CDK5 and DCX

Number of citations of the paper that reports this interaction (PMID 15345747)
72

Data Source:
HPRD (in vitro)

		CDK5	DCX
Gene Name		cyclin-dependent kinase 5	doublecortin
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Perikaryon Postsynaptic Membrane	Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Neuron Projection
	Molecular Function	P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Cytoskeletal Protein Binding Kinase Activity Acetylcholine Receptor Activator Activity ErbB-3 Class Receptor Binding Ephrin Receptor Binding Tau-protein Kinase Activity	Protein Binding Microtubule Binding Protein Kinase Binding
	Biological Process	Neuron Migration Synaptic Transmission, Dopaminergic Intracellular Protein Transport Nucleocytoplasmic Transport Cell Cycle Cell-matrix Adhesion Synaptic Transmission Axon Guidance Synapse Assembly Skeletal Muscle Tissue Development Blood Coagulation Motor Neuron Axon Guidance Cell Proliferation Visual Learning Embryo Development Schwann Cell Development Synaptic Vesicle Exocytosis Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Corpus Callosum Development Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Cortical Actin Cytoskeleton Organization Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Positive Regulation Of Protein Binding Receptor Catabolic Process Serine Phosphorylation Of STAT3 Protein Synaptic Transmission, Glutamatergic Protein Localization To Synapse Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Regulated Secretory Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Autophosphorylation Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Neuron Death Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Receptor Activity	Neuron Migration Nervous System Development Axon Guidance Central Nervous System Development Brain Development Central Nervous System Projection Neuron Axonogenesis Intracellular Signal Transduction Axon Extension Dendrite Morphogenesis
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions Opioid Signalling DARPP-32 events CRMPs in Sema3A signaling Factors involved in megakaryocyte development and platelet production	Axon guidance Neurofascin interactions L1CAM interactions
Drugs		Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
Protein-Protein Interactions		68 interactors: ABL1 ACTN1 ALAS1 AMPH APP BAG6 BRCA1 C1orf61 CABLES1 CABLES2 CCND2 CCNG1 CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN GAK GRIN2A GSK3B H1F0 HIST1H1B HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A NDEL1 NEDD4 NEDD4L NES PAK1 PARK2 PCNA PIP5K1C PPARG PPP1R1B PPP1R2 PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 WASF1	29 interactors: ACD AP1M1 AP2M1 APP CALCOCO2 CDK5 FBXO25 GOLGA2 IKZF1 KIFC3 KRT40 KRTAP10-8 MEOX1 MID2 NFASC PAFAH1B1 POT1 PPP1CA PPP1R9B RINT1 SPAG5 SPP1 TERF1 TINF2 TRIM23 TRIM27 TRIM39 USP9X ZBTB5
Entrez ID		1020	1641
HPRD ID		00449	02127
Ensembl ID			ENSG00000077279
Uniprot IDs		Q00535	A8K340 B4DM53 O43602
PDB IDs		1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8	1MJD 2BQQ 2XRP 4ATU
Enriched GO Terms of Interacting Partners?		Nervous System Development Neurogenesis Regulation Of Cellular Component Organization Generation Of Neurons Regulation Of Protein Metabolic Process System Development Neuron Development Neuron Projection Development Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Differentiation Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cell Differentiation Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Developmental Process Brain Development Positive Regulation Of Cellular Protein Metabolic Process Axon Development Head Development Cellular Localization Regulation Of Organelle Organization Regulation Of Phosphorylation Cell Projection Morphogenesis Regulation Of Signaling Cell Development Central Nervous System Development Cell Part Morphogenesis Organelle Organization Locomotion Axon Guidance Cell Morphogenesis Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Cell Cycle Organelle Localization Regulation Of Neuron Death Regulation Of Cellular Localization Signaling Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Cell Cycle Negative Regulation Of Chromosome Organization Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process Regulation Of Organelle Organization Cell Division Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Biosynthetic Process Organelle Organization Regulation Of DNA Replication Regulation Of Developmental Growth Protein Localization To Chromosome, Telomeric Region Telomere Capping Regulation Of DNA Biosynthetic Process Movement Of Cell Or Subcellular Component Axonogenesis Cellular Component Assembly Protein Localization Positive Regulation Of Telomerase Activity Neuron Projection Development Cellular Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Regulation Of Growth Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Negative Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Neuron Development Immune System Process Positive Regulation Of Telomere Maintenance Hippocampus Development Positive Regulation Of Organelle Organization Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Cell Morphogenesis Involved In Differentiation Forebrain Development Developmental Cell Growth Negative Regulation Of Viral Release From Host Cell Neuron Differentiation
Tagcloud ?		accelerates antisense axonal besides cerebellar collectively cones constituents cytoskeleton designated elongation epitope extension isoform laminin linker machinery macroneurons map1b oligonucleotide p35 p39 proline redistribution reduces selectively stimulates subcellular subcortical	17p13 classical deletions disrupt epilepsy frontal gradient lis lis1 lissencephaly malformation mutations occipital overlapping parietal proline q23 repeats retardation sequencing sexes southern splice sporadic though truncation wd40 xlis xq22
Tagcloud (Difference) ?		accelerates antisense axonal besides cerebellar collectively cones constituents cytoskeleton designated elongation epitope extension isoform laminin linker machinery macroneurons map1b oligonucleotide p35 p39 redistribution reduces selectively stimulates subcellular subcortical	17p13 classical deletions disrupt epilepsy frontal gradient lis lis1 lissencephaly malformation mutations occipital overlapping parietal q23 repeats retardation sequencing sexes southern splice sporadic though truncation wd40 xlis xq22
Tagcloud (Intersection) ?		proline