CDK5 and GAK

Number of citations of the paper that reports this interaction (PMID 9013862)
23

Data Source:
HPRD (in vivo, in vitro)

		CDK5	GAK
Gene Name		cyclin-dependent kinase 5	cyclin G associated kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Perikaryon Postsynaptic Membrane	Golgi Apparatus Focal Adhesion Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Cytoskeletal Protein Binding Kinase Activity Acetylcholine Receptor Activator Activity ErbB-3 Class Receptor Binding Ephrin Receptor Binding Tau-protein Kinase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Neuron Migration Synaptic Transmission, Dopaminergic Intracellular Protein Transport Nucleocytoplasmic Transport Cell Cycle Cell-matrix Adhesion Synaptic Transmission Axon Guidance Synapse Assembly Skeletal Muscle Tissue Development Blood Coagulation Motor Neuron Axon Guidance Cell Proliferation Visual Learning Embryo Development Schwann Cell Development Synaptic Vesicle Exocytosis Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Corpus Callosum Development Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Cortical Actin Cytoskeleton Organization Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Positive Regulation Of Protein Binding Receptor Catabolic Process Serine Phosphorylation Of STAT3 Protein Synaptic Transmission, Glutamatergic Protein Localization To Synapse Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Regulated Secretory Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Autophosphorylation Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Neuron Death Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Receptor Activity	Protein Phosphorylation Endoplasmic Reticulum Organization Golgi Organization Cell Cycle Epidermal Cell Differentiation Intrahepatic Bile Duct Development Cell Development Forebrain Morphogenesis Establishment Of Skin Barrier Clathrin Coat Disassembly Clathrin-mediated Endocytosis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions Opioid Signalling DARPP-32 events CRMPs in Sema3A signaling Factors involved in megakaryocyte development and platelet production	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs		Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS			Parkinson's disease ( 20711177 21292315 22438815 21738487) Parkinson's disease (familial) ( 18985386)
Protein-Protein Interactions		68 interactors: ABL1 ACTN1 ALAS1 AMPH APP BAG6 BRCA1 C1orf61 CABLES1 CABLES2 CCND2 CCNG1 CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN GAK GRIN2A GSK3B H1F0 HIST1H1B HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A NDEL1 NEDD4 NEDD4L NES PAK1 PARK2 PCNA PIP5K1C PPARG PPP1R1B PPP1R2 PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 WASF1	12 interactors: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 USO1
Entrez ID		1020	2580
HPRD ID		00449	03631
Ensembl ID			ENSG00000178950
Uniprot IDs		Q00535	E9PGR2 O14976
PDB IDs		1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8	3LL6
Enriched GO Terms of Interacting Partners?		Nervous System Development Neurogenesis Regulation Of Cellular Component Organization Generation Of Neurons Regulation Of Protein Metabolic Process System Development Neuron Development Neuron Projection Development Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Differentiation Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cell Differentiation Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Developmental Process Brain Development Positive Regulation Of Cellular Protein Metabolic Process Axon Development Head Development Cellular Localization Regulation Of Organelle Organization Regulation Of Phosphorylation Cell Projection Morphogenesis Regulation Of Signaling Cell Development Central Nervous System Development Cell Part Morphogenesis Organelle Organization Locomotion Axon Guidance Cell Morphogenesis Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Cell Cycle Organelle Localization Regulation Of Neuron Death Regulation Of Cellular Localization Signaling Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process	Intracellular Transport Establishment Of Localization In Cell Membrane Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Golgi Vesicle Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cellular Localization Regulation Of Defense Response To Virus By Virus Cell Growth Intracellular Protein Transport Regulation Of Protein Localization To Plasma Membrane Antigen Processing And Presentation Of Peptide Antigen Viral Process Transport Regulation Of Defense Response To Virus Antigen Processing And Presentation Developmental Process Cellular Protein Localization Negative Regulation Of Biosynthetic Process Regulation Of Protein Localization Protein Transport Axon Guidance Establishment Of Protein Localization Negative Regulation Of Protein Localization To Plasma Membrane Cell Differentiation Anatomical Structure Morphogenesis Growth Regulation Of Cellular Localization Regulation Of Cellular Response To Heat Axonogenesis Cell Development Axon Development Neuron Differentiation Protein Localization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Endocytosis Regulation Of Phosphorylation Cytoplasmic Transport Organelle Organization Immune System Process Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Neuron Apoptotic Process Brain Development
Tagcloud ?		accelerates antisense axonal besides cerebellar collectively cones constituents cytoskeleton designated elongation epitope extension isoform laminin linker machinery macroneurons map1b oligonucleotide p35 p39 proline redistribution reduces selectively stimulates subcellular subcortical	atp13a2 bst1 conclusively confirmation discuss dj1 eif4g1 familial fbxo7 gba gigyf2 growing hla hopefully htra2 loci lrrk2 mapt park16 parkin parkinson parkinsonism pink1 pla2g6 rare respective snca sporadic uchl1
Tagcloud (Difference) ?		accelerates antisense axonal besides cerebellar collectively cones constituents cytoskeleton designated elongation epitope extension isoform laminin linker machinery macroneurons map1b oligonucleotide p35 p39 proline redistribution reduces selectively stimulates subcellular subcortical	atp13a2 bst1 conclusively confirmation discuss dj1 eif4g1 familial fbxo7 gba gigyf2 growing hla hopefully htra2 loci lrrk2 mapt park16 parkin parkinson parkinsonism pink1 pla2g6 rare respective snca sporadic uchl1
Tagcloud (Intersection) ?