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CDK5 and RPL34
Number of citations of the paper that reports this interaction (PubMedID
10049762
)
0
Data Source:
BioGRID
(pull down)
CDK5
RPL34
Description
cyclin dependent kinase 5
ribosomal protein L34
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Lamellipodium
Cell Junction
Filopodium
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Cell Projection
Neuron Projection
Neuronal Cell Body
Perikaryon
Synapse
Presynapse
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Ribosome
Cytosolic Large Ribosomal Subunit
Cytosolic Ribosome
Synapse
Extracellular Exosome
Ribonucleoprotein Complex
Molecular Function
Nucleotide Binding
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
ErbB-2 Class Receptor Binding
Protein Binding
ATP Binding
Microtubule Binding
Kinase Activity
Transferase Activity
Signaling Receptor Inhibitor Activity
Acetylcholine Receptor Activator Activity
Ionotropic Glutamate Receptor Binding
ErbB-3 Class Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Hsp90 Protein Binding
Protein Serine Kinase Activity
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
Cadherin Binding
Biological Process
Microtubule Cytoskeleton Organization
Neuron Migration
Synaptic Transmission, Dopaminergic
Intracellular Protein Transport
Apoptotic Process
Cell-matrix Adhesion
Chemical Synaptic Transmission
Nervous System Development
Axonogenesis
Synapse Assembly
Skeletal Muscle Tissue Development
Motor Neuron Axon Guidance
Associative Learning
Visual Learning
Schwann Cell Development
Synaptic Vesicle Exocytosis
Regulation Of Macroautophagy
Cell Migration
Sensory Perception Of Pain
Telencephalon Development
Cerebellum Development
Cerebellar Cortex Development
Cerebellar Cortex Formation
Hippocampus Development
Layer Formation In Cerebral Cortex
Central Nervous System Neuron Development
Cerebral Cortex Development
Corpus Callosum Development
Actin Cytoskeleton Organization
Neuron Differentiation
Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Forebrain Development
Neuron Projection Development
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Synaptic Plasticity
Receptor Catabolic Process
Synaptic Transmission, Glutamatergic
Protein Localization To Synapse
Response To Cocaine
Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Proteolysis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Calcium Ion-dependent Exocytosis
Negative Regulation Of Protein Export From Nucleus
Behavioral Response To Cocaine
Regulation Of Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Transport
Rhythmic Process
Axon Extension
Oligodendrocyte Differentiation
Dendrite Morphogenesis
Cell Division
Neuron Apoptotic Process
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Postsynaptic Membrane Potential
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Morphogenesis
Calcium Ion Import
Positive Regulation Of Protein Targeting To Membrane
Positive Regulation Of Presynaptic Cytosolic Calcium Concentration
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
Regulation Of Synaptic Vesicle Recycling
Cellular Response To Amyloid-beta
Cytoplasmic Translation
Translation
Pathways
DARPP-32 events
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
NPAS4 regulates expression of target genes
Factors involved in megakaryocyte development and platelet production
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Trilaciclib
Diseases
GWAS
Age at first sexual intercourse (
34211149
)
Eyebrow thickness (
26926045
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Apolipoprotein A1 levels (
32203549
)
Blond vs. brown/black hair color (
30531825
)
Height (
25282103
)
Interacting Genes
78 interacting genes:
AATK
ABL1
ACTN1
ALAS1
AMPH
APP
BAG6
CABLES1
CABLES2
CCND2
CCND3
CCNG1
CDC25A
CDC25B
CDC25C
CDC37
CDK16
CDK5R1
CDK5R2
CDK5RAP1
CDK5RAP2
CDKN1B
CHN1
CSNK1D
DAB1
DCX
DNM1
ERBB3
EZR
FSD1
FYN
FZR1
GAK
GRIN2A
GSK3B
H1-0
H1-1
H1-5
HTRA2
KIF26B
LMTK2
MAP2K1
MAPK10
MAPT
MAST1
MBP
MEF2A
MEOX2
MIR9-1HG
NDEL1
NEDD4
NEDD4L
NES
PAK1
PCNA
PIKFYVE
PIP5K1C
PPARG
PPP1R1B
PPP1R2
PSEN1
