callosum Development
Actin Cytoskeleton Organization
Neuron Differentiation
Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Forebrain Development
Neuron Projection Development
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Synaptic Plasticity
Receptor Catabolic Process
Synaptic Transmission, Glutamatergic
Protein Localization To Synapse
Response To Cocaine
Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Proteolysis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Calcium Ion-dependent Exocytosis
Negative Regulation Of Protein Export From Nucleus
Behavioral Response To Cocaine
Regulation Of Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Transport
Rhythmic Process
Axon Extension
Oligodendrocyte Differentiation
Dendrite Morphogenesis
Cell Division
Neuron Apoptotic Process
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Postsynaptic Membrane Potential
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Morphogenesis
Calcium Ion Import
Positive Regulation Of Protein Targeting To Membrane
Positive Regulation Of Presynaptic Cytosolic Calcium Concentration
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
Regulation Of Synaptic Vesicle Recycling
Cellular Response To Amyloid-beta
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Development
Cell Fate Specification
Somitogenesis
Neuron Migration
Positive Regulation Of Receptor Recycling
Heart Looping
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Hematopoietic Progenitor Cell Differentiation
Astrocyte Activation Involved In Immune Response
T Cell Activation Involved In Immune Response
Myeloid Leukocyte Differentiation
Neural Retina Development
Protein Glycosylation
Proteolysis
Membrane Protein Ectodomain Proteolysis
Mitochondrial Transport
Intracellular Calcium Ion Homeostasis
Autophagy
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Cell Adhesion
Notch Signaling Pathway
Notch Receptor Processing
Brain Development
Heart Development
Learning Or Memory
Memory
Post-embryonic Development
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Neuron Projection Development
Protein Transport
Choline Transport
Synaptic Vesicle Targeting
Protein Processing
Cerebellum Development
Cerebral Cortex Cell Migration
Cajal-Retzius Cell Differentiation
Dorsal/ventral Neural Tube Patterning
Cerebral Cortex Development
Neurogenesis
Neuron Differentiation
Embryonic Limb Morphogenesis
Forebrain Development
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Tumor Necrosis Factor Production
Amyloid-beta Formation
Segmentation
Intracellular Signal Transduction
Locomotion
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Skin Morphogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Astrocyte Activation
Regulation Of Synaptic Plasticity
Thymus Development
Neuron Development
Skeletal System Morphogenesis
Brain Morphogenesis
Amyloid-beta Metabolic Process
Epithelial Cell Proliferation
Negative Regulation Of Axonogenesis
Synapse Organization
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Sequestering Of Calcium Ion
Neuron Apoptotic Process
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Protein Maturation
Regulation Of Synaptic Transmission, Glutamatergic
Calcium Ion Homeostasis
Regulation Of Resting Membrane Potential
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Dendritic Spine Development
Neuron Cellular Homeostasis
Calcium Ion Transmembrane Transport
Apoptotic Signaling Pathway
Cell-cell Adhesion
Regulation Of Synaptic Vesicle Cycle
L-glutamate Import Across Plasma Membrane
Regulation Of Postsynapse Organization
Protein Catabolic Process At Postsynapse
Cellular Response To Amyloid-beta
Negative Regulation Of Core Promoter Binding
Positive Regulation Of Amyloid Fibril Formation
Neuron Projection Maintenance
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
DARPP-32 events
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
NPAS4 regulates expression of target genes
Factors involved in megakaryocyte development and platelet production
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
TGFBR3 PTM regulation
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Trilaciclib
Diseases
Alzheimer's disease (AD)
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Acne inversa; Hidradenitis supprativa
GWAS
Age at first sexual intercourse (
34211149
)
Eyebrow thickness (
26926045
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Apolipoprotein B levels (
32203549
)
Glycated hemoglobin levels (
34059833
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
78 interacting genes:
AATK
ABL1
ACTN1
ALAS1
AMPH
APP
BAG6
CABLES1
CABLES2
CCND2
CCND3
CCNG1
CDC25A
CDC25B
CDC25C
CDC37
CDK16
CDK5R1
CDK5R2
CDK5RAP1
CDK5RAP2
CDKN1B
CHN1
CSNK1D
DAB1
DCX
DNM1
ERBB3
EZR
FSD1
FYN
FZR1
GAK
GRIN2A
GSK3B
H1-0
H1-1
H1-5
HTRA2
KIF26B
LMTK2
MAP2K1
MAPK10
MAPT
MAST1
MBP
MEF2A
MEOX2
MIR9-1HG
NDEL1
NEDD4
NEDD4L
NES
PAK1
PCNA
PIKFYVE
PIP5K1C
PPARG
PPP1R1B
PPP1R2
PSEN1
PTPN2
PURA
RB1
RNF32
RPL34
SET
SPDYA
SRC
STX1A
STXBP1
SYN1
SYNJ1
TLN1
TP53
TRIM59
WASF1
YBX3
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
Entrez ID
1020
5663
HPRD ID
00449
00087
Ensembl ID
ENSG00000164885
ENSG00000080815
Uniprot IDs
A0A090N7W4
A0A0S2Z355
Q00535
A0A024R6A3
A0A0S2Z4D2
P49768
PDB IDs
1H4L
1UNG
1UNH
1UNL
3O0G
4AU8
7VDP
7VDQ
7VDR
7VDS
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
6LQG
6LR4
7C9I
7D8X
7Y5T
8IM7
8K8E
8KCO
8KCP
8KCS
8KCT
8KCU
8OQY
8OQZ
8X52
8X53
8X54
Enriched GO Terms of Interacting Partners
?
Protein Kinase Binding
Cytosol
Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Developmental Process
Regulation Of Protein Modification Process
Intracellular Signal Transduction
Mitotic Cell Cycle Phase Transition
Regulation Of Cellular Component Organization
Regulation Of Neuron Apoptotic Process
Cell Cycle Phase Transition
Regulation Of Protein Serine/threonine Kinase Activity
Organelle Organization
Perinuclear Region Of Cytoplasm
Regulation Of Protein Kinase Activity
Cytoplasm
Cyclin-dependent Protein Kinase Holoenzyme Complex
Neuron Apoptotic Process
Regulation Of Organelle Organization
Regulation Of Kinase Activity
Kinase Activity
Cell Projection Organization
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Phosphorus Metabolic Process
Protein Kinase Activity
Regulation Of Phosphorylation
Regulation Of Cell Projection Organization
Regulation Of Neuron Projection Development
Cellular Developmental Process
Regulation Of Apoptotic Process
Endocytosis
Layer Formation In Cerebral Cortex
Regulation Of Protein Phosphorylation
Organelle Localization
Positive Regulation Of Cellular Component Organization
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Protein Catabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Apoptotic Process
Cellular Response To Oxygen-containing Compound
Regulation Of Mitotic Cell Cycle
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Organelle Organization
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Communication
Regulation Of Programmed Cell Death
Regulation Of Signaling
Regulation Of Apoptotic Process
Plasma Membrane
Positive Regulation Of Neuron Apoptotic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apoptotic Process
Regulation Of Protein Localization
Regulation Of Cell Development
Neuron Projection Development
Cytoplasm
Regulation Of Cell Differentiation
Programmed Cell Death
Regulation Of Developmental Process
Cell Death
Negative Regulation Of Developmental Process
Regulation Of Transport
Protein Processing
Cellular Response To Oxygen-containing Compound
Notch Signaling Pathway
Cytosol
Amyloid-beta Formation
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Signal Transduction
Regulation Of Biological Quality
Amyloid Precursor Protein Metabolic Process
Apoptotic Signaling Pathway
Negative Regulation Of Cell Development
Cellular Response To Indole-3-methanol
Cell Junction Organization
Regulation Of Establishment Of Protein Localization
Response To Indole-3-methanol
Cellular Localization
Modulation Of Chemical Synaptic Transmission
Cell-cell Junction
Regulation Of Synaptic Plasticity
Positive Regulation Of Proteolysis
Regulation Of Autophagy
Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Localization
Regulation Of Intracellular Signal Transduction
Protein Maturation
Regulation Of Developmental Growth
Amyloid Precursor Protein Catabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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