PTPN2
PURA
RB1
RNF32
RPL34
SET
SPDYA
SRC
STX1A
STXBP1
SYN1
SYNJ1
TLN1
TP53
TRIM59
WASF1
YBX3
10 interacting genes:
APP
CDK4
CDK5
DAPK3
DDX21
DNAJC8
FNDC3B
MAX
PTEN
SRPK2
Entrez ID
1020
6164
HPRD ID
00449
17996
Ensembl ID
ENSG00000164885
ENSG00000109475
Uniprot IDs
A0A090N7W4
A0A0S2Z355
Q00535
P49207
PDB IDs
1H4L
1UNG
1UNH
1UNL
3O0G
4AU8
7VDP
7VDQ
7VDR
7VDS
4UG0
4V6X
5AJ0
5LKS
5T2C
6IP5
6IP6
6IP8
6LQM
6LSR
6LSS
6LU8
6MTD
6MTE
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6W6L
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
7BHP
7F5S
7OW7
7XNX
7XNY
8A3D
8FKY
8FKZ
8FL2
8FL3
8FL4
8FL6
8FL7
8FL9
8FLA
8FLB
8FLC
8FLD
8FLE
8FLF
8G5Y
8G5Z
8G60
8G61
8G6J
8GLP
8IDT
8IDY
8IE3
8IFD
8IFE
8INE
8INF
8INK
8IPD
8IPX
8IPY
8IR1
8IR3
8JDJ
8JDK
8JDL
8JDM
8K2C
8OHD
8OJ0
8OJ5
8OJ8
8QFD
8QOI
8QYX
8RL2
8UKB
8XSX
8XSY
8XSZ
8Y0W
8Y0X
8YOO
8YOP
9C3H
9G8M
9GMO
Enriched GO Terms of Interacting Partners
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Protein Kinase Binding
Cytosol
Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Developmental Process
Regulation Of Protein Modification Process
Intracellular Signal Transduction
Mitotic Cell Cycle Phase Transition
Regulation Of Cellular Component Organization
Regulation Of Neuron Apoptotic Process
Cell Cycle Phase Transition
Regulation Of Protein Serine/threonine Kinase Activity
Organelle Organization
Perinuclear Region Of Cytoplasm
Regulation Of Protein Kinase Activity
Cytoplasm
Cyclin-dependent Protein Kinase Holoenzyme Complex
Neuron Apoptotic Process
Regulation Of Organelle Organization
Regulation Of Kinase Activity
Kinase Activity
Cell Projection Organization
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Phosphorus Metabolic Process
Protein Kinase Activity
Regulation Of Phosphorylation
Regulation Of Cell Projection Organization
Regulation Of Neuron Projection Development
Cellular Developmental Process
Regulation Of Apoptotic Process
Endocytosis
Layer Formation In Cerebral Cortex
Regulation Of Protein Phosphorylation
Organelle Localization
Positive Regulation Of Cellular Component Organization
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Protein Catabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Apoptotic Process
Cellular Response To Oxygen-containing Compound
Regulation Of Mitotic Cell Cycle
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Organelle Organization
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Negative Regulation Of Programmed Cell Death
Acetylcholine Receptor Activator Activity
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Cell Cycle
R-loop Processing
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of RNA Metabolic Process
Adult Behavior
Axonogenesis
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Excitatory Postsynaptic Potential
Regulation Of Mitotic Cell Cycle
Reproductive Behavior
Protein Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Amyloid-beta Complex
Regulation Of Cell Junction Assembly
Cell Projection Morphogenesis
Presynapse
Growth Cone Lamellipodium
Neuron Projection Organization
Regulation Of Neuron Apoptotic Process
Visual Behavior
Regulation Of Response To Calcium Ion
Regulation Of DNA-templated Transcription
Learning Or Memory
Amylin Binding
Neuron Projection Morphogenesis
Regulation Of RNA Biosynthetic Process
Response To Amyloid-beta
Positive Regulation Of Toll Signaling Pathway
Visual Learning
Cellular Response To Amyloid-beta
Modulation Of Excitatory Postsynaptic Potential
Synapse Organization
Nucleoplasm
Regulation Of Cell Cycle Process
Kinase Activity
Cyclin-dependent Protein Kinase Holoenzyme Complex
Negative Regulation Of Axonogenesis
Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
Positive Regulation Of Presynaptic Cytosolic Calcium Concentration
Regulation Of Myosin II Filament Organization
Negative Regulation Of Synaptic Vesicle Clustering
Cognition
Chemical Synaptic Transmission
Regulation Of Developmental Growth
Glial Cell Development
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Tagcloud (Intersection)
